A large focus of naturally acquired Plasmodium knowlesi infections in human beings

Singh, Balbir; Sung, Lee Kim; Matusop, Asmad; Radhakrishnan, Anand; Shamsul, Sunita S. G.; Cox-Singh, Janet; Thomas, Alan W.; Conway, David J.

doi:10.1016/s0140-6736(04)15836-4

Cited by 963 publications

(1,146 citation statements)

References 22 publications

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“…Même si les infections sont souvent associées à une fièvre et à une anémie, Plasmodium ne semble pas provoquer de maladies graves en général (Wolfe et al 2002 ;Reid et al 2006 ;Pacheco et al 2012). Bien que le parasite du paludisme ne semble pas provoquer de maladie létale chez les grands singes, les plasmodies peuvent passer d'une espèce hôte à une autre (Singh et al 2004 ;Liu et al 2010) ; l'empiètement humain dans les zones de forêts facilite sans doute la permutation d'un hôte à l'autre des parasites du paludisme (Cox-Singh et Singh 2008). Les altérations de la densité animale, en particulier dans les centres de réhabilitation, peuvent aussi contribuer à l'échange de ces différentes plasmodies.…”

Section: Maladies Parasitairesunclassified

Lignes directrices pour de meilleures pratiques en matière de suivi de la santé et de contrôle des maladies des populations de grands singes

Gilardi¹,

Gillespie²,

Leendertz³

et al. 2016

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Section: Maladies Parasitairesunclassified

Lignes directrices pour de meilleures pratiques en matière de suivi de la santé et de contrôle des maladies des populations de grands singes

Gilardi¹,

Gillespie²,

Leendertz³

et al. 2016

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“…1,2 The disease is endemic to all continents apart from Antarctica, but is confined principally to tropical regions. 3,4 Of a world population of around 7.1 billion people, 5 3.4-3.7 billion are at risk of contracting malaria.…”

Section: Introductionmentioning

confidence: 99%

Advancement Towards an Approved Vaccine to Target Plasmodium Falciparum Malaria

Taylor‐Robinson

2014

IJI

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Abstract:Plasmodium falciparum causes the severest form of malaria which kills well over one million persons each year, chiefly children, and results in significant debilitation in hundreds of millions more. This disease has a dramatic socioeconomic impact in endemic countries and thus it is a recurring target for global health enterprises. Increased investment in existing control measures, including insecticide-impregnated bed nets, has been paired with revitalized efforts to develop an efficacious vaccine. Sequencing of the genome of P. falciparum has provided insights into the malaria parasite's complex lifecycle, which, combined with a deeper understanding of the human immune response to infection, has yielded many novel candidate vaccines during the past two decades. Most notable of these is RTS,S which has shown great promise over a long development process, becoming the first candidate vaccine against human malaria to advance to phase III clinical trials. Hence, there is optimism that in the near future RTS,S may become the first ever licensed vaccine against a parasitic disease in humans. However, this is qualified by the need for a better knowledge of its mechanism of protection and questions raised over its long-term therapeutic capacity. While the availability of RTS,S as a validated commercial product is not guaranteed, it is likely to contribute to the continuing campaign against malaria, if only as a forerunner to a fine-tuned second generation vaccine.

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“…Currently, artemisinin-based combination therapy (ACT) is recommended for the treatment of P. falciparum malaria (Singh et al, 2004;WHO, 2011). In the treatment, fast acting artemisinin based compounds are combined with a drug from a different class.…”

Section: Introductionmentioning

confidence: 99%

Comparative study of protective effect of separate administration of vitamin C and folic acid in act therapy induced hepatic injury

Bukunola¹,

Ogunlabi²,

Aramide³

et al. 2014

Sci. Res. Essays

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Artemisinin and its derivatives are among the most effective antimalarial drugs used today. This study compared the effects of pre-treatment with vitamin C and folic acid on the hepatotoxic effect of artemisinin combination. Thirty male wistar rats randomly assigned to six groups of five rats each were used in the study. Group A was the normal control; groups B, C, D, E and F were placed on therapeutic doses of leonart, leonart+vitamin C, leonart + folic acid, vitamin C and folic acid respectively. They were pretreated with the respective supplements for 28 days while administration of leonart was carried out for four days starting from the 24 th day of supplements administration. The rats were thereafter sacrificed by cervical dislocation after an overnight fasting. Serum prepared from the whole blood and homogenized liver were then used for analysis. The result indicates that leonart administration raised the level of malaondialdehyde, serum total, conjugated bilirubin and the activities of alanine transaminase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP). It however decreases the activities of liver catalase, superoxide dismutase (SOD) and glutathione (GSH) level. Combined administration of leonart with vitamin C restored these parameters to pretreatment levels. Neither separate nor combined administration of folic acid with leonart altered any of these parameters.

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A large focus of naturally acquired Plasmodium knowlesi infections in human beings

Cited by 963 publications

References 22 publications

Lignes directrices pour de meilleures pratiques en matière de suivi de la santé et de contrôle des maladies des populations de grands singes

Lignes directrices pour de meilleures pratiques en matière de suivi de la santé et de contrôle des maladies des populations de grands singes

Advancement Towards an Approved Vaccine to Target Plasmodium Falciparum Malaria

Comparative study of protective effect of separate administration of vitamin C and folic acid in act therapy induced hepatic injury

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