A Laterally Transferred Viral Gene Modifies Aphid Wing Plasticity

Parker, Benjamin J.; Brisson, Jennifer A.

doi:10.1016/j.cub.2019.05.041

Cited by 73 publications

(83 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therefore, a given genomic region associated with a phenotype of interest that has transferred naturally between species represents a good target sequence to insert in yet another species to obtain a similar trait. An incredible number of transfers of DNA fragments from one species to another, via introgression between closely related species or via horizontal gene transfer, through viruses or yet other unknown means between distantly related species, have been discovered in recent years (Daubin and Szöllosi, 2016;Gasmi et al, 2015;Matveeva and Otten, 2019;Parker and Brisson, 2019;Taylor and Larson, 2019;Wu et al, 2018). For example, adaptation to high altitude occurred independently in Tibetan human populations and in dogs via distinct alleles of the EPAS1 gene, which have been transferred from archaic hominins to humans and from wolves to dogs, respectively (Witt and Huerta-Sánchez, 2019).…”

Section: The Advantages Of Bioinspired Genome Editingmentioning

confidence: 99%

The coding loci of evolution and domestication: current knowledge and implications for bio-inspired genome editing

Courtier‐Orgogozo

Martin

2020

Journal of Experimental Biology

View full text Add to dashboard Cite

One promising application of CRISPR/Cas9 is to create targeted mutations to introduce traits of interest into domesticated organisms. However, a major current limitation for crop and livestock improvement is to identify the precise genes and genetic changes that must be engineered to obtain traits of interest. Here, we discuss the advantages of bio-inspired genome editing, i.e. the engineered introduction of natural mutations that have already been associated with traits of interest in other lineages (breeds, populations or species). To obtain a landscape view of potential targets for genome editing, we used Gephebase (www.gephebase.org), a manually curated database compiling published data about the genes responsible for evolutionary and domesticated changes across eukaryotes, and examined the >1200 mutations that have been identified in the coding regions of more than 700 genes in animals, plants and yeasts. We observe that our genetic knowledge is relatively important for certain traits, such as xenobiotic resistance, and poor for others. We also note that protein-null alleles, often owing to nonsense and frameshift mutations, represent a large fraction of the known loci of domestication (42% of identified coding mutations), compared with intraspecific (27%) and interspecific evolution (11%). Although this trend may be subject to detection, publication and curation biases, it is consistent with the idea that breeders have selected large-effect mutations underlying adaptive traits in specific settings, but that these mutations and associated phenotypes would not survive the vagaries of changing external and internal environments. Our compilation of the loci of evolution and domestication uncovers interesting options for bio-inspired and transgene-free genome editing.

show abstract

Section: The Advantages Of Bioinspired Genome Editingmentioning

confidence: 99%

The coding loci of evolution and domestication: current knowledge and implications for bio-inspired genome editing

Courtier‐Orgogozo

Martin

2020

Journal of Experimental Biology

View full text Add to dashboard Cite

show abstract

“…Although actively replicating viruses and lateral transfers of single genes from viruses into eukaryotic hosts can generate novel phenotypes of key importance (Parker & Brisson 2019;Coffman et al 2020;Aswad & Katzourakis 2012;Dunlap et al 2006;Lavialle et al 2013) , the focus here is upon identification of sets of viral replication genes that could be responsible for the production of virions or VLPs that are permanent key components of wasp biology and parasitism success. Homology searches of all ORFs extracted from genome assembly scaffolds against a custom database produced viral hits for 37 to 75 ORFs for species with previously published genomes, and 10 to 53 ORFs for new species ( Supplementary Figure 1 and 2, Supplementary Table 4).…”

Section: Identification Of Genes Of Viral Origin Using Exhaustive Seqmentioning

confidence: 99%

Endogenization from diverse viral ancestors is common and widespread in parasitoid wasps

