2023
DOI: 10.1101/2023.02.22.529531
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A latent clinical-anatomical dimension relating metabolic syndrome to brain structure and cognition

Abstract: Metabolic syndrome (MetS) describes the clustered prevalence of abdominal obesity, arterial hypertension, dyslipidemia and insulin resistance, collectively promoting cerebrovascular disease. Although this risk factor complex causes a substantial health burden in modern societies, its neural underpinnings remain elusive. To investigate the multivariate association of MetS and cortical thickness, we applied partial least squares (PLS) correlation to a pooled sample of two large-scale population-based cohort stud… Show more

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Cited by 3 publications
(3 citation statements)
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References 138 publications
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“…This association was statistically mediated by the imaging PLS score, which captures the degree of biological brain aging. This implies that the association between vascular risk and cognitive as well as motor abilities is contingent on variations in biological brain aging markers, highlighting the importance of macrostructural and microstructural brain changes in clinical sequelae of agerelated cerebrovascular disease [18,50]. Our results elucidate the connections between vascular risk and both structural and functional brain health, suggesting clinical applications.…”
Section: Biological Brain Aging Mediates the Link Between Vascular Ri...mentioning
confidence: 62%
“…This association was statistically mediated by the imaging PLS score, which captures the degree of biological brain aging. This implies that the association between vascular risk and cognitive as well as motor abilities is contingent on variations in biological brain aging markers, highlighting the importance of macrostructural and microstructural brain changes in clinical sequelae of agerelated cerebrovascular disease [18,50]. Our results elucidate the connections between vascular risk and both structural and functional brain health, suggesting clinical applications.…”
Section: Biological Brain Aging Mediates the Link Between Vascular Ri...mentioning
confidence: 62%
“…Details on the UKB Ethics and Governance framework are provided online ( https://www.ukbiobank.ac.uk/media/0xsbmfmw/egf.pdf ). 15 Data usage is covered by a vote of the ethics committee of the medical faculty of the Heinrich Heine University Düsseldorf.…”
Section: Methodsmentioning
confidence: 99%
“…uk/media/0xsbmfmw/egf.pdf). 15 Data usage is covered by a vote of the ethics committee of the medical faculty of the Heinrich Heine University Düsseldorf.…”
Section: Ethics Approvalmentioning
confidence: 99%