A Liquid Crystal Polymer-Based Neuromodulation System: An Application on Animal Model of Neuropathic Pain

Min, Kyung Up; Lee, Choong Jae; Jun, Sang Beom; Kim, Jinhyung; Lee, Sung Eun; Shin, Jaewoo; Chang, Jin Woo; Kim, Sung June

doi:10.1111/ner.12093

Cited by 22 publications

(16 citation statements)

References 33 publications

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“…The solid mechanics interface is used to quantify and characterize the stress and displacement. The material properties are set with ULTRALAM 3850 LCP sheet from Roger Corporation [8] and listed in Table 1. A fixed constraint is applied to the bottom of the device to avoid the displacement of the overall part.…”

Section: Methodsmentioning

confidence: 99%

“…LCP is an appealing material for this application as it is biocompatible, has low moisture absorption and it has a wide range of chemical resistances. Reported applications of LCP in a biological environment include: the use of LCP as a flexible electrode for neural stimulation [8][9][10], as an interconnect for an implanted device [11], and as packaging for an implantable sensor [12]. Given that medical grade LCP sheet is easily available [13], it is an attractive material for the minimally invasive measurement of ICP.…”

Section: Introductionmentioning

confidence: 99%

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Sensitivity and packaging improvement of an LCP pressure sensor for intracranial pressure measurement via FEM simulation

Sattayasoonthorn

Suthakorn

Chamnanvej

2019

IJECE

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A biocompatible liquid crystal polymer (LCP) pressure sensor is proposed for measuring intracranial pressure (ICP) in Traumatic Brain Injury (TBI) patients. Finite element method using COMSOL multiphysics is employed to study the mechanical behavior of the packaged LCP pressure sensor in order to optimize the sensor design. A 3D model of the 8x8x0.2 mm LCP pressure sensor is simulated to investigate the parameters that significantly influence the sensor characteristics under the uniform pressure range of 0 to 50 mmHg. The simulation results of the new design are compared to the experimental results from a previous design. The result shows that reducing the thickness of the sensing membrane can increase the sensitivity up to six times of that previously reported. An improvement of fabrication methodology is proposed to complete the LCP packaging.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sensitivity and packaging improvement of an LCP pressure sensor for intracranial pressure measurement via FEM simulation

Sattayasoonthorn

Suthakorn

Chamnanvej

2019

IJECE

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“…The scalp was opened and the skull was exposed. To place the electrode on the left hindlimb area of the primary motor cortex [20], we made a rectangular hole (2.0 mm × 2.0 mm). The coordination was from −0.2 to +1.8 mm from the Bregma and from 0.5 to 2.5 mm from the midline.…”

Section: Methodsmentioning

confidence: 99%

Rostral Agranular Insular Cortex Lesion with Motor Cortex Stimulation Enhances Pain Modulation Effect on Neuropathic Pain Model

et al. 2016

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It is well known that the insular cortex is involved in the processing of painful input. The aim of this study was to evaluate the pain modulation role of the insular cortex during motor cortex stimulation (MCS). After inducing neuropathic pain (NP) rat models by the spared nerve injury method, we made a lesion on the rostral agranular insular cortex (RAIC) unilaterally and compared behaviorally determined pain threshold and latency in 2 groups: Group A (NP + MCS; n = 7) and Group B (NP + RAIC lesion + MCS; n = 7). Also, we simultaneously recorded neuronal activity (NP; n = 9) in the thalamus of the ventral posterolateral nucleus and RAIC to evaluate electrophysiological changes from MCS. The pain threshold and tolerance latency increased in Group A with “MCS on” and in Group B with or without “MCS on.” Moreover, its increase in Group B with “MCS on” was more than that of Group B without MCS or of Group A, suggesting that MCS and RAIC lesioning are involved in pain modulation. Compared with the “MCS off” condition, the “MCS on” induced significant threshold changes in an electrophysiological study. Our data suggest that the RAIC has its own pain modulation effect, which is influenced by MCS.

