A long non-coding RNA targets microRNA miR-34a to regulate colon cancer stem cell asymmetric division

Wang, Lihua; Bu, Pengcheng; Ai, Yiwei; Srinivasan, Tara; Chen, Huanhuan Joyce; Xiang, Kun; Lipkin, Steven M.; Shen, Xiling

doi:10.7554/elife.14620

Cited by 97 publications

(93 citation statements)

References 51 publications

(59 reference statements)

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“…Hence, lncRNAs may play an important role in tumorigenesis and tumour progression [23]. Numerous studies have confirmed that lncRNAs are involved in the tumorigenesis and development of CRC via multiple pathways, such as DNA methylation and histone modifications [24, 25]. These findings have posed the question of how to accurately screen for lncRNAs of interest within the vast amount of data already available.…”

Section: Discussionmentioning

confidence: 99%

Mining, Validation, and Clinical Significance of Colorectal Cancer (CRC)-Associated lncRNAs

Sun

Liang

et al. 2016

PLoS ONE

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BackgroundColorectal cancer (CRC) is one of the deadliest tumours, but its pathogenesis remains unclear. The involvement of differentially expressed long non-coding RNAs (lncRNAs) in CRC tumorigenesis makes them suitable tumour biomarkers.Methods/FindingsHere, we screened 150 cases of CRC and 85 cases of paracancerous tissues in the GEO database for differentially expressed lncRNAs. The levels of lncRNA candidates in 84 CRC and paracancerous tissue samples were validated by qRT-PCR and their clinical significance was analyzed. We identified 15 lncRNAs with differential expression in CRC tumours; among them, AK098081 was significantly up-regulated, whereas AK025209, BC040303, BC037331, AK026659, and CR749831 were down-regulated in CRC. In a receiver operating characteristic curve analysis, the area under the curve for the six lncRNAs was 0.914. High expression of AK098081 and low expression of BC040303, CR749831, and BC037331 indicated poor CRC differentiation. CRC patients with lymph node metastasis had lower expression of BC037331. In addition, the group with high AK098081 expression presented significantly lower overall survival and disease-free survival rates than the low-expression group, confirming AK098081 as an independent risk factor for CRC patients.Conclusion/SignificanceIn conclusion, we have identified multiple CRC-associated lncRNAs from microarray expression profiles that can serve as novel biomarkers for the diagnosis and prognosis of CRC.

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Section: Discussionmentioning

confidence: 99%

Mining, Validation, and Clinical Significance of Colorectal Cancer (CRC)-Associated lncRNAs

Sun

Liang

et al. 2016

PLoS ONE

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“…lncRNA34a recruits DNMT3a to establish de novo DNA methylation, and histone deacetylase 1 (HDAC1) to deacetylate and methylate the miRNA34a promoter, in a manner reminiscent of protein‐mediated DNA methylation. Ultimately, this process regulates asymmetric colorectal cancer stem cell division . Another miRNA, miRNA‐146a , targets NUMB to stabilize β‐CATENIN, controlling cell division of colorectal cancer stem cells .…”

Section: Epigenetic Regulation Of Crypt Cell Maintenance and Differenmentioning

confidence: 99%

Signaling and epigenetic mechanisms of intestinal stem cells and progenitors: insight into crypt homeostasis, plasticity, and niches

Smith

Rao-Bhatia

Kim

2017

WIREs Developmental Biology

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The rapid turnover of intestinal epithelial cells is maintained by a small number of stem cells located in pocket-like gland structures called crypts. While our understanding of the identity and function of intestinal stem cells (ISCs) has rapidly progressed, epigenetic and transcriptional regulation in crypt stem cell and progenitor pools remains an active field of investigation. Surrounded by various types of cells in the stroma, crypt progenitors display high levels of plasticity, harboring the ability to interconvert in the face of epithelial damage. Recent studies analyzing epigenetic patterns of intestinal epithelial cells have provided evidence that plasticity is maintained by a broadly permissive epigenomic state, wherein cell-lineage specification is directed through activation of signaling pathways and transcription factor (TF) expression. New studies also have shown that the ISC niche, which is comprised of surrounding epithelial and mesenchymal tissues, plays a crucial role in supporting the maintenance and differentiation of stem cells by providing contextual information in the form of signaling cascades, such as Wnt, Notch, and Hippo. These cascades ultimately govern TF expression to promote early cell-lineage decisions in both crypt stem cells and progenitors. Highlighting recent studies investigating signaling, transcriptional, and epigenetic mechanisms of intestinal epithelial cells, we will discuss the mechanisms underlying crypt homeostasis, plasticity, and niches. WIREs Dev Biol 2017, 6:e281. doi: 10.1002/wdev.281 For further resources related to this article, please visit the WIREs website.

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“…The results of clinical features showed that TUSC7 was associated with tumor size, HOTAIR with tumor size and TNM-stage. In table 1, we concluded a correlation with CRC clinical features and lncRNAs for visually understanding that lncRNAs might be as markers for CRC diagnosis (Table 1) [16, 17, 47, 57, 75-80]. Sun et al reported that ANRIL could enhance cell mobility and invasion by in-vitro tube formation HLECs invasion.…”

Section: Clinical Significance Of Lncrnas For Crcmentioning

confidence: 99%

“…Recently, Lihua et al found a novel lncRNAs, lnc34a, was notably upregulated in colon cancer stem cell (CCSC) lines and promoted CCSC self-renewing and tumorigenesis. Moreover, lnc34a recruit Dnmt3a via PHB2 and HDAC1 to target miR-34a by methylating and deacetylatingits promoter to promote CRC cell proliferation [47]. Upregulated GAS5 reduced ability of cell proliferation, and promoted G0/G1 cell cycle arrest and apoptosis [48].…”

Section: The Role Of Lncrnas In Crcmentioning

confidence: 99%

The Biological Effect and Clinical Application of Long Noncoding RNAs in Colorectal Cancer

Sun¹,

Wang²,

Chen³

et al. 2018

Cell Physiol Biochem

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Colorectal cancer (CRC) is one of the most common malignancies in the world. Easier recurrence and metastasis is the main cause of mortality in CRC patients, and the markers applied for diagnosis and treatment of CRC is still urgently needed to early diagnose and evaluate therapeutic effect. Long noncoding RNA (lncRNA) is a class of noncoding RNA that the length is more than 200 nucleotides. With the development of sequencing technique about transcriptome, increasing lncRNAs are focused on their function and mechanism related to the nosogenesis and pathology of CRC. Recent studies report that lncRNAs acted as crucial role in CRC and could be as biomarker for CRC diagnosis and treatment. In this review, we display the regulation of lncRNA by interacting with DNA, RNA and protein and highlight the double role of lncRNAs as oncogene or anti-tumor gene involved in Wnt signaling pathway, p53 signaling pathway or others to be an regulator in CRC development. Lastly, we discuss some new finding of lncRNAs, especially lncRNA in exosome, which could be as potential markers for diagnosis and treatment of CRC in future.

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A long non-coding RNA targets microRNA miR-34a to regulate colon cancer stem cell asymmetric division

Cited by 97 publications

References 51 publications

Mining, Validation, and Clinical Significance of Colorectal Cancer (CRC)-Associated lncRNAs

Mining, Validation, and Clinical Significance of Colorectal Cancer (CRC)-Associated lncRNAs

Signaling and epigenetic mechanisms of intestinal stem cells and progenitors: insight into crypt homeostasis, plasticity, and niches

The Biological Effect and Clinical Application of Long Noncoding RNAs in Colorectal Cancer

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