A Leeward Look

James, V. Bose

doi:10.1515/9783110870541-004

Cited by 2 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…as two major ApoA-l-conraining lipoprotein families. The chemical anc metabolic uniqueness of these two lipoprotein ram[lie: has been demonstrated by several independent studie~ [26][27][28][29][30][31][32][33][34]. The present report confirms and extends previous observations [37][38][39][40] of a third minor Al;oA-containing lipoprotein family, LP-A-II, characterized b) ApoA-ll as its major protein constituent.…”

Section: Discussionsupporting

confidence: 82%

“…Among these lipoprotein particles identified and diff,:rentiated on the bas;s of their apotipoprotein composition [24], ApoA-ll mainly occurs in association with ApoA-I as lipoprotein A-! :A-ll (LP-A-I :A-II) [28][29][30][31][32][33][34]. The LP-A-I:A-I] family is a polydisperse system of particles present throughout the HDL density range with the major part occurring in the HDL 3 subfraction [33,35].…”

mentioning

confidence: 99%

“…:A-ll (LP-A-I :A-II) [28][29][30][31][32][33][34]. The LP-A-I:A-I] family is a polydisperse system of particles present throughout the HDL density range with the major part occurring in the HDL 3 subfraction [33,35]. Another" lipoprotein form of ApoA-ll has been recently identified and characterized as lipoprotein All:B:C:D:E (LP-A-II:B:C:D:E (~r LP-A-II:B complex) in VLDL of patients with Tane.ier disease or phengtype V hyperlipoproteinemia [36].…”

mentioning

confidence: 99%

See 2 more Smart Citations

Isolation and partial characterization of lipoprotein A-II (LP-A-II) particles of human plasma

Bekaert

Alaupovic

Knight-Gibson

et al. 1992

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metaboli

View full text Add to dashboard Cite

High density lipoproteins (HDL) consist of a mixture of chemically and functionally distinct families of particles defined by their characteristic apolipoprotein (Apo) composition. The two major lipoprotein families are lipoprotein A-I (LP-A-I) and lipoprotein A-I:A-II (LP-A-I:A-II). This study describes the isolation of a third minor HDL family of particles referred to as lipoprotein A-II (LP-A-II) because it lacks ApoA-I and contains ApoA-II as its main or sole apolipoprotein constituent. Because ApoA-II is an integral protein constituent of three distinct lipoprotein families (LP-A-I:A-II, LP-A-II: B:C:D:E and LP-A-II), LP-A-II particles were isolated from whole plasma by sequential immunoaffinity chromatography on immunosorbers with antisera to ApoA-II, ApoB and ApoA-I, respectively. In normolipidemic subjects, the concentration of LP-A-II particles, based on ApoA-II content, is 4-18 mg/dl accounting for 5-20% of the total ApoA-II not associated with ApoB-containing lipoproteins. The lipid composition of LP-A-II particles is characterized by low percentage of triglycerides and cholesterol esters and a high percentage of phospholipids in comparison with lipid composition of LP-A-I and LP-A-II: A-II. The major part of LP-A-II particles contain ApoA-II as the sole apolipoprotein constituent; however, small subsets of LP-A-II particles may also contain ApoD and other minor apolipoproteins. The lipid/protein ratio of LP-A-II is higher than those of LP-A-I and LP-A-I:A-II. In homozygous ApoA-I and ApoA-I/ApoC-III deficiencies, LP-A-II particles are the only ApoA-containing high density lipoprotein with levels found to be within the same range (7-13 mg/dl) as those of normolipidemic subjects. However, in contrast to normal LP-A-II, their lipid composition is characterized by higher percentages of triglycerides and cholesterol esters and a lower percentage of phospholipids and their apolipoprotein composition by the presence of ApoC-peptides and ApoE in addition to ApoA-II and ApoD. These results show that LP-A-II particles are a minor HDL family and suggest that, in the absence of ApoA-I-containing lipoproteins, they become an efficient acceptor/donor of ApoC-peptides and ApoE required for a normal metabolism of triglyceride-rich lipoproteins. Their other possible functional roles in lipid transport remain to be established in future experiments.

show abstract

Section: Discussionsupporting

confidence: 82%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Isolation and partial characterization of lipoprotein A-II (LP-A-II) particles of human plasma

Bekaert

Alaupovic

Knight-Gibson

et al. 1992

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metaboli

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

“…From the perspective of modern monetary theory, American debt has a certain influence on financial markets [2]. For instance, within a few years, it may have serious negative impacts on science [2]. In order to avoid a large amount of government debt and insolvency, the government usually reduces its borrowing behavior during economic recession, while the member countries of the OECD, just as the U.S., will increase the Debt limit to affect the depressed market [2].…”

Section: Introductionmentioning

confidence: 99%

Unveiling the Future: Forecasting the US Debt Ceiling and Financial Market Trends

Chen,

Song,

Wang

2024

SHS Web Conf.

View full text Add to dashboard Cite

The US debt limit has important implications for economic and financial stability. By analyzing historical data, this article finds that there is a significant correlation between the debt limit and the US financial market. The article also constructs an exponential smoothing mathematical model to successfully predict the debt limit in the future and test the accuracy of the model using historical data. The results show that the debt limit has a significant positive linear correlation with the S&P 500 Index and the Spot Gold Price Index. Although there is no linear correlation between the debt limit and the dollar index, this paper finds a hidden pattern by comparing the data of the Democratic and Republican administrations. Based on the results of the projections of the debt limit for the next five years and the correlation with the three major indices, the article makes a reasonable prediction of the future trend of the US financial market and provide insights. These results suggest that the situation in the United States may be more optimistic than expected.

show abstract

A Leeward Look

Cited by 2 publications

References 0 publications

Isolation and partial characterization of lipoprotein A-II (LP-A-II) particles of human plasma

Isolation and partial characterization of lipoprotein A-II (LP-A-II) particles of human plasma

Unveiling the Future: Forecasting the US Debt Ceiling and Financial Market Trends

Contact Info

Product

Resources

About