A large anisotropic plasticity of <scp>L</scp>-leucinium hydrogen maleate preserved at cryogenic temperatures

Arkhipov, Sergey G.; Losev, Evgeniy A.; Nguyen, T.T.; Rychkov, Denis A.; Boldyreva, Elena V.

doi:10.1107/s2052520619000441

Cited by 17 publications

(21 citation statements)

References 118 publications

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“…Understanding the relationship among mechanical properties, crystal structure and tableting behavior helps to show the essence of structure based assessment of mechanical properties of organic crystals. Arkhipov et al observed the plasticity of L-Leucinium hydrogen maleate crystals preserved at cryogenic temperatures [20]. The modifications and predictions of solubility of the organic crystals were reported by Zhang et al and Nicoud et al respectively [21,22].…”

Section: Introductionmentioning

confidence: 86%

Angle-Resolved Photoemission Study on the Band Structure of Organic Single Crystals

2020

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Angle-resolved photoemission spectroscopy (ARPES) is a vital technique, collecting data from both the energy and momentum of photoemitted electrons, and is indispensable for investigating the electronic band structure of solids. This article provides a review on ARPES studies of the electronic band structure of organic single crystals, including organic charge transfer conductors; organic semiconductors; and organo-metallic perovskites. In organic conductors and semiconductors, band dispersions are observed that are highly anisotropic. The Van der Waals crystal nature, the weak electron wavefunction overlap, as well as the strong electron-phonon coupling result in many organic crystals having indiscernible dispersion. In comparison, organo-metallic perovskite halides are characterized by strong s-p orbitals from the metal and halide at the top of the valence bands, with dispersions similar to those in inorganic materials.

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Section: Introductionmentioning

confidence: 86%

Angle-Resolved Photoemission Study on the Band Structure of Organic Single Crystals

2020

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“…Within this frame, multicomponent solids comprising salts and cocrystals have inspired great interest owing to their ability to enhance the physicochemical properties of APIs [4]. In addition, the classification of intermolecular interactions into supramolecular synthons has allowed for simplifying the extended scaffold of multicomponent solids into modular units, facilitating their study [5] and the better understanding of the relationship between structural packing and their effects on different physicochemical (melting point [6], solubility [7] or stability [8], among others [9][10][11][12][13][14]) and mechanical properties [15,16].…”

Section: Introductionmentioning

confidence: 99%

Cocrystals Based on 4,4’-bipyridine: Influence of Crystal Packing on Melting Point

et al. 2021

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The reactions of piperonylic acid (HPip) and cinnamic acid (HCinn) with 4,4’-bipyridine (4,4’-bipy) have been assayed using the same synthetic methodology, yielding two binary cocrystals with different acid:4,4’-bipy molar ratios, (HPip)(4,4’-bipy) (1) and (HCinn)2(4,4’-bipy) (2). The melting point (m.p.) of these cocrystals have been measured and a remarkable difference (ΔT ≈ 78 °C) between them was observed. Moreover, the two cocrystals have been characterized by powder X-ray diffraction (PXRD), elemental analysis (EA), FTIR-ATR, 1H NMR spectroscopies, and single-crystal X-ray diffraction. The study of their structural packings via Hirshfeld surface analysis and energy frameworks revealed the important contribution of the π···π and C-H···π interactions to the formation of different structural packing motifs, this being the main reason for the difference of m.p. between them. Moreover, it has been observed that 1 and 2 presented the same packing motifs as the crystal structure of their corresponding carboxylic acids, but 1 and 2 showed lower m.p. than those of the carboxylic acids, which could be related to the lower strength of the acid-pyridine heterosynthons respect to the acid-acid homosynthons in the crystal structures.

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“…mechanical) properties, especially labile pharmaceutical materials and dynamic crystals aimed at various innovative technological applications. Although previous work has already addressed mechanical anisotropy in organic crystals with respect to thermal expansion and Hbonding patterns, 35,38,39,[60][61][62][63] our discussion shows that molecular vibrations and defects may add to the scope of future investigations.…”

Section: Discussionmentioning

confidence: 87%

Understanding stress-induced disorder and breakage in organic crystals: beyond crystal structure anisotropy

et al. 2021

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A large anisotropic plasticity of L-leucinium hydrogen maleate preserved at cryogenic temperatures

Cited by 17 publications

References 118 publications

Angle-Resolved Photoemission Study on the Band Structure of Organic Single Crystals

Angle-Resolved Photoemission Study on the Band Structure of Organic Single Crystals

Cocrystals Based on 4,4’-bipyridine: Influence of Crystal Packing on Melting Point

Understanding stress-induced disorder and breakage in organic crystals: beyond crystal structure anisotropy

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