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“…1) 26,32 that covers the hindlimb area of the right primary motor cortex. 12 One week after pain induction surgery, rats were anesthetized using pentobarbital sodium (50 mg/kg, intraperitoneally) and fixed using a stereotactic frame (Narishige).…”

Section: Electrical Stimulationmentioning

confidence: 99%

“…After all the procedures had been performed, the scalp was secured with sutures. 32 For the electrical stimulation of the motor cortex, we stimulated each rat's primary motor cortex at a frequency of 130 Hz, for 60 msec, at an amplitude of 2.5 V, and the stimulation parameters were simultaneously monitored using an oscilloscope (HDS1022 M-N, Lilliput Technol- ogy Co., Ltd.). Behavioral tests for pain threshold were performed.…”

Section: Electrical Stimulationmentioning

confidence: 99%

Motor cortex stimulation and neuropathic pain: how does motor cortex stimulation affect pain-signaling pathways?

Kim

Ryu

Lee

et al. 2016

JNS

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N europathic pain is often severe, and it can afflict patients for their entire lifetime. It can be caused by direct damage to the nervous system, and by neuronal degeneration. 7,8 Patients with degenerative diseases such as Parkinson's disease or dementia may experience neuropathic pain as a complication. Many studies have found that neuropathic pain can be induced by indirect nerve damage, but the mechanisms have not yet been clearly established. 7,8,29 The symptoms of neuropathic pain differ among patients, making treatment difficult.31 Although many studies of neuropathic pain and its control have been conducted, the mechanisms behind neuropathic pain are still not clear.Motor cortex stimulation (MCS) is a treatment modality used to modulate neuropathic pain by electrical stimulation. It was introduced in 1991 by Tsubokawa et al. and has since been used in clinical practice.46,47 MCS has advantages for clinicians and patients: MCS is simpler and easier to implement for pain modulation than other surgical methods, such as direct nerve stimulation and neurectomy, and can be considered an alternative for pain control. Among the many modalities involving electrical obJective Neuropathic pain is often severe. Motor cortex stimulation (MCS) is used for alleviating neuropathic pain, but the mechanism of action is still unclear. This study aimed to understand the mechanism of action of MCS by investigating pain-signaling pathways, with the expectation that MCS would regulate both descending and ascending pathways. methods Neuropathic pain was induced in Sprague-Dawley rats. Surface electrodes for MCS were implanted in the rats. Tactile allodynia was measured by behavioral testing to determine the effect of MCS. For the pathway study, immunohistochemistry was performed to investigate changes in c-fos and serotonin expression; micro-positron emission tomography (mPET) scanning was performed to investigate changes of glucose uptake; and extracellular electrophysiological recordings were performed to demonstrate brain activity. results MCS was found to modulate c-fos and serotonin expression. In the mPET study, altered brain activity was observed in the striatum, thalamic area, and cerebellum. In the electrophysiological study, neuronal activity was increased by mechanical stimulation and suppressed by MCS. After elimination of artifacts, neuronal activity was demonstrated in the ventral posterolateral nucleus (VPL) during electrical stimulation. This neuronal activity was effectively suppressed by MCS. coNclusioNs This study demonstrated that MCS effectively attenuated neuropathic pain. MCS modulated ascending and descending pain pathways. It regulated neuropathic pain by affecting the striatum, periaqueductal gray, cerebellum, and thalamic area, which are thought to regulate the descending pathway. MCS also appeared to suppress activation of the VPL, which is part of the ascending pathway.

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A Liquid Crystal Polymer-Based Neuromodulation System: An Application on Animal Model of Neuropathic Pain

Cited by 22 publications

References 33 publications

Sensitivity and packaging improvement of an LCP pressure sensor for intracranial pressure measurement via FEM simulation

Sensitivity and packaging improvement of an LCP pressure sensor for intracranial pressure measurement via FEM simulation

Rostral Agranular Insular Cortex Lesion with Motor Cortex Stimulation Enhances Pain Modulation Effect on Neuropathic Pain Model

Motor cortex stimulation and neuropathic pain: how does motor cortex stimulation affect pain-signaling pathways?

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