A link between helper and suppressor factors and the lymphokines migration inhibition factor and migration stimulation factor

Fox, Roy; Rajaraman, K.

doi:10.1016/0008-8749(81)90424-x

Cited by 20 publications

(9 citation statements)

References 18 publications

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“…A recent paper in which purified subpopulations of human lymphocytes were used provides conflicting evidence-namely, that MIF is produced by Ty or suppressor cells [66]. Tt is difficult to reconcile these results with results from the mouse system [2,28,39] and with our results in man [28]. This is as far as experiments have gone at the present.…”

Section: Cell Source Of Mstfcontrasting

confidence: 75%

“…This is because of our knowledge of lymphocyte markers in this species and because of the extensive experience that is available on the manipulation of subpopulations. Results of experiments using antisera to Lyt antigen to separate subpopulations have recently been reported [28]. Spleen and thymus cells from Swiss Webster ICR mice were separated into enriched subpopulations by means of anti-Lyt-1.2 and anti-Lyt-2.2 antisera.…”

Section: Cell Source Of Mstfmentioning

confidence: 99%

“…In our hands, murine T-helper-enriched populations produce the lymphokine MIF in response to Con A stimulation. However, these supernatants enhance or augment phytohaemagglutinin (PHA)-induced lymphocyte transformation, and, furthermore, this effect is blocked by L-fucose [28].…”

Section: Biological Role Of Lymphokinesmentioning

confidence: 99%

“…M.St.F.-containing supernatants have been examined for suppressor effect, and suppression of in vitro lymphocyte transformation in response to PHA has been found [28]. In previous publications the suppressor effect has been linked to MIF [39,66], but this appears not to be so.…”

Section: Biological Role Of Lymphokinesmentioning

confidence: 99%

“…MIF is synthesized and released by small lymphocytes [7,14], both B and T [56,64,68]. The T cells producing MIF are the Lyt-1.2 subpopulation [2,28], which are the helper T cells. The advances that have occurred in this work will enable further characterization to take place.…”

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confidence: 99%

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Macrophage Migration Stimulation Factor

Fox¹,

MacSween²,

Rajaraman³

1981

Scand J Immunol

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Section: Cell Source Of Mstfcontrasting

confidence: 75%

Section: Cell Source Of Mstfmentioning

confidence: 99%

Section: Biological Role Of Lymphokinesmentioning

confidence: 99%

Section: Biological Role Of Lymphokinesmentioning

confidence: 99%

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Macrophage Migration Stimulation Factor

Fox¹,

MacSween²,

Rajaraman³

1981

Scand J Immunol

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T Lymphocyte Sensitization to Hbcag and T Cell–Mediated Unresponsiveness to Hbsag in Hepatitis B Virus–Related Chronic Liver Disease

et al. 1985

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Using a newly developed indirect T lymphocyte migration inhibition test, cell-mediated immunity to HBsAg and HBcAg was directly and simultaneously examined in a total of 21 patients with HBsAg-positive chronic liver disease (CLD), and in seven subjects whose sera contained anti-HBs (2 previous acute hepatitis B; 4 hepatitis B vaccine recipients and 1 chronic active hepatitis). T cell sensitization to HBcAg was invariably detected in the HBsAg-positive CLD patients tested (12/12), whereas T cell sensitization to HBsAg was not present in any of the patients (0/21). In contrast, T cell sensitization to HBsAg was present in all anti-HBs-positive subjects. These results support the hypothesis that the cellular immune response to HBcAg, rather than to HBsAg, is implicated in the pathogenesis of HBsAg-positive CLD. Moreover, the observation that the addition of T cells from patients with HBsAg-positive CLD to T cells from anti-HBs positive subjects in a ratio of 1 to 9 reversed their sensitization to HBsAg, suggests that a hyperactivity of HBsAg-specific suppressor T cell population may be responsible for persistent HBs antigenemia.

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L-Fucose, D-Mannose, L-Galactose, and Their BSA Conjugates Stimulate Macrophage Migration

Takata

Chida

Gordon

et al. 1987

Journal of Leukocyte Biology

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The effect of selected monosaccharides on the random migration of normal adult rabbit alveolar macrophages (AM) was investigated. It was observed that 10 mM of L-fucose, L-galactose, or D-mannose stimulated AM migration 1.5-2.0 times. In addition, derivatives of L-fucose and D-mannose occupying the carbon-6 position such as L-fucosyl-lactose, D-mannose-6-phosphate, D-mannitol, and mannan enhanced the migration of AM, whereas derivatives of L-fucose and D-mannose in the carbon-1 position produced no migration enhancement. Macrophage migration enhancement activity that was produced spontaneously by spleen cell cultures from normal young rabbits was destroyed by treatment with L-fucosidase. Accordingly, the migration enhancement factor (MEF) found in spleen cell culture supernatants appeared to depend on L-fucose conjugated to some protein carrier because MEF was non-dialyzable. When normal adult AM were treated with L-fucosidase, they lost their responsiveness to migration inhibitory factor (MIF) but retained their responsiveness to MEF. We have interpreted this to mean that the MIF and MEF receptors are distinct. Synthetic MEFs were prepared by conjugating L-fucose, D-mannose, of L-galactose to bovine serum albumin (BSA). It was noted that these sugar-BSA conjugates were about 200 times more effective than the corresponding free sugars in producing migration enhancement. In addition, these sugar-BSA conjugates neutralized MIF activity in a migration inhibition test.

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A link between helper and suppressor factors and the lymphokines migration inhibition factor and migration stimulation factor

Cited by 20 publications

References 18 publications

Macrophage Migration Stimulation Factor

Macrophage Migration Stimulation Factor

T Lymphocyte Sensitization to Hbcag and T Cell–Mediated Unresponsiveness to Hbsag in Hepatitis B Virus–Related Chronic Liver Disease

L-Fucose, D-Mannose, L-Galactose, and Their BSA Conjugates Stimulate Macrophage Migration

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