A large nationwide population-based case–control study of the association between intussusception and later celiac disease

Ludvigsson, Jonas F.; Nordenskjöld, Agneta; Murray, Joseph A.; Olén, Ola

doi:10.1186/1471-230x-13-89

Cited by 17 publications

(15 citation statements)

References 30 publications

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“…11 Despite previously reported intussusception associated with CD, Ludvigsson JF et al, found no such association, but a modest increased risk of intussusception after diagnosis of CD. 14 In one prospective study, where all 150 serology-positive and biopsy-proven CD children with a median age of 72 months were screened irrespective of symptoms, intussusception was present in 25% with 95% involving small bowel. All but one had asymptomatic intussusception.…”

Section: Discussionmentioning

confidence: 99%

Intussusception associated with celiac disease in a child: case report and review of literature

Kumar

Bansal²,

Parihar

2019

Int J Contemp Pediatr

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Intussusception and celiac disease both are common in children. Intussusception has been rarely associated with celiac disease in children, which mostly involved small bowel, are transient without classical symptoms, reduced spontaneously and rarely needs intervention. Authors are reporting a 2-year girl who presented initially as gastroenteritis and later on intestinal obstruction and on investigation revealed ileo-ileal intussusception which resolved spontaneously during laparotomy preparation. The patient had growth retardation and microcytic hypochromic anemia and on further evaluation diagnosed with celiac disease. This case report highlights the need of celiac testing in children with intussusception, and such intussusception resolved spontaneously with gluten free diet and rarely needs any active intervention, thus preventing from undue nonsurgical or surgical interventions for intussusception.

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Section: Discussionmentioning

confidence: 99%

Intussusception associated with celiac disease in a child: case report and review of literature

Kumar

Bansal²,

Parihar

2019

Int J Contemp Pediatr

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“…[1][2][3][4] It is the most common cause of intestinal obstruction at pediatric ages and needs prompt intervention, which may be surgical or nonsurgical.…”

Section: Discussionmentioning

confidence: 99%

“…3 Nonetheless, using a prospective cohort approach, a post-hoc analysis found that 12 out of 29,060 individuals with celiac disease were given a diagnosis of intussusception after the onset of celiac disease, with a modest but significant increase risk of intussusception after celiac disease had been diagnosed (odds ratio, OR = 1.95; 95% confidence interval, CI = 1.01-3.77; P = 0.046). In that study, patients with celiac disease without symptoms were not serially investigated with abdominal imaging, which may have reduced the absolute numbers of patients with subclinical intussusception who did not seek acute care and were unaccounted for.…”

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confidence: 99%

A rare association of intussusception and celiac disease in a child

2016

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CONTEXT: Intussusception is a common cause of acute intestinal obstruction in the pediatric population and it is normally idiopathic. Rare cases of chronic intussusception require investigation with greater attention. CASE REPORT: We present a clinical case of a three-year-old boy with aqueous diarrhea, abdominal distension, vomiting and weight loss over a two-month period. During the investigation, abdominal ultrasound showed imaging of intussusception. The intraoperative findings showed the intussusception had resolved spontaneously. In further investigation, it was found that the diarrhea was malabsorptive and, after the patient underwent upper gastrointestinal endoscopy, a diagnosis of celiac disease was made. After a gluten-free diet was introduced, the patient showed complete remission of symptoms and regained weight, and normal growth was reestablished. CONCLUSION: If the clinical presentation of intussusception is unusual, etiological investigation should be undertaken. In this case report, celiac disease was the underlying cause.RESUMO CONTEXTO: Intussuscepção é uma causa frequente de obstrução intestinal aguda em pacientes pediátricos, e geralmente é idiopática. Raros casos de intussuscepção crônica devem ser investigados com maior atenção. RELATO DE CASO: Apresentaremos um caso clínico de um menino de três anos com diarreia aquosa, distensão abdominal, vômito e perda de peso por dois meses, cuja investigação por ultrassonografia abdominal revelou imagem de intussuscepção. Os achados intraoperatórios mostraram que a intussuscepção havia se resolvido espontaneamente. Em investigação subsequente, foi identificado que a diarreia era malabsortiva e, após a realização de endoscopia digestiva alta, foi feito diagnóstico de doença celíaca. Foi iniciada dieta com restrição de glúten e o paciente teve remissão completa dos sintomas, recuperou peso e o crescimento foi restabelecido. CONCLUSÃO: Caso a apresentação clínica de intussuscepção não seja a habitual, deve-se prosseguir a investigação etiológica. No caso clínico apresentado, doença celíaca foi a causa subjacente.I MD, MSc. Attending Physician,

