A literature review on traditional herbal medicines for malaria

Noronha, Monica; Pawar, V A; Prajapati, Anil S.; Subramanian, R. B.

doi:10.1016/j.sajb.2019.11.017

Cited by 35 publications

(20 citation statements)

References 142 publications

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“…Approximately 25% of currently prescribed drugs are obtained from plants, and >11% of essential drugs are obtained from plants or synthetic drugs obtained from natural precursors. 17 Globally, >1,000 plant species have been reported to be used for the treatment of malaria traditionally, and thus are potential sources of new antimalarial drugs. 18 The root of Dorstenia barnimiana, known locally as "werk bemieda", is an erect perennial herb, and one of the most frequently used plants for medicinal purposes.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Antimalarial Activity of 80% Methanolic Root Extract of Dorstenia barnimiana Against Plasmodium berghei–Infected Mice

Derebe¹,

Wubetu²,

Alamirew³

2021

CPAA

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Background: Due to resistance of parasites, costs, and safety issues with currently available drugs, there is a need to discover new antimalarials. Medicinal plants are one of the most important sources of new drugs. The purpose of this study was to evaluate the antimalarial activity of a methanolic root extract of Dorstenia barnimiana in Swiss albino mice infected with Plasmodium berghei. Methods: Four-day suppressive, curative, and prophylactic tests were performed on mice infected with P. berghei to evaluate the antimalarial activity of a methanolic root extract of the plant. Parasitemia suppression, survival time, body-weight change, rectal temperature change, and packed-cell volume were used to evaluate the activity of the extract. Data were analyzed using one-way ANOVA followed by Tukey's post hoc test for comparisons between and within groups, with P<0.05 considered statistically significant. Results: The D. barnimiana root extract showed significant (P<0.01) parasitemia-suppressive activities in all models compared to the negative control. The extract increased mean survival time and prevented weight loss, reduction in temperature, and anemia significantly in all tested doses in 4-day suppressive and curative tests. Conclusion:Based on these findings, D. barnimiana root has promising antimalarial activity and can considered a potential source to develop new agents.

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Section: Introductionmentioning

confidence: 99%

“…Approximately 25% of currently prescribed drugs are obtained from plants, and >11% of essential drugs are obtained from plants or synthetic drugs obtained from natural precursors. 17 …”

Section: Introductionmentioning

confidence: 99%

Evaluation of Antimalarial Activity of 80% Methanolic Root Extract of Dorstenia barnimiana Against Plasmodium berghei–Infected Mice

Derebe¹,

Wubetu²,

Alamirew³

2021

CPAA

View full text Add to dashboard Cite

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“…Polycyclic endoperoxides are a rare group of naturally occurring metabolites found in various parts of plants such as leaves, roots, bark, stems, seeds, fruits, and flowers [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ]. In addition, they have been found in extracts of various types of marine invertebrates and algae, and endoperoxides are synthesized by various types of fungi, fungal endophytes, and other microorganisms [ 8 , 9 , 13 , 14 , 15 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Antiprotozoal and Antitumor Activity of Natural Polycyclic Endoperoxides: Origin, Structures and Biological Activity

et al. 2021

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Polycyclic endoperoxides are rare natural metabolites found and isolated in plants, fungi, and marine invertebrates. The purpose of this review is a comparative analysis of the pharmacological potential of these natural products. According to PASS (Prediction of Activity Spectra for Substances) estimates, they are more likely to exhibit antiprotozoal and antitumor properties. Some of them are now widely used in clinical medicine. All polycyclic endoperoxides presented in this article demonstrate antiprotozoal activity and can be divided into three groups. The third group includes endoperoxides, which show weak antiprotozoal activity with a reliability of up to 70%, and this group includes only 1.1% of metabolites. The second group includes the largest number of endoperoxides, which are 65% and show average antiprotozoal activity with a confidence level of 70 to 90%. Lastly, the third group includes endoperoxides, which are 33.9% and show strong antiprotozoal activity with a confidence level of 90 to 99.6%. Interestingly, artemisinin and its analogs show strong antiprotozoal activity with 79 to 99.6% confidence against obligate intracellular parasites which belong to the genera Plasmodium, Toxoplasma, Leishmania, and Coccidia. In addition to antiprotozoal activities, polycyclic endoperoxides show antitumor activity in the proportion: 4.6% show weak activity with a reliability of up to 70%, 65.6% show an average activity with a reliability of 70 to 90%, and 29.8% show strong activity with a reliability of 90 to 98.3%. It should also be noted that some polycyclic endoperoxides, in addition to antiprotozoal and antitumor properties, show other strong activities with a confidence level of 90 to 97%. These include antifungal activity against the genera Aspergillus, Candida, and Cryptococcus, as well as anti-inflammatory activity. This review provides insights on further utilization of polycyclic endoperoxides by medicinal chemists, pharmacologists, and the pharmaceutical industry.

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“…In addition to increases in morbidity and mortality, drug resistance has resulted in increased associated costs due to the ongoing efforts to improve the efficacy of antimalarial treatments, which indicates an urgent need for the discovery and development of new antimalarial agents. Medicinal food approaches are clearly feasible and have been beneficial with respect to drug discovery for malaria [ 15 ]. As such, we evaluated the antimalarial activity of an extract from the young stem of Ranunculus japonicus (RJE) and the parameters indicating physiopathological changes induced by P. berghei and RJE treatment to reveal the status of infection and therapeutic efficacy of RJE.…”

Section: Introductionmentioning

confidence: 99%

Antimalarial Effect of the Total Glycosides of the Medicinal Plant, Ranunculus japonicus

et al. 2021

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In traditional Chinese medicine, Ranunculus japonicus has been used to treat various diseases, including malaria, and the young stem of R. japonicus is consumed as a food in the Republic of Korea. However, experimental evidence of the antimalarial effect of R. japonicus has not been evaluated. Therefore, the antimalarial activity of the extract of the young stem of R. japonicus was evaluated in vitro using both chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) strains; in vivo activity was evaluated in Plasmodium berghei-infected mice via oral administration followed by a four-day suppressive test focused on biochemical and hematological parameters. Exposure to extracts of R. japonicus resulted in significant inhibition of both chloroquine-sensitive (3D7) and resistant (Dd2) strains of P. falciparum, with IC50 values of 6.29 ± 2.78 and 5.36 ± 4.93 μg/mL, respectively. Administration of R. japonicus also resulted in potent antimalarial activity against P. berghei in infected mice with no associated toxicity; treatment also resulted in improved hepatic, renal, and hematologic parameters. These results demonstrate the antimalarial effects of R. japonicus both in vitro and in vivo with no apparent toxicity.

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A literature review on traditional herbal medicines for malaria

Cited by 35 publications

References 142 publications

Evaluation of Antimalarial Activity of 80% Methanolic Root Extract of Dorstenia barnimiana Against Plasmodium berghei–Infected Mice

Evaluation of Antimalarial Activity of 80% Methanolic Root Extract of Dorstenia barnimiana Against Plasmodium berghei–Infected Mice

Antiprotozoal and Antitumor Activity of Natural Polycyclic Endoperoxides: Origin, Structures and Biological Activity

Antimalarial Effect of the Total Glycosides of the Medicinal Plant, Ranunculus japonicus

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