A Large Case‐Control Study of Cervical Cancer Risk Associated with Human Papillomavirus Infection in Japan, by Nucleotide Sequencing–Based Genotyping

Asato, Tsuyoshi; Maehama, Toshiyuki; Nagai, Yutaka; Kanazawa, Kazuki; Uezato, Hiroshi; Kariya, Ken-ichi

doi:10.1086/382896

Cited by 76 publications

(76 citation statements)

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“…Other reports using HPV genotyping tests also showed that HPV 52 was a more common genotype among Japanese individuals who had either normal cytology or cervical neoplastic lesions compared with individuals in other countries. 10,19,20 In Japan, a commercial cervical cancer vaccine finally became available after December 2009. This study has some limitations because we obtained data from pregnant women; however, our data from pre-vaccination women on the distribution of genital HPV infections in the region where HPV 52 is more prevalent are important for the understanding of the cross-reactivity of a bivalent HPV vaccine.…”

Section: Discussionmentioning

confidence: 99%

“…For consistency with previous studies, we considered 16 HPV genotypes (16, 18, 31, 33, 35, 45, 51, 52, 53, 56, 58, 59, 66, 68, 73 and 82) as high-risk genotypes that are related to cervical cancer. [8][9][10] RESULTS A total of 151 women were enrolled in the study. In all, 79 women were in the first trimester of their pregnancy, 18 were in the second trimester, 51 were in the third trimester and 3 were postpartum.…”

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Epidemiology of human papillomavirus genotypes in pregnant Japanese women

et al. 2011

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To investigate the pre-vaccination epidemiology of genital human papillomavirus (HPV) infections and genotypes in pregnant Japanese women, we performed Pap smear tests and HPV genotype testing in patients attending Nagasaki University Hospital and collaborating hospitals from August 2007 to July 2010. Serial uterine cervical specimens were obtained from 151 pregnant women. The HPV test was positive on the first visit in 54 women (35.8%; 54/151, average age 30). A total of 49 women (32.5%; 49/151) were infected by at least one high-risk HPV and 5 women were infected by only low-risk HPV. The three most prevalent high-risk HPV genotypes were HPV 52 (31.5%; 17/54), HPV 16 (29.6%; 16/51) and HPV 31 (13.0%; 7/51). The HPV infection pattern (negative, single infection and multiple infection) differed significantly according to the pregnancy trimester (v 2 -test; Po0.01(Pearson)). Among HPV-infected pregnant Japanese women, HPV52 was the most common genotype. The second most common genotype was HPV16, and these two genotypes accounted for B60% of HPV-positive pregnant women. Infection with multiple HPV genotypes was observed more frequently in the first trimester of pregnancy and the pattern of infection changed significantly depending on pregnancy stage. (2011) 56, 313-315; doi:10.1038/jhg.2011 published online 10 February 2011 Keywords: epidemiology; genotype; HPV; infection; pregnancy; uterine cervical neoplasia INTRODUCTION Persistent infections with human papillomavirus (HPV) are recognized as a major cause of cervical cancer. Genital infections with HPV are very common, and these infections are transmitted by sexual contact. 1 In most cases, HPV infections disappear naturally in a relatively short time period and carry only a small risk of disease development; 2-4 however, some investigators believe that pregnancy affects the host immune system; for example, pregnancy is believed to reduce seroreactivity against HPV infection. 5 Estrogen and progesterone have been shown to activate the upstream regulatory region of HPV18 (see ref. 6). Thereby altering HPV clearance rates compared with non-pregnant women. During persistent infection, important factors of disease susceptibility include HPV genotypes and viral characteristics, such as the distribution of each type in the population and the evasive ability against the host's immune system. It is not clear how persistent infection relates to the host, such as how the host immune system reacts against a specific HPV genotype and how sexual behavior in pregnant women affects infection rates. In particular, there are very few data detailing HPV genotype prevalence in pregnant Japanese women. To determine the distribution of HPV infections in pregnant Japanese women, we performed HPV genotype testing. Journal of Human Genetics MATERIALS AND METHODS Study population and sample collectionCytology and HPV DNA test samples were collected by six hospitals that collaborated with Nagasaki University Hospital from August 2007 to July 2010. All pregnant women whose first visit ...

