Starting from 1960s, a great number of missions and experiments have been performed for the study of the high-energy sky. This review gives a wide vision of the most important space missions and balloon experiments that have operated in the 10-600 keV band, a crucial window for the study of the most energetic and violent phenomena in the Universe. Thus it is important to take the stock of the achievements to better establish what we have still to do with future missions in order to progress in this field, to establish which are the technologies required to solve the still open issues and to extend our knowledge of the Universe.