Introduction The longitudinal integrated clerkship is a model of clinical medical education that is increasingly employed by medical schools around the world. These guidelines are a result of a narrative review of the literature which considered the question of how to maximize the sustainability of a new longitudinal integrated clerkship program. Method All four authors have practical experience of establishing longitudinal integrated clerkship programs. Each author individually constructed their Do's, Don'ts and Don't Knows and the literature that underpinned them. The lists were compiled and revised in discussion and a final set of guidelines was agreed. A statement of the strength of the evidence is included for each guideline. Results The final set of 18 Do's, Don'ts and Don't Knows is presented with an appraisal of the evidence for each one. Conclusion Implementing a longitudinal integrated clerkship is a complex process requiring the involvement of a wide group of stakeholders in both hospi