A Literature Review of Senile Pruritus: From Diagnosis to Treatment

Clerc, Christian; Miséry, Laurent

doi:10.2340/00015555-2574

Cited by 42 publications

(37 citation statements)

References 55 publications

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“…In this study, senile pruritus patients had significantly higher TEWL values than control subjects (13.13 ± 4.28 versus 6.71 ± 2.45, p < 0.01; Table 3). These results suggest that senile pruritus is associated with dysfunction of the skin barrier, consistent with the symptom of xerosis commonly observed in senile pruritus [5].…”

Section: Skin Barrier Functionsupporting

confidence: 82%

Lipidomics profiling of skin surface lipids in senile pruritus

Liu

Zhao

et al. 2020

Lipids Health Dis

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Background: Senile pruritus is common, yet its etiology remains unknown. Aging-associated skin barrier defects and skin surface lipid (SSL) alterations have been postulated to play important roles in its occurrence. In the present study, the lipidomic profiles of SSLs in elderly patients were examined to better understand the potential causes of senile pruritus. Methods: Transepidermal water loss (TEWL) was evaluated to assess the skin barrier function. The Ameliorated Kawashima Itch Scale score was used to measure the pruritus severity. Liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) and multivariate data analysis were employed to investigate SSL alterations. Results: The results showed that senile pruritus patients had higher TEWL values than control subjects (13.13 ± 4.28 versus 6.71 ± 2.45, p < 0.01). LC-MS/MS revealed significant differences in the lipidomic profiles and identified 81 species of SSLs that differed between the two groups. Compared with control subjects, senile pruritus patients had increased levels of ceramides (Cers), diacylglycerols, fatty acids, phosphatidylcholines, phosphatidylethanolamines, phytosphingosines, sphingosines, diacylceryl-3-O-carboxyhydroxymethylcholine, diacylglyceryl trimethylhomoserine, and unsaturated free fatty acids, but decreased levels of triacylglycerol. Cer-EOS, Cer-NDS, and Cer-NS were positively correlated with TEWL value (p < 0.05). Pruritus severity score was positively correlated with sphingomyelin, Cer-NP, Cer-AS, Cer-NDS, and Cer-NS, but negatively correlated with Cer-BS, Cer-EODS, Cer-EOS, and Cer-AP. Conclusions: The present study indicated that patients with senile pruritus have impaired skin barrier function and altered SSL composition. Certain SSL species identified in this study may be potential targets for future studies on the pathogenesis of senile pruritus.

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Section: Skin Barrier Functionsupporting

confidence: 82%

Lipidomics profiling of skin surface lipids in senile pruritus

Liu

Zhao

et al. 2020

Lipids Health Dis

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show abstract

“…In this study, senile pruritus patients had signi cantly higher TEWL values than control subjects (13.13±4.28 versus 6.71±2.45, p<0.01; Table 3). These results suggest that senile pruritus is associated with dysfunction of the skin barrier, consistent with the symptom of xerosis commonly observed in senile pruritus (5).…”

Section: Skin Barrier Functionsupporting

confidence: 82%

Lipidomics Profiling of Skin Surface Lipids in Senile Pruritus

Liu

Zhao

et al. 2020

Preprint

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Abstract Background: Senile pruritus is common, yet its etiology remains unknown. Aging-associated skin barrier defects and skin surface lipid (SSL) alterations have been postulated to play important roles in its occurrence. In the present study, the lipidomic profiles of SSLs in elderly patients were examined to better understand the potential causes of senile pruritus. Methods: Transepidermal water loss (TEWL) was evaluated to assess the skin barrier function. The Ameliorated Kawashima Itch Scale score was used to measure the pruritus severity. Liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) and multivariate data analysis were employed to investigate SSL alterations. Results: The results showed that senile pruritus patients had higher TEWL values than control subjects (13.13±4.28 versus 6.71±2.45, p<0.01). LC-MS/MS revealed significant differences in the lipidomic profiles and identified 81 species of SSLs that differed between the two groups. Compared with control subjects, senile pruritus patients had increased levels of ceramides (Cers), diacylglycerols, fatty acids, phosphatidylcholines, phosphatidylethanolamines, phytosphingosines, sphingosines, diacylceryl-3-O-carboxyhydroxymethylcholine, diacylglyceryl trimethylhomoserine, and unsaturated free fatty acids, but decreased levels of triacylglycerol. Cer-EOS, Cer-NDS, and Cer-NS were positively correlated with TEWL value (p<0.05). Pruritus severity score was positively correlated with sphingomyelin, Cer-NP, Cer-AS, Cer-NDS, and Cer-NS, but negatively correlated with Cer-BS, Cer-EODS, Cer-EOS, and Cer-AP. Conclusions: The present study indicated that patients with senile pruritus have impaired skin barrier function and altered SSL composition. Certain SSL species identified in this study may be potential targets for future studies on the pathogenesis of senile pruritus.Trial registration: Peking University International Hospital (Number: YN2018QN04; date: January 2019).

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“…Although univariate analysis showed that there was no significant association between patients with and without UDOP, and xerosis, the contribution of xerosis to pruritus should not be overlooked in patients especially with chronic pruritus in the presence of SSLs. While pruritus is a common symptom in the elderly population, xerosis is the most frequent dermatological change leading to pruritus in this group (17).…”

Section: Discussionmentioning

confidence: 99%

Factors Affecting the Etiology of Intractable Pruritus in Hospitalized Patients Without Primary Skin Lesions

Akdoğan¹,

Uysal²,

Öktem³

et al. 2019

Istanbul Med J

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Amaç: Kaşıntı sık görülen bir belirti olup dermatolojik, sistemik, nörolojik, psikojenik, mikst ve bilinmeyen sebepleri vardır. Bu çalışmanın amacı sekonder deri lezyonları (SDL) ile prezente olan, dirençli kaşıntı nedeniyle hastanede yatan hastalarda kaşıntı etiyolojisini (KET) bulmak ve KET'i etkileyen faktörleri değerlendirmektedir. Yöntemler: Retrospektif olarak SDL olan 95 hasta (erkek/ kadın: 47/48) çalışmaya alındı. Demografik ve klinik özellikler, tanısal işlemler ve tedavi ajanları kaydedildi. KET dermatolojik ve dermatoloji dışı sebepler olarak tanımlandı. Bulgular: Çalışmamızda ortalama (aralık) yaş 61 (11-91) yıl ve hastalık süresi 2 (0,06-120) aydı. Kaşıntı %78 hastada dermatolojik, %22 hastada dermatoloji dışı sebeplerle ilişkili bulundu. Tek değişkenli analiz yaş, ortalama hastalık süresi, akut veya kronik seyir, 3 aydan uzun süre sürekli ilaç kullanımı, kaşıntıya yol açabilecek ilaç kullanımı, eşlik eden sistemik hastalık, polifarmasi, böbrek fonksiyon testleri ve uyku bozukluğu varlığı ile altta yatan dermatolojik sebebe bağlı kaşıntısı (DSK) olan ve olmayan hastalarda ilişki gösterdi (sırasıyla p=0,

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A Literature Review of Senile Pruritus: From Diagnosis to Treatment

Cited by 42 publications

References 55 publications

Lipidomics profiling of skin surface lipids in senile pruritus

Lipidomics profiling of skin surface lipids in senile pruritus

Lipidomics Profiling of Skin Surface Lipids in Senile Pruritus

Factors Affecting the Etiology of Intractable Pruritus in Hospitalized Patients Without Primary Skin Lesions

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