“…Pearce et al, 2004 studied the effect of birth-weight, early diet, use of comforter and social status on oral health of young adults, but found only effect of social status in the expected direction. Nicolau and co-workers found a relationship between several biological factors and caries among adolescents (Nicolau et al, 2003(Nicolau et al, , 2007. A second line of research assumes biological programming during critical periods of development either during pregnancy or in early life (Barker, 1994).…”