“…Thus, the number of random location effects (ie, 𝝂 i ) no longer plays a role in the approximation. 13,15,16 To derive the restriction, we exploit the normality assumption that we made for the random effect vector 𝝓 i and the block diagonal structure of the covariance matrix 𝚽 (see Equation 7). From the properties of the multivariate normal distribution, it follows (see, Reference 32) that the marginal distribution of the scale-related random effects 𝜹 i = (𝜔 i , 𝜅 i ) is a multivariate normal distribution with expectation zero and covariance matrix 𝚽 (𝜔,𝜅) = 𝚽 𝜹 .…”