“…In the last decade, advancements in the field of DNA nanotechnology have enabled the fabrication of a great variety of ‘DNA origami’ nanostructures 1,2 , including transmembrane structures that resemble the biological pores found in cells 3 . Drawing inspiration from protein pores such as alpha-hemolysin 4 , artificial pores have been engineered with DNA origami 1,2 that can insert into lipid bilayers and allow for transmembrane diffusion of ions 5,6 and small molecules such as fluorophores 7,8 , DNA oligomers 5,7 , short PEG 9 , and dextran 8,10 . To favor partitioning into the lipid bilayer, the usual strategy relies on the chemical modification of the outer nanopore surface with hydrophobic groups, e.g.…”