A lightweight telemetry system for recording neuronal activity in freely behaving small animals

Schregardus, Diederik S.; Pieneman, Anton W.; Maat, A. Ter; Jansen, R. F.; Brouwer, Tinco J. F.; Gahr, Manfred

doi:10.1016/j.jneumeth.2005.12.028

Cited by 43 publications

(35 citation statements)

References 25 publications

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“…In the case of the natively arboreal marmosets, they always attempt to reach the top of any enclosure, including climbing up their own tethers. The ideal solution is the use of a radio telemetry system (Grohrock et al, 1997;Nieder and Klump, 1999;Chien and Jaw, 2005;Mohseni et al, 2005;Jurgens and Hage, 2006;Schregardus et al, 2006). However, few of these systems are commercially available and are small enough for use in the marmoset; most are also limited to a small number of channels.…”

Section: Free-roaming Methodsmentioning

confidence: 99%

Chronic multi-electrode neural recording in free-roaming monkeys

Eliades

Wang

2008

Journal of Neuroscience Methods

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Many behaviors of interest to neurophysiologists are difficult to study under laboratory conditions because such behaviors are often inhibited when an animal is restrained and socially isolated. Even under the best conditions, such behaviors may be sparse enough as to require long duration neural recordings or simultaneous recording of multiple neurons to gather a sufficient amount of data for analysis. We have developed a preparation for chronic, multi-electrode recordings in the auditory cortex of marmoset monkeys, small primates, as well as techniques for neurophysiological recordings when the animals are free-roaming while singly caged in the environment of the monkey colony. In this report, we describe our solutions to overcome the problems associated with chronic recordings in free-roaming animals, where three-dimensional movements present particular challenges.

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Section: Free-roaming Methodsmentioning

confidence: 99%

Chronic multi-electrode neural recording in free-roaming monkeys

Eliades

Wang

2008

Journal of Neuroscience Methods

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“…These electrophysiological techniques must fix the electrode(s) at certain locations within the brain, and thus, anesthesia has been used to minimize movement artifacts and eliminate the induced stress to the animals. For anesthesia-free neural recording, telemetry systems and linear arrays of microelectrodes have been introduced in behaving small animals (Schregardus et al, 2006) and humans (Keller et al, 2009). Electroencephalogram and magnetoencephalogram also provide less-invasive neural measurements and allow concurrent recording with cortical hemodynamics in anesthetized animals (Franceschini et al, 2008) and in conscious humans (Rosengarten and Kaps, 2010;Ou et al, 2009).…”

Section: Why Is Anesthesia Needed?mentioning

confidence: 99%

Anesthesia and the Quantitative Evaluation of Neurovascular Coupling

Masamoto

Kanno²

2012

J Cereb Blood Flow Metab

245

191

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Anesthesia has broad actions that include changing neuronal excitability, vascular reactivity, and other baseline physiologies and eventually modifies the neurovascular coupling relationship. Here, we review the effects of anesthesia on the spatial propagation, temporal dynamics, and quantitative relationship between the neural and vascular responses to cortical stimulation. Previous studies have shown that the onset latency of evoked cerebral blood flow (CBF) changes is relatively consistent across anesthesia conditions compared with variations in the time-to-peak. This finding indicates that the mechanism of vasodilation onset is less dependent on anesthesia interference, while vasodilation dynamics are subject to this interference. The quantitative coupling relationship is largely influenced by the type and dosage of anesthesia, including the actions on neural processing, vasoactive signal transmission, and vascular reactivity. The effects of anesthesia on the spatial gap between the neural and vascular response regions are not fully understood and require further attention to elucidate the mechanism of vascular control of CBF supply to the underlying focal and surrounding neural activity. The in-depth understanding of the anesthesia actions on neurovascular elements allows for better decision-making regarding the anesthetics used in specific models for neurovascular experiments and may also help elucidate the signal source issues in hemodynamic-based neuroimaging techniques.

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“…However, the majority of nervous system research to date has relied on the use of isolated preparations or restrained subjects. While there have been many successful efforts to record neural activity from freely behaving animals [2][3][4][5] , the biorobotic approach provides a valuable tool to allow for nervous system manipulation in order to test systems level neuroscience hypotheses 6 . Simulated nervous systems operating on robots can be experimentally manipulated and allow for the extension of software modeling to the physical world.…”

Section: Introductionmentioning

confidence: 99%

Designing and Implementing Nervous System Simulations on LEGO Robots

Blustein

Rosenthal

Ayers³

2013

JoVE

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We present a method to use the commercially available LEGO Mindstorms NXT robotics platform to test systems level neuroscience hypotheses. The first step of the method is to develop a nervous system simulation of specific reflexive behaviors of an appropriate model organism; here we use the American Lobster. Exteroceptive reflexes mediated by decussating (crossing) neural connections can explain an animal's taxis towards or away from a stimulus as described by Braitenberg and are particularly well suited for investigation using the NXT platform.1 The nervous system simulation is programmed using LabVIEW software on the LEGO Mindstorms platform. Once the nervous system is tuned properly, behavioral experiments are run on the robot and on the animal under identical environmental conditions. By controlling the sensory milieu experienced by the specimens, differences in behavioral outputs can be observed. These differences may point to specific deficiencies in the nervous system model and serve to inform the iteration of the model for the particular behavior under study. This method allows for the experimental manipulation of electronic nervous systems and serves as a way to explore neuroscience hypotheses specifically regarding the neurophysiological basis of simple innate reflexive behaviors. The LEGO Mindstorms NXT kit provides an affordable and efficient platform on which to test preliminary biomimetic robot control schemes. The approach is also well suited for the high school classroom to serve as the foundation for a hands-on inquiry-based biorobotics curriculum. Video LinkThe video component of this article can be found at

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A lightweight telemetry system for recording neuronal activity in freely behaving small animals

Cited by 43 publications

References 25 publications

Chronic multi-electrode neural recording in free-roaming monkeys

Chronic multi-electrode neural recording in free-roaming monkeys

Anesthesia and the Quantitative Evaluation of Neurovascular Coupling

Designing and Implementing Nervous System Simulations on LEGO Robots

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