Optimal ventilation strategies are fundamental to achieve net/nearly-zero energy buildings. In this study, three hybrid ventilation control strategies are proposed to minimize the cooling need in an open-plan office building, located in the center of Glasgow (Scotland). The performance of the three proposals is assessed by IDA ICE (a whole building performance simulation tool) and compared to a traditional fully mechanical ventilation system. The performance comparison includes different criteria, i.e., indoor temperature and predicted percentage of dissatisfied (PPD) for assessing the indoor comfort, and CO 2 level for assessing the indoor air quality (IAQ). The results show that the three proposed hybrid ventilation strategies are able to minimize the cooling need to zero. They can also imply a drastic reduction of AHU heating power, compared with a mechanical ventilation system without heat recovery (or with low efficiency heat recovery). In addition, they significantly save the fan energy. The only drawback of the proposed strategies is that they might increase space heating demand. For instance, the first and second strategies save about 75 and 50% of AHU (air handling unit) fan energy; however, the space heating increases by about 4.2 and 2.2 kWh/m 2 a, respectively. The third strategy features as the best proposal because it saves around 68% of fan energy with less increase (1.3 kWh/m 2 a) in heating demand. Moreover, it ensures higher thermal comfort and IAQ levels compared to the first and second proposals.