A level-set method for ultrasound-driven bubble motion and tissue deformation

Numerical investigation of acoustic cavitation and viscoelastic tissue deformation

“…Further details for spatial and temporal discretization of the governing Eqs. (4) , (5) , (6) and validation tests of the LS formulation for solid deformation and ultrasound-driven bubble motion have been addressed in our previous studies [31] , [37] .…”

“…Full Eulerian methods [28] , [29] , [30] , [31] , which are advantageous for describing large solid deformation without mesh regeneration [32] , [33] , have also been applied to various biological tissues. Ii et al [29] simulated the complex migration and deformation patterns of blood cells in practical intravascular situations by modeling the multiple red blood cells as biconcave capsules and employing the full Eulerian method.…”

“…Their computations successfully represented a variety of lithotripsy situations, neglecting the viscosity and surface tension effects which can be important in the acoustic cavitation dynamics of pre-existing nuclei or microbubbles [27] , [34] . Park and Son [31] performed a preliminary study on ultrasound-driven dodecafluoropentane (DDFP) bubble motion and tissue deformation, which is applicable to medical imaging and therapy, by improving a level-set (LS) method for bubble dynamics under ultrasonic conditions to include the elastic properties of tissue using the full Eulerian method. They investigated the effects of ultrasonic parameters, bubble-tissue distances and shear moduli on bubble-tissue interactions.…”