Burke

Hines

Sharanowski

2020

Preprint

View full text Add to dashboard Cite

The Ichneumonoidea (Ichneumonidae and Braconidae) is an incredibly diverse superfamily of parasitoid wasps that includes species that produce virus-like entities in their reproductive tracts to promote successful parasitism of host insects. Research on these entities has traditionally focused upon two viral genera Bracovirus (in Braconidae) and Ichnovirus (in Ichneumonidae). These viruses are produced using genes known collectively as endogenous viral elements (EVEs) that represent historical, now heritable viral integration events in wasp genomes. Here, new genome sequence assemblies for eleven species and six publicly available genomes from the Ichneumonoidea were screened with the goal of identifying novel EVEs and characterizing the breadth of species in lineages with known EVEs. Exhaustive similarity searches combined with the identification of ancient core genes revealed sequences from both known and novel EVEs. Two species harbored novel, independently derived EVEs related to a divergent large DNA (dsDNA) virus that manipulates behavior in other hymenopteran species. While bracovirus or ichnovirus EVEs were identified as expected in three species, the absence of ichnoviruses in several species suggests that they are independently derived and present in two younger, less widespread lineages than previously thought. Overall, this study presents a novel bioinformatic approach for EVE discovery in genomes and shows that three divergent virus families (nudiviruses, the ancestors of ichnoviruses, and LbFV-like viruses) are recurrently acquired as EVEs in parasitoid wasps. Virus acquisition in the parasitoid wasps is a common process that has occurred in many more than two lineages from a diverse range of arthropod-infecting dsDNA viruses. SignificanceParasitoid wasps are an extremely diverse group of animals that are known to harbor Endogenous Virus Elements (EVEs) that produce virions or virus-like particles of key importance in wasps' parasitism success. However, the prevalence and diversity of independently acquired EVEs in parasitoid wasp lineages has remained largely uncharacterized on a widespread scale. This study represents an important first step and hints at the massive, untapped diversity of EVEs in parasitoid wasps via the identification of several novel virus co-option events from diverse groups of double-stranded DNA virus pathogens.

show abstract

“…Research exploring such effects has primarily focused on implications for disease transmission [2][3][4] ; however, pathogen effects on the phenotypes of hosts and vectors can also influence the ways in which these species interact with other organisms 1 . Yet, despite increasing recognition that pathogens and other microbial symbionts often have profound effects on the phenotypes of their hosts, the implications of such effects for interspecific and community-level interactions are only beginning to be explored [9][10][11][12][13] .…”

mentioning

confidence: 99%

“…An extensive literature addresses the evolution of host manipulation by parasites [2][3][4][5][6][7][8][10][11][12][13][14][15] , and increased attention has recently focused on the manipulative effects of vector-transmitted microbial pathogens 14,15 . It is now clear that pathogens frequently influence host-vector interactions both through direct effects on vectors (e.g., via alteration of feeding behaviors [16][17][18] ) and through effects on primary hosts that influence host-vector interactions [2][3][4][5] .…”

mentioning

confidence: 99%

Enhanced heat tolerance of viral-infected aphids leads to niche expansion and reduced interspecific competition

et al. 2020

View full text Add to dashboard Cite

Vector-borne pathogens are known to alter the phenotypes of their primary hosts and vectors, with implications for disease transmission as well as ecology. Here we show that a plant virus, barley yellow dwarf virus, increases the surface temperature of infected host plants (by an average of 2°C), while also significantly enhancing the thermal tolerance of its aphid vector Rhopalosiphum padi (by 8°C). This enhanced thermal tolerance, which was associated with differential upregulation of three heat-shock protein genes, allowed aphids to occupy higher and warmer regions of infected host plants when displaced from cooler regions by competition with a larger aphid species, R. maidis. Infection thereby led to an expansion of the fundamental niche of the vector. These findings show that virus effects on the thermal biology of hosts and vectors can influence their interactions with one another and with other, non-vector organisms.

show abstract

A Laterally Transferred Viral Gene Modifies Aphid Wing Plasticity

Cited by 73 publications

References 33 publications

The coding loci of evolution and domestication: current knowledge and implications for bio-inspired genome editing

The coding loci of evolution and domestication: current knowledge and implications for bio-inspired genome editing

Endogenization from diverse viral ancestors is common and widespread in parasitoid wasps

Enhanced heat tolerance of viral-infected aphids leads to niche expansion and reduced interspecific competition

Contact Info

Product

Resources

About