A light addressable electrode with a TiO2 nanocrystalline film for localized electrical stimulation of cultured neurons

Light-addressable Electrodes for Dynamic and Flexible Addressing of Biological Systems and Electrochemical Reactions

“…In another approach, Suzurikawa et al replaced the photoconductive a-Si:H passivation sandwich structure by titanium dioxide [73]. TiO 2 anatase nanoparticles were deposited on a conductive fluorine-doped tin oxide (FTO) glass by spin-coating and subsequent sintering at different temperatures (350 • C, 500 • C and 500 • C with TiCl 2 treatment).…”

Shedding Light on Living Cells

“…Passivation layers against weakly alkaline culture media, such as low‐conductivity zinc antimonite and carbonic silicon oxide, to protect a‐Si:H from corrosion and dissolution, have been properly developed to this goal. More recently, a TiO 2 nanocrystalline film was proposed as a photoconductive substrate for light‐addressed electrical stimulation, and successful stimulation of a primary neuron‐glia co‐culture was reported (1 ms, 1.5 V voltage‐controlled square pulses; 330–380 nm excitation wavelength, 200 mW cm ‐2 power density) . Spatial and temporal resolution has been recently further enhanced by coupling the technique to an inverted confocal microscope …”

A novel and functional assay for pharmacological effects of marine toxins, saxitoxin and tetrodotoxin by cardiomyocyte-based impedance biosensor

“…Cell-based biosensors take cells as the sensitive elements to sense changes in the cellular internal and external environment with high sensitivity and rapid response [24][25][26]. Electrical cell-substrate impedance sensing (ECIS) is a noninvasive and label-free cell-based biosensor technology, which has been successfully applied to monitor cell growth, proliferation, migration, and viability [27][28][29].…”