A long-term follow-up study of nasal polyp patients after simple polypectomies

Larