2023
DOI: 10.1002/1873-3468.14724
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A logical model of Ewing sarcoma cell epithelial‐to‐mesenchymal transition supports the existence of hybrid cellular phenotypes

Daner A. Silveira,
Shantanu Gupta,
Mariane da Cunha Jaeger
et al.

Abstract: Ewing sarcoma (ES) is a highly aggressive pediatric tumor driven by the RNA‐binding protein EWS (EWS)/friend leukemia integration 1 transcription factor (FLI1) chimeric transcription factor, which is involved in epithelial–mesenchymal transition (EMT). EMT stabilizes a hybrid cell state, boosting metastatic potential and drug resistance. Nevertheless, the mechanisms underlying the maintenance of this hybrid phenotype in ES remain elusive. Our study proposes a logical EMT model for ES, highlighting zinc finger … Show more

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