Current mainstream technologies have exhibited limits in integrating global many-objective optimization methods with chemical production systems, resulting in subpar outcomes in terms of energy efficiency and environmental issues for methanol production systems. In this study, a novel deep learning hybrid framework is proposed, which involves the construction of a mechanism model with the ability to elucidate the underlying principles and interrelationships of chemistry on a macroscopic scale and a data-driven model to enhance the accuracy and dependability of predictions from available data. The efficiency and global search capability of the proposed framework are further improved through the integration of an advanced evolutionary algorithm, which incorporates many-criteria decision-making technology to provide a comprehensive set of trade-offs for the optimal solution sets. The results demonstrate that all four objective functions of carbon dioxide emissions, methane conversion rate, methanol production, and energy consumption in the triple CO 2 feed methanol production system are rapidly optimized, in which carbon dioxide emissions and energy consumption are reduced by 18.50% and 3.15%, respectively. Consequently, this considerably enhances the environment. This proposed framework holds significant potential in facilitating the efficient optimization and sustainable production of complex systems within process engineering.