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Section: Discussionmentioning

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Epidemiology of human papillomavirus genotypes in pregnant Japanese women

et al. 2011

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“…In contrast to the results for HPV16, HPV18 and HPV58, a significant protective effect of HLA-B15 was observed for HPV52-positive cases. HPV52 has also been found in a relatively higher frequency in a few Asian cities including Japan, 25 China 26 and Taiwan 27 where HLA-B15 is also a common allele. It would be worthwhile to examine whether similar protective effect exists in these populations.…”

Section: Discussionmentioning

confidence: 99%

HLA-B alleles, high-risk HPV infection and risk for cervical neoplasia in southern Chinese women

Chan

Cheung

et al. 2005

Int. J. Cancer

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A population-based study was conducted on 256 southern Chinese with cervical intraepithelial neoplasia grade III (CIN III) or invasive cervical cancer (ICC) and on 258 controls to examine the associations between HLA-B alleles, infection with high-risk human papillomaviruses (HPVs) and the development of cervical neoplasia. HLA-B15 was found to be protective for CIN III/ICC overall (p corrected 5 0.003), and for HPV52-positive CIN III/ICC (p corrected 5 0.003). A marginal protective effect of B15 was observed for HPV16-positive CIN III/ICC, but no significant associations were revealed for HPV18-or HPV58-positive cases. None of the HLA-B alleles were found to confer an increased risk for cervical neoplasia. HLA-B15 is common among Asian for whom HPV52, a worldwide uncommon HPV type, also exists in a relatively high prevalence. It would also be worthwhile to assess the association between HLA-B15, HPV52 and cervical cancer in other Asian populations. ' 2005 Wiley-Liss, Inc.Key words: HLA; Chinese; HPV; cervical cancer; host genetics Infection with high-risk human papillomaviruses (HPVs) is necessary for the development of cervical cancer.1 However, HPV infection alone is not sufficient and most HPV infections regress spontaneously. For cases that do progress to cancer, a long period of latency is usually required. It has become evident that a combination of environmental, viral and host factors interplay to influence the malignant progression.2 The human leukocyte antigen (HLA) system is involved in presenting foreign antigens to immune cells. This family of molecules is divided into 2 major classes. The class I molecules including A, B and C are expressed in most nucleated cells and are essential for targeting infected cells for killing by cytotoxic T-cells. HLA polymorphism results in variation of the peptide binding cleft that influences the immune response to pathogens. Certain HLA alleles have shown to be associated with an increased or decreased risk for cervical cancer among different ethnic populations. 4 Although cervical cancer remains an important cause of death in most parts of China, so far little is known on its association with HLA alleles. The objective of our study was to assess the association between HLA alleles and high-risk HPV infections on the risk of development of cervical neoplasia in southern Chinese. Our study focused on the HLA class I B alleles, as most previous studies have been on class II alleles. Material and methods Case subjectsA population-based study was performed to compare the frequency of HLA-B alleles between Hong Kong Chinese women with cervical neoplasia and controls. Women attending the Gynaecology Clinic at the Prince of Wales Hospital with biopsy-confirmed cervical intraepithelial neoplasia (CIN) III or invasive cervical carcinoma (ICC) were recruited. Peripheral blood samples and cervical scrape/biopsy samples were collected from participants with a written informed consent. Women with surnames that appeared to be non-Chinese were excluded from the study. The study...

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“…Nested PCR amplification of a conserved region of the HPV L1 gene DNA with the consensus MY09/MY11 and GP5 + /GP6 + primers (Table 1), followed by genotyping with direct DNA sequencing [22][23][24][25], was used for HPV DNA detection. For primary PCR amplification, all specimens were first subjected to PCR amplification with HPV consensus primers MY09/MY11.…”

Section: Hpv Detection and Typing By Sequencingmentioning

confidence: 99%

Human papillomavirus detection in Moroccan patients with bladder cancer

Berrada

Albouzidi

Ameur

et al. 2013

J Infect Dev Ctries

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Introduction: Human papillomavirus (HPV) is associated with more human cancers than any other virus. Many studies have investigated the association between bladder cancer and HPV but the results remain controversial. The aim of the present study is to evaluate whether HPV have an etiological role in bladder carcinogenesis among Moroccan patients. Methodology: Forty-eight fresh biopsies (43 bladder tumors and 5 non-tumor samples) were collected for this purpose. Nested PCR with the consensus MY09/MY11 and GP5

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A Large Case‐Control Study of Cervical Cancer Risk Associated with Human Papillomavirus Infection in Japan, by Nucleotide Sequencing–Based Genotyping

Cited by 76 publications

References 16 publications

Epidemiology of human papillomavirus genotypes in pregnant Japanese women

Epidemiology of human papillomavirus genotypes in pregnant Japanese women

HLA-B alleles, high-risk HPV infection and risk for cervical neoplasia in southern Chinese women

Human papillomavirus detection in Moroccan patients with bladder cancer

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