A Large-Scale Field Trial for the Evaluation and Assessment of Malathion as an Insecticide for Antimalarial Work in Southern Uganda

Nájera, J. A.; Shidrawi, G. R.; Gibson, F. D.; Stafford, Joel

doi:10.1080/04345546709415220

Cited by 5 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Between 1963 and 1964, with the assistance of the WHO, a large-scale field trial of malathion was carried out in Masaka district [ 18 ]. The area of intervention covered 500 sq km and a population of 26,000 inhabitants.…”

Section: Review Findingsmentioning

confidence: 99%

“…However, the persistence of malaria cases and the observation of some infections in infants born after the commencement of spraying were reported as not consistent with the entomological observations. Further epidemiological investigations revealed that there were constant movements of the population in and out of the small intervention area and consequently a high rate of autochthonous cases due to imported infections [ 18 ].…”

Section: Review Findingsmentioning

confidence: 99%

See 1 more Smart Citation

The past, present and future use of epidemiological intelligence to plan malaria vector control and parasite prevention in Uganda

Talisuna

Noor

Okui

et al. 2015

Malar J

View full text Add to dashboard Cite

BackgroundAn important prelude to developing strategies to control infectious diseases is a detailed epidemiological evidence platform to target cost-effective interventions and define resource needs.MethodsA review of published and un-published reports of malaria vector control and parasite prevention in Uganda was conducted for the period 1900–2013. The objective was to provide a perspective as to how epidemiological intelligence was used to design malaria control before and during the global malaria eradication programme (GMEP) and to contrast this with the evidence generated in support of the Roll Back Malaria (RBM) initiative from 1998 to date.ResultsDuring the GMEP era, comprehensive investigations were undertaken on the effectiveness of vector and parasite control such as indoor residual house-spraying (IRS) and mass drug administration (MDA) at different sites in Uganda. Nationwide malariometric surveys were undertaken between 1964 and 1967 to provide a profile of risk, epidemiology and seasonality leading to an evidence-based national cartography of risk to characterize the diversity of malaria transmission in Uganda. At the launch of the RBM initiative in the late 1990s, an equivalent level of evidence was lacking. There was no contemporary national evidence-base for the likely impact of insecticide-treated nets (ITN), no new malariometric data, no new national cartography of malaria risk or any evidence of tailored intervention delivery based on variations in the ecology of malaria risk in Uganda.DiscussionDespite millions of dollars of overseas development assistance over the last ten years in ITN, and more recently the resurrection of the use of IRS, the epidemiological impact of vector control remains uncertain due to an absence of nationwide basic parasite and vector-based field studies.ConclusionReadily available epidemiological data should become the future business model to maximize malaria funding from 2015. Over the next five to ten years, accountability, impact analysis, financial business cases supported by a culture of data use should become the new paradigm by which malaria programmes, governments and their development partners operate.

show abstract

Section: Review Findingsmentioning

confidence: 99%

Section: Review Findingsmentioning

confidence: 99%

The past, present and future use of epidemiological intelligence to plan malaria vector control and parasite prevention in Uganda

Talisuna

Noor

Okui

et al. 2015

Malar J

View full text Add to dashboard Cite

show abstract

“…Organophosphate and carbamate insecticides are the main alternatives to pyrethroids for controlling malaria vectors (White, 1999; Najera & Zaim, 2002), having worked well for IRS in some situations (Najera et al ., 1967; Fontaine et al ., 1978) but not others (Kouznetsov, 1977; Molineaux & Gramiccia, 1980). In Burkina Faso, IRS with the carbamate carbosulfan resulted in more than 94% mortality of An.…”

Section: Introductionmentioning

confidence: 98%

Resistance to carbosulfan in Anopheles gambiae from Ivory Coast, based on reduced sensitivity of acetylcholinesterase

N’Guessan¹,

Darriet

Guillet

et al. 2003

Medical Vet Entomology

102

View full text Add to dashboard Cite

Abstract. Resistance to carbosulfan, a carbamate insecticide, was detected in field populations of the malaria vector mosquito Anopheles gambiae Giles (Diptera: Culicidae) from two ecologically contrasted localities near BouakeÂ , Ivory Coast: rural M'beÂ with predominantly M form of An. gambiae susceptible to pyrethroids; suburban Yaokoffikro with predominantly S form of An. gambiae highly resistant to pyrethroids (96% kdr). The discriminating concentration of 0.4% carbosulfan (i.e. double the LC 100 ) was determined from bioassays with the susceptible An. gambiae Kisumu strain. Following exposure to the diagnostic dosage (0.4% carbosulfan for 1 h), mortality rates of female An. gambiae adults (reared from larvae collected from ricefields) were 62% and 29% of those from M'beÂ and Yaokoffikro, respectively, 24 h post-exposure. Exposure for 3 min to netting impregnated with the operational dosage of carbosulfan 200 mg/m 2 gave mortality rates of 88% of those from M'beÂ and only 12.2% for Yaokoffikro. In each case the control untreated mortality rate was insignificant. Biochemical assays to detect possible resistance mechanism(s) revealed the presence of insensitive AChE in populations of An. gambiae at both localities, more prevalent in the S form at Yaokoffikro than in M form at M'beÂ , as expected from bioassays results. Our study demonstrates the need to monitor carbamate resistance among populations of the An. gambiae complex in Africa, to determine its spread and anticipate vector control failure if these insecticides are employed.

show abstract

“…Carbamates and organophosphates have shown a relatively good efficacy in ITNs and IRS [42][43][44][45] with high mortality of pyrethroids-resistant [46] An. gambiae s.s in Côte d'Ivoire [47].…”

Section: Introductionmentioning

confidence: 99%

Phenotypic effects of concomitant insensitive acetylcholinesterase ( ace-1 R ) and knockdown resistance ( kdr R ) in Anopheles gambiae : a hindrance for insecticide resistance management for malaria vector control

Assogba

Djogbénou

Saizonou

et al. 2014

Parasites & Vectors

View full text Add to dashboard Cite

show abstract

A Large-Scale Field Trial for the Evaluation and Assessment of Malathion as an Insecticide for Antimalarial Work in Southern Uganda

Cited by 5 publications

References 0 publications

The past, present and future use of epidemiological intelligence to plan malaria vector control and parasite prevention in Uganda

The past, present and future use of epidemiological intelligence to plan malaria vector control and parasite prevention in Uganda

Resistance to carbosulfan in Anopheles gambiae from Ivory Coast, based on reduced sensitivity of acetylcholinesterase

Phenotypic effects of concomitant insensitive acetylcholinesterase ( ace-1 R ) and knockdown resistance ( kdr R ) in Anopheles gambiae : a hindrance for insecticide resistance management for malaria vector control

Contact Info

Product

Resources

About