A Logistic Regression Model to Predict Nodal Malignancy among Cases With Lymphadenopathy

Abstract

Background: Peripheral lymphadenopathy can be caused by benign and malignant diseases. In this logistic regression model, we attempted to identify the clinical findings predicting high probability of nodal malignancy. Materials and Methods: Two hundred and twenty cases diagnosed by peripheral lymph node biopsy were studied. Of these, 164 had benign lymph node pathology, while the other 56 were malignant. The patients' medical charts were reviewed and a logistic regression model used to identify physical signs and simple investigations that will predict nodal malignancy. Results: Hard lymph node consistency, negative Mantoux test and positive abdominal ultrasound (showing hepatosplenomegaly with or without lymphadenopathy) were found to correlate with a higher probability of nodal malignancy. Conclusion: A logistic regression model is proposed to calculate the probability of lymph node malignancy at different ages and both sexes in relation to lymph node consistency, Mantoux test and abdominal ultrasound results.

The analysis of pathological findings for cervical lymph node biopsies in eastern Saudi Arabia

“…In developed regions such as Australia, Europe, and North America, granulomatous lymphadenitis is usually caused by a mycobacterium other than tuberculosis [15][16][17]. Consistent with previous studies from Saudi Arabia, Hodgkin's disease accounted for 8.7% of all lymphadenopathies in our study [3,11,18]. However, one study from a tertiary referral center found that Hodgkin's disease was observed in approximately 33% of cases, a figure that is much higher than previously reported [4].…”

“…In another study, 30% of lymph nodes exhibited non-specific reactive changes, and granulomatous conditions accounted for 28% of the cases [10]. In a third study, granulomatous lymphadenitis was the most common cause (43%) Amr [10] Sohaibani [11] Malik [18] Moore [9] Oquz [12] Current Country/city identified [3]. In the current study, the most common histopathological cause of lymphadenopathy was reactive disease (52.2%), followed by granulomatous disease (15.5%).…”

Biopsia de ganglio linfático: consideraciones básicas

“…En la práctica médica general, los procesos neoplásicos de los ganglios son poco frecuentes, representando alrededor del 1% de las biopsias, mientras que en los centros de referencia su incidencia puede llegar a ser hasta del 60% (1) . La edad es probablemente el factor más importante para predecir si el origen de la linfadenopatía es benigna o maligna (4,5,6) . En pacientes arriba de los 50 años existe mayor posibilidad de procesos malignos, mientras que en los pacientes jóvenes menores de 30 años es más probable una patología infecciosa o reacciones hiperplásicas indeterminadas (2,5) .…”