A leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y was not identified in the Japanese population

Makino, Kazutaka; Kataoka, Yasufumi; Hirakawa, Yoshihiro; Ikeda, Akio; Yamauchi, Atsushi; Oishi, And R.

doi:10.1046/j.1365-2710.2001.00346.x

Cited by 22 publications

(11 citation statements)

References 9 publications

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“…15,25,26 Irreproducibility of positive findings has been a common criticism levelled at association studies investigating the common genetic basis of complex diseases. 22 The frequency of the Pro7 allele has been reported to be 0.08 in Finns, 0.03 in Dutchmen 17 and virtually absent in Japanese 28,29 and Koreans. 30 An extremely low frequency of Pro7 was observed in a Chinese population, 31 whereas Duan et al 32 failed to detect this allele in the same region.…”

Section: Discussionmentioning

confidence: 99%

Neuropeptide Y gene functional polymorphism influences susceptibility to hypertension in Indian population

et al. 2009

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Hypertension is an independent determinant of cardiovascular risk, a phenotype that usually has a strong genetic component. Neuropeptide Y (NPY) plays an important role in BP homeostasis. The aim of this study was to investigate the possible influence of NPY polymorphisms on hypertension in a South Indian population. A total of 252 subjects (132 controls and 120 hypertensives) were analysed for T1128C, G1258A and A7735G polymorphisms in the NPY gene. Body mass index (BMI), pulse, SBP and DBP were assessed. Direct sequencing of PCR products was adopted for genotyping. All three polymorphisms were found to be in Hardy-Weinberg equilibrium. Additive, dominant and recessive models were tested using multivariate regression analysis. The results of our study reveal a significant association between T1128C and hypertension even after adjusting for age, sex and BMI. The adjusted OR (95% confidence interval) for the recessive model was 0.56 (0.33-0.95). The other two polymorphic sites (G1258A and A7735G) are not associated with hypertension. The Pro7 allele of the T1128C polymorphic site-containing haplotype (CGA) is associated with hypertension (P ¼ 0.049), but the combined haplotypes did not show any evidence of haplotype-phenotype association (global P ¼ 0.129). These data support the hypothesis that hypertension is influenced by the NPY T1128C polymorphism.

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Section: Discussionmentioning

confidence: 99%

Neuropeptide Y gene functional polymorphism influences susceptibility to hypertension in Indian population

et al. 2009

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“…The Pro7 allele has already been found in a few populations worldwide, such as Asians [Japanese (Drube et al 2001;Makino et al 2001;Okubo et al 2001;Lappalainen et al 2002;Itokawa et al 2003); Koreans (Ding et al 2002); Japanese in Tokyo and Han, Chinese in Beijing (http://www.hapmap.org)] and Africans [African-American (Lappalainen et al 2002); Yoruba in Ibadan, Nigeria (http://www.hapmap.org)]. Jia et al (2005) reported an extremely low frequency of Pro7 in a Chinese population, although Duan et al (2005) failed to detect this allele in the same region.…”

Section: Discussionmentioning

confidence: 99%

“…There was no report of the presence of this allele among Japanese (Drube et al 2001;Makino et al 2001;Itokawa et al 2003) and Korean populations (Ding et al 2002). Jia et al (2005) reported an extremely low frequency of the Pro7 allele in China.…”

Section: Introductionmentioning

confidence: 99%

Allelic variation in the NPY gene in 14 Indian populations

et al. 2007

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NPY is a 36-aminoacid peptide expressed in several areas of the nervous system. Neuropeptide Y (NPY) receptors represent a widely diffused system that is involved in the regulation of multiple biological functions. The human NPY gene is located in chromosome 7. The functional significance of coding Leu7Pro polymorphism in the signal peptide of preproNPY is known. Six hundred and fifty four individuals of 14 ethnic Indian populations were screened for three mutations in the NPY gene, including Leu7Pro. We found that the Pro7 frequencies among the studied populations were much higher than in previous studies from other parts of the world. The highest allele frequency of Pro7 was detected in the Kota population in the Nilgiri Hill region of south India, and this may reflect a founder event in the past or genetic drift. All populations followed the Hardy-Weinberg equilibrium for the assayed markers. A total of five haplotypes were observed, only two of which were found to occur with a high frequency in all populations. No linkage disequilibrium (LD) was observed across the tested alleles in any population with the exception of Leu7Pro and Ser50Ser in the Badaga population (v 2 = 13.969; p = 0.0001).

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“…In addition, the frequency of the Leu 7 -to-Pro 7 polymorphism appeared to vary from one population to the other, since the incidence in healthy Japanese was extremely low. It is therefore unlikely that NPY represents a strong genetic factor affecting cholesterol among Japanese people [139]. The exact NPY-mediated mechanisms influencing blood lipid concentrations and deposition in the vasculature are unknown.…”

Section: Cardiovascular Regulationmentioning

confidence: 99%

Neuropeptide Y: the universal soldier

Pedrazzini¹,

Pralong

Grouzmann³

2003

Cellular and Molecular Life Sciences (CMLS)

253

158

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The peptidic neuropeptide Y (NPY) has received great attention because it has been implicated in the regulation of several organ systems. In particular, NPY is involved in the regulatory loops that control food intake in the hypothalamus and appears also to be important for regulating the activity of neuroendocrine axes under poor metabolic conditions. Furthermore, NPY exerts vasoconstrictive action on the vasculature and potentiates the actions of many other vasoconstrictors. In addition, it was demonstrated to have trophic properties and could therefore contribute to cardiovascular remodeling. These various effects plus a number of others make NPY an attractive target for the potential treatment of human diseases, such as obesity, metabolic disorders, hypertension and heart failure.

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A leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y was not identified in the Japanese population

Abstract: The incidence of the Leu(7)-to-Pro(7) polymorphism in the signal peptide of NPY was extremely low in Japanese people, suggesting that the polymorphism producing Pro(7) is not one of the genetic determinant factors affecting serum cholesterol levels in Japanese people.

Cited by 22 publications

References 9 publications

Neuropeptide Y gene functional polymorphism influences susceptibility to hypertension in Indian population

Neuropeptide Y gene functional polymorphism influences susceptibility to hypertension in Indian population

Allelic variation in the NPY gene in 14 Indian populations

Neuropeptide Y: the universal soldier

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