“…2,9 In contrast, sural SNAP amplitude was used, because its reduction is highly sensitive and specific for the detection of distal axonal polyneuropathies in general, including DP. 7,10,17,27 Late responses such as the H reflex are also very sensitive in detecting DP, 4,26,27 but the H reflex is also a quite sensitive indicator of S-1 radiculopathy (pathology frequently observed in aged diabetic patients). This limiting factor and recommendations by the San Antonio Conference on Diabetic Neuropathy led us to use the F wave as the only late response parameter in our study, although its specificity and diagnostic and trial utility are still open to debate.…”