2024
DOI: 10.1038/s41598-024-60209-0
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A link between circulating immune complexes and acute kidney injury in human visceral leishmaniasis

Gabriela Corrêa-Castro,
Maria Luciana Silva-Freitas,
Ludmila de Paula
et al.

Abstract: Visceral leishmaniasis (VL) is an infectious disease caused by Leishmania infantum. Clinically, VL evolves with systemic impairment, immunosuppression and hyperactivation with hypergammaglobulinemia. Although renal involvement has been recognized, a dearth of understanding about the underlying mechanisms driving acute kidney injury (AKI) in VL remains. We aimed to evaluate the involvement of immunoglobulins (Igs) and immune complexes (CIC) in the occurrence of AKI in VL patients. Fourteen VL patients were eval… Show more

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