2022
DOI: 10.1101/2022.10.13.511617
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A Leaky Human Colon Model Reveals Uncoupled Apical/Basal Cytotoxicity in EarlyClostridioides difficileToxin Exposure

Abstract: Background & Aims:Clostridioides difficile(C. difficile) toxins A (TcdA) and B (TcdB) cause antibiotic-associated colitis and increase morbidity and mortality. Accurate in vitro models are necessary to detect early toxicity kinetics, investigate disease etiology, and develop pre-clinical models for new therapies. Properties of cancer cell lines and 3D organoids inherently limit these efforts. Here, we develop adult stem cell-derived monolayers of differentiated human colonic epithelium (hCE) with barrier f… Show more

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