A Large-Scale Study of MT1–MMP as a Marker for Isolated Tumor Cells in Peripheral Blood and Bone Marrow in Gastric Cancer Cases

Mimori, Koshi; Fukagawa, Takeo; Kosaka, Yoshimasa; Ishikawa, Kenji; Iwatsuki, Masaaki; Yokobori, Takehiko; Hirasaki, Shigeo; Takatsuno, Yasushi; Sakashita, Hiroyuki; Ishii, Hideshi; Sasako, Mitsuru; Mori, Masaki

doi:10.1245/s10434-008-9916-z

Cited by 53 publications

(61 citation statements)

References 18 publications

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“…MMPs are usually relatively inactive, and can be activated when tissues are undergoing repair or remodeling, or in disease or inflammation (9). It has been reported that repressing the expression of certain MMPs is associated with increased survival and favorable prognosis in GC patients (10)(11)(12). MMPs can be specifically regulated by tissue inhibitors of metalloproteinases (TIMPs).…”

Section: Degradation Of the Ecmmentioning

confidence: 99%

Molecular background of the regional lymph node metastasis of gastric cancer (Review)

Zhu

Hu²,

Wei

et al. 2018

Oncol Lett

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Abstract. Gastric cancer (GC) is one of the deadliest types of cancer in the world. Lymph node (LN) metastasis is a complex and malignant behavior of GC, involving a sequence of biological processes, including decreased adherence to adjacent cells, extracellular matrix (ECM) degradation and lymphatic channel permeation. LN metastasis is directly associated with the treatment response, local recurrence and long-term survival of patients with GC. Therefore, the molecular mechanisms of LN metastasis in GC development require further investigation. Recently, a large number of clinical studies have focused on the molecular mechanisms and biological markers of tumor invasion and metastasis. However, few articles have broadly summarized LN metastasis in GC, and the molecular mechanisms of LN metastasis are not yet fully understood. In the present review, the molecular mechanisms of LN metastasis in GC will be discussed, including the following aspects: Cell adhesion and movement, ECM degradation, new vessel formation, and molecular pattern differences between metastatic LNs and the primary tumor. This review may lead to a better understanding of LN metastasis in GC, and the identification of new diagnostic markers.

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Section: Degradation Of the Ecmmentioning

confidence: 99%

Molecular background of the regional lymph node metastasis of gastric cancer (Review)

Zhu

Hu²,

Wei

et al. 2018

Oncol Lett

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“…The level of MMP7 in peritoneal lavage was detected using RT-PCR and the results demonstrated that MMP7 expression is associated with peritoneal metastasis, for which the sensitivity was 53.3% (40). In addition, the expression of MMP14, as detected using RT-PCR of peripheral blood and bone marrow samples, is associated with peritoneal dissemination in gastric cancer (41). MMPs are suppressed by tissue inhibitor metalloproteinases (TIMPs) (42).…”

Section: Invasion Into Subperitoneal Tissuementioning

confidence: 99%

Mechanisms of peritoneal dissemination in gastric cancer (Review)

2017

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Abstract. Peritoneal dissemination is the most frequent metastatic pattern of gastric cancer, but the mechanisms underlying peritoneal dissemination are yet to be elucidated. Paget's 'seed and soil' hypothesis is recognized as the fundamental theory of metastasis. The 'seeding' theory proposes that the formation of peritoneal dissemination is a multistep process, including detachment from the primary tumour, transmigration and attachment to the distant peritoneum, invasion into subperitoneal tissue and proliferation with blood vascular neogenesis. In the present review, the progress of each step is discussed. Milky spots, as a lymphatic apparatus, are indicative of lymphatic orifices on the surface of the peritoneum. These stomata are open gates for peritoneal-free cancer cells to migrate into the submesothelial space. Therefore, milky spots provide suitable 'soil' for cancer cells to implant. Other theories have also been proposed to clarify the peritoneal dissemination process, including the transvessel metastasis theory, which suggests that the peritoneal metastasis of gastric cancer develops via a vascular network mediated by hypoxia inducible factor-1α.

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“…MT1-MMP-positive expression in peripheral blood was associated with incidence of peritoneal dissemination, lymphatic permeation, vascular permeation, and lymphonode metastasis. MT1-MMP-positive expression in bone marrow was also significantly related to the incidence of distant metastasis and peritoneal dissemination (Mimori et al, 2008). MT1-MMP plays an important role in the progression of the laryngeal cancer, and may serve as a reliable marker in estimating invasive and metastatic potency of laryngeal cancer (Sun and Li, 2004).…”

Section: Tumorigenesismentioning

confidence: 99%

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

Sbardella

Fasciglione

Gioia

et al. 2012

Molecular Aspects of Medicine

210

212

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a b s t r a c tHuman matrix metalloproteinases (MMPs) belong to the M10 family of the MA clan of endopeptidases. They are ubiquitarian enzymes, structurally characterized by an active site where a Zn 2+ atom, coordinated by three histidines, plays the catalytic role, assisted by a glutamic acid as a general base. Various MMPs display different domain composition, which is very important for macromolecular substrates recognition. Substrate specificity is very different among MMPs, being often associated to their cellular compartmentalization and/or cellular type where they are expressed. An extensive review of the different MMPs structural and functional features is integrated with their pathological role in several types of diseases, spanning from cancer to cardiovascular diseases and to neurodegeneration. It emerges a very complex and crucial role played by these enzymes in many physiological and pathological processes.

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A Large-Scale Study of MT1–MMP as a Marker for Isolated Tumor Cells in Peripheral Blood and Bone Marrow in Gastric Cancer Cases

Abstract: The expression of MT1-MMP in peripheral blood from gastric cancer cases was a powerful indicator of distant metastasis especially for peritoneal dissemination. The presence of MT1-MMP-expressing cells in bone marrow indicated higher risk for distant metastasis in gastric cancer cases.

Cited by 53 publications

References 18 publications

Molecular background of the regional lymph node metastasis of gastric cancer (Review)

Molecular background of the regional lymph node metastasis of gastric cancer (Review)

Mechanisms of peritoneal dissemination in gastric cancer (Review)

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

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