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“…Typical symptoms are abdominal pain, nausea, lethargy, vomiting and sometimes bleeding from the rectum ("red currant jelly") [8]. However, the most common presentation is the triad of abdominal mass, tenderness, and hemoglobin-positive stools.…”

Section: Discussionmentioning

confidence: 99%

Žarnų invaginacija – reta suaugusių žmonių žarnų nepraeinamumo priežastis

Poškus¹,

Grišin²

2015

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BackgroundIntestinal intussusception is a rare cause of abdominal pain in adults and stands for only 5% of all cases with acute abdominal pain. While the clinical signs of pediatric invagination are obvious, surgeons struggle with preoperative diagnosis of adult intestinal invagination because of non-specific symptoms, which can result in misleading diagnosis. Therefore, it is mandatory to evaluate the risk of bowel intussusception when there is lack of evidence to explain constipation symptoms in adults. MethodsThe correct diagnosis of bowel obstruction can lead to tumor detection, which causes 86% of small bowel intussusception in adults. Ultrasound and plain X-ray examination procedures are not effective to diagnose intestinal obstruction. CT is the "golden standard" diagnostic procedure; therefore, it is mandatory for doctors to correctly interpret the non-specific obstruction ("target" or "sausage shaped" thickened part of a bowel) signs. ResultsThe abdominal ultrasound showed minimal fluid in the right iliac fossa where appendectomy was performed a week ago. The plain X-ray examination of the abdomen did not show signs of small bowel obstruction. The CT scan performed later on showed ileocecal intussusception, dilated bowel loops and signs of regional lymphadenopathy, which was the main indication for immediate surgery. ConclusionIntestinal intussusception is a rare cause of adult recurrent abdominal pain, which can be misled by an insufficient diagnostic criteria. The CT imaging is the most precise diagnostic method in early pathology detection. Resection of involved bowel is recommended when treating these patients because, in most cases, intussusception is caused by a neoplasm of the bowel. Key words: intestinal intussusception, CT scan, X Ray, abdominal pain, neoplasm Klinikinė praktika 271Adult intussusception -a rare cause of intestinal obstruction in adults Įvadas Žarnų invaginacija -retai pasitaikanti pilvo skausmų priežastis, diagnozuojama tik 5 % suaugusiųjų, turinčių ūmaus pilvo sindromą. Ši patologija dažnesnė vaikams ir jiems yra lengvai diagnozuojama, tačiau suaugusiems pacientams ši žarnų nepraeinamumo priežastis yra sunkiai nustatoma. Žarnų obstrukcijos požymiai yra nespecifiniai, todėl kartais gydytojų diagnozė gali būti klaidinga. Dėl šių priežasčių yra būtina įtarti žarnų invaginacijos riziką visiems suaugusiems žmonėms, besiskundžiantiems grįžtamais pilvo skausmais be jokių gretutinių specifinių požymių išraiškos. Metodai Tikslus žarnų obstrukcijos diagnostikos algoritmo pasirinkimas yra svarbus veiksnys tikrajai ūmaus pilvo skausmų priežasčiai nustatyti. Dažniausiai diagnozuojama priežastis suaugusiems pacientams yra navikinis darinys, kuris lemia 86 % visų žarnų nepraeinamumo atvejų. Ultragarsiniai tyrimai bei rentgeno tyrimas yra nepakankamai specifiški šiai patologijai nustatyti. Kompiuterinė tomografija yra auksinis standartas retai žarnų nepraeinamumo priežasčiai nustatyti, todėl šiuo atveju yra būti-nas gydytojų budrumas analizuojant ir įvertinant nespecifinius žarnų invaginacijo...

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A large nationwide population-based case–control study of the association between intussusception and later celiac disease

Cited by 17 publications

References 30 publications

Intussusception associated with celiac disease in a child: case report and review of literature

Intussusception associated with celiac disease in a child: case report and review of literature

A rare association of intussusception and celiac disease in a child

Žarnų invaginacija – reta suaugusių žmonių žarnų nepraeinamumo priežastis

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