A long-term comparison of protein turnover in subcrestal vs supracrestal fibre tracts in the mouse periodontium

Minkoff, Robert; Engstrom, T.G.

doi:10.1016/0003-9969(79)90044-x

Cited by 17 publications

(14 citation statements)

References 21 publications

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“…1976]. In the present study, the first peak in grain incorporation occurred at approximately 6 h. con firming the reports of Minkoff and Engstrom [1979] and Minkoff et al [1981]. However, they did not report a second peak at 2 (mesial third) and 4 (distal third) days or a plateau from 3 to 4 days (middle third) as described herein.…”

Section: Discussionsupporting

confidence: 66%

“…Skougaard et al (1970a. b], Kameyama [1975] and Minkoff and Engstrom [1979], in radioautographic studies, suggest that the rate of collagen turnover is slower in the transseptal than in the periodon tal ligament. Conversely.…”

Section: Introductionmentioning

confidence: 99%

“…These studies suggest regional variations in degradation of collagen in gingiva, but do not specifi cally (1) identify locations of regional variation or (2) describe the transseptal ligament. Minkoff and Engstrom [1979] and Minkoff et al [ 1981] suggest uniform collagen ous remodeling rates in the transseptal ligament. Regional variability in collagenous protein remodeling of the perio dontal ligament is controversial [Beertsen.…”

Section: Introductionmentioning

confidence: 99%

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A Reevaluation of the Distribution of <sup>3</sup>H-Proline in the Transseptal Ligament of the Mouse in Radioautography

Johnson¹

1989

Cells Tissues Organs

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It is generally accepted that there is uniform collagen metabolism within the periodontal and transseptal ligaments. The present study suggested regional variations in the incorporation and removal of ³H-proline within the transseptal ligament in radioautography, suggesting variable rates of collagenous protein remodeling coincident with physiological tooth movements. Highest numbers of silver grains were over the middle third of the ligament during both incorporation and removal phases (p < 0.001). Rates of grain removal were greater in the middle than in mesial or distal thirds (p < 0.001). The half-life of labeled proteins was significantly less in the middle than in mesial or distal thirds (p < 0.005). Because there were no significant regional differences in cell numbers, regional variability in grain incorporation and removal within the transseptal ligament likely indicates regional differences in cellular synthetic or degradative activity coincident with remodeling of the transseptal ligament during physiological drift and suggests that the center of this ligament may experience more stress and, thus, remodels more rapidly.

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Section: Discussionsupporting

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Reevaluation of the Distribution of <sup>3</sup>H-Proline in the Transseptal Ligament of the Mouse in Radioautography

Johnson¹

1989

Cells Tissues Organs

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“…Minkoff and Engstrom 23 and Rippin 24 stated that fibroblast activity is lower in dentogingival regions than in dentoalveolar regions. However, Deporter et al 25 and Proye and Polson 26 have suggested that collagen turnover in the transseptal region is at least as high as, and possibly higher than, that in the periodontal ligament.…”

Section: Discussionmentioning

confidence: 99%

Laser-Aided Circumferential Supracrestal Fiberotomy and Low-Level Laser Therapy Effects on Relapse of Rotated Teeth in Beagles

Kim

Paek²,

Park

et al. 2010

The Angle Orthodontist

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Objective: To investigate the effectiveness and periodontal side effects of laser circumferential supracrestal fiberotomy (CSF) and low-level laser therapy (LLLT) on orthodontically rotated teeth in beagles. Materials and Methods: Eighteen mandibular incisors from nine dogs were divided into three groups by treatment (n 5 6/group): A, orthodontic couple force application only (control); B, laser CSF following orthodontic couple force application; and C, LLLT following orthodontic couple force application. Both mandibular lateral incisors were rotated for 4 weeks, and the relapse tendency was observed for 4 weeks more without any retainers. The amount of relapse, sulcus depth, and gingival recession were measured at weeks 4 and 8. One-way analysis of variance (ANOVA) and Scheffé 's post hoc test were used for data analysis. Tissue specimens were examined at week 8 under light microscopy after hematoxylin-eosin (H&E) and Masson's trichrome staining. Results: The mean percentage of relapse was 41.29% in group A, 14.52% in group B, and 56.80% in group C (P , .001). Four weeks after laser CSF, the sulcus depth increased by 0.67 mm, but no gingival recession was observed. There was no significant difference between groups A and C in terms of sulcus depth and gingival recession. Conclusions: Laser CSF is an effective procedure to decrease relapse after tooth rotation, causing no apparent damage to the supporting periodontal structures, whereas LLLT on orthodontically rotated teeth without retainers appears to increase the relapse tendency. (Angle Orthod 2010;80:385-390.)

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“…Because lathyrism does not affect tropocollagen synthesis but disturbs the aggregation of newly formed molecules (Levene 1973), it was considered that tissues with a higher turnover of collagen were more susceptible to the effects of the disease. The periodontal ligament has a high turnover of collagen (Skougaard, Frandsen & Baker 1970, Kameyama 1975, and there is evidence that a rate differential exists along the length of the ligament (Rippin 1976, Minkoff & Engstrom 1979. Minkoff and Engstrom (1979) have radioautographically determined that the labelled protein halflives for the dentogingival (25 days) and transseptal fibres (8.4 days) are greater than other collagen fibres of the 40-day-old mouse periodontal hgament (5-7 days).…”

Section: Lathyrismmentioning

confidence: 99%

Effects of lathyrism on mouse molar migration

Dreyer

Sampson

1984

J of Periodontal Research

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Previous cursory reports of lathyritic aiveoiar bone activity prompted a histotogic and radioautographic investigation of tooth migration patterns in normal and lathyritic mice. Using Sharpey's fiber patterns and the distribution of (^H)-proUne radioactive label as indicators, bone deposition was found on distal, occlusal, and buccal facing alveolar surfaces and revealed normal tooth migration to be in a distal, occlusal, and buccal direction. In addition, the radioautographic label confirmed the reliability of using Sharpey's fiber patterns as directional indicators. Over a forty-day lathyritic period a progressive disturbance of Sharpey/principal fiber attachment at the bone surface plus radioautographic inactivity indicated that the distal and buccal vectors of migration had ceased. However, occlusal migration appeared to continue. These results were considered to be a likely consequence of the duration and severity of the iathyritic change and the difference in turnover times between the supracrestal and periodontai ligament collagen fibers, with further consideration to the occlusion, ultrastructural, and vasailar changes being required.

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A long-term comparison of protein turnover in subcrestal vs supracrestal fibre tracts in the mouse periodontium

Cited by 17 publications

References 21 publications

A Reevaluation of the Distribution of <sup>3</sup>H-Proline in the Transseptal Ligament of the Mouse in Radioautography

A Reevaluation of the Distribution of <sup>3</sup>H-Proline in the Transseptal Ligament of the Mouse in Radioautography

Laser-Aided Circumferential Supracrestal Fiberotomy and Low-Level Laser Therapy Effects on Relapse of Rotated Teeth in Beagles

Effects of lathyrism on mouse molar migration

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