A Linear <em>B</em>-Spline Threshold Dose-Response Model with Dose-Specific Response Variation Applied to Developmental Toxicity Studies

Abstract

A linear B-spline function was modified to model dose-specific response variation in developmental toxicity studies. In this new model, response variation is assumed to differ across dose groups. The model was applied to a developmental toxicity study and proved to be significant over the previous model of singular response variation.