A link between platelet to lymphocyte ratio and Helicobacter pylori infection

Abstract

Purpose: Chronic Helicobacter pylori gastritis affects two-thirds of the world's population and is one of the most common chronic inflammatory disorders of humans, the infection clearly results in chronic mucosal inflammation in the stomach and duodenum, which, in turn, might lead to abnormalities in gastroduodenal motility and sensitivity and is the most frequent cause of dyspepsia and peptic disease. Some studies showed that there was a correlation between low-grade inflammation as CRP and HP infection. The purpose of this study was to investigate the relationship between the presence of HP infection and platelet/lymphocyte ratio (PLR). Conclusion: Our study indicated, for the first time, a significant association between HP infection and symptoms based on PLR, a simple and reliable indicator of inflammation. Furthermore, there an increase in PLR as the severity of HP increases. K E Y W O R D SHelicobacter pylori, inflammation, peptic disease, platelet/lymphocyte ratio

The utility of peripheral blood leucocyte ratios as biomarkers in infectious diseases: A systematic review and meta-analysis

“…The PLR was incrementally higher in patients with symptomatic H. pylori (mean 155, n = 100), asymptomatic H. pylori (115, n = 100) and healthy controls (108, n = 108; p < 0.001). 52 Infection was diagnosed by urea breath testing then confirmed by gastric biopsy. In a similar study using the same diagnostic criteria, the NLR was higher in patients with H. pylori infection ( n = 50) compared to patients with gastritis of other aetiologies ( n = 50) (5.1 vs 2.9, p < 0.001).…”

The role of the PLR–NLR combination in the prediction of the presence of Helicobacter pylori and its associated complications

“…found PLR level to be higher in HP (+) compared to HP (−) group. [ 24 ] In the same study, PLR level was found to be correlated with symptoms associated with HP. Similarly, PLR level was found to be higher in HP (+) group in our study as well.…”

“…found the NLR level to be higher in HP (+) patients compared with HP (−) patients. [ 24 ] Also, the NLR level was observed to increase as the severity of gastritis associated with HP increased. The results of our study are similar to the study mentioned above.…”

Evaluation of Helicobacter pylori Infection, Neutrophil–Lymphocyte Ratio and Platelet–Lymphocyte Ratio in Dyspeptic Patients

“…When all these studies are evaluated together, PLR is expected to be affected by H. pylori infection, which causes a chronic inflammation. Farah et al have conducted studies on this topic in 2014 and 2017, suggesting that NLR and PLR of H. Pylori-positive patients are higher than H. Pylori-negative patients [27,28]. Shimoyama et al have studied the relationship between NLR-PLR and mortality in the presence of a gastrointestinal perforation, which is a heavy inflammatory case and scales that reflect other inflammatory cases.…”