A large proportion of prediabetes and diabetes goes undiagnosed when only fasting plasma glucose and/or HbA1c are measured in overweight or obese patients

Cosson, E.; Hamo-Tchatchouang, E.; Banu, I.; Nguyen, Minh Tuan; Chiheb, S.; Ba, H.; Valensi, P.

doi:10.1016/j.diabet.2010.02.004

Cited by 35 publications

(19 citation statements)

References 23 publications

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“…Also, in overweight and obese subjects, measuring only fasting plasma glucose concentrations and HbA 1c ratio are inadequate means for prediabetes screening. 61 OGTT remains the gold standard for the direct evaluation of insulin secretion, and the indirect evaluation of the degree of insulin resistance.…”

Section: Screening For Prediabetesmentioning

confidence: 99%

Prediabetes and Adolescence—Trends, Causes, Effects, and Screening

Stefanaki¹

2016

US Endocrinology

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Intermediate hyperglycemia, or prediabetes, is increasing worldwide, affecting people of all ages, including adolescents. Hormonal, physiological, psychological, and lifestyle changes in adolescence have been associated with disruptions in glucose homeostasis, such as decreased insulin sensitivity, insulin resistance, or the combination of both. As a rule, glucose homeostasis is ameliorated, in normal subjects, when puberty is completed. However, in susceptible individuals, like obese adolescents, or adolescents with a strong genetic background, there is a progression to type 2 diabetes onset. Thus, susceptible adolescents should be screened for prediabetes, using fasting plasma glucose, and glycated hemoglobin (HbA 1c ), and oral glucose tolerance testing. Prediabetic adolescents should be counseled for a healthy lifestyle including healthy dietary habits, increased physical activity, and/or stress management. Other pathological conditions should be adequately treated. Early recognition of prediabetes in adolescence will prevent type 2 diabetes onset, decreasing the diabetes-associated health burden in adult life. This review aims to revise the associations and elucidate on the gaps between prediabetes and adolescence, via a comprehensive review of the current medical literature.

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Section: Screening For Prediabetesmentioning

confidence: 99%

Prediabetes and Adolescence—Trends, Causes, Effects, and Screening

Stefanaki¹

2016

US Endocrinology

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“…Although there is evidence that the use of HbA 1c to identify patients with prediabetes may lead to underdiagnosis of patients with prediabetes, [34][35][36] HbA 1c is the only measure of glucose metabolism available for all participants in the NHANES. Fasting plasma glucose and oral glucose tolerance testing are available only for subsets of respondents.…”

Section: -33mentioning

confidence: 99%

Prevalence of Prediabetes and Abdominal Obesity Among Healthy-Weight Adults: 18-Year Trend

Mainous

Tanner

et al. 2016

The Annals of Family Medicine

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PURPOSE Trends in sedentary lifestyle may have influenced adult body composition and metabolic health among individuals at presumably healthy weights. This study examines the nationally representative prevalence of prediabetes and abdominal obesity among healthy-weight adults in 1988 through 2012. METHODSWe analyzed the National Health and Nutrition Examination Survey (NHANES) III (1988III ( -1994 and NHANES for the years 1999 to 2012, focusing on adults aged 20 years and older who have a body mass index (BMI) of 18.5 to 24.99 and do not have diabetes, either diagnosed or undiagnosed. We defined prediabetes using glycated hemoglobin (HbA 1c ) level ranges from 5.7% to 6.4%, as specified by the American Diabetes Association. Abdominal obesity was measured by waist circumference and waist-to-height ratio. RESULTSThe prevalence of prediabetes among healthy-weight adults, aged 20 years and older and without diagnosed or undiagnosed diabetes, increased from 10.2% in 1988-1994 to 18.5% in 2012. Among individuals aged 45 years and older, the prevalence of prediabetes increased from 22.0% to 33.1%. The percentage of adults aged 20 years and older with an unhealthy waist circumference increased from 5.6% in 1988-1994 to 7.6% in 2012. The percentage of individuals with an unhealthy waist-to-height ratio increased from 27.2% in 1988-1994 to 33.7% in 2012. Adjusted models found that measures of abdominal obesity were not independent predictors of prediabetes among adults with a healthy BMI.CONCLUSIONS Among individuals within a healthy BMI range, the prevalence of prediabetes and abdominal obesity has substantially increased. Abdominal obesity does not appear to be the primary cause of the increase.

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“…The sensitivity of HbA 1c testing was assessed in a Paris study by Cosson et al (2010). 88 In a group mainly composed of obese women, they compared FPG and HbA 1c with the 2-hour OGTT.…”

Section: Borg Et Al (2010)mentioning

confidence: 99%

“…88 In a group mainly composed of obese women, they compared FPG and HbA 1c with the 2-hour OGTT. Using FPG testing alone, 70% of people with IGR would have been missed because most had isolated IGT.…”

Section: Borg Et Al (2010)mentioning

confidence: 99%