Pleural effusion is an interruption of a pleural cavity in the lung wall. The lung and chest wall reversal process leads to pleural fluid aggregation in the pleural space. The parietal lymphatic expansion occurs because of increased pleural fluid. This model has been developed to obtain new results of respiratory tract infections, and also investigated the reaction of injection on an unstable free and forced convection flow of visceral pleural fluid transports in two different vertical porous regions. Finally, the model gives an impact of COVID-19 in the human respiratory tract, as it helps to anticipate early summary of establishing current pandemic infection. Results are computed analytically and plotted graphically for various physical parameters. The main highlights of this paper are mixed convection has been investigated mathematically in porous media, the effect of temperature and velocity field of pleural fluid was analyzed based on human lung mechanism, heat exchange associates with mucus layer and pleural fluid layer corresponding to thermal radiation and heat absorption, contribution of injection parameter over the region’s mucus and pleural phase, it has shown high sensitivity flow in diagnosis of COVID-19 due to pleural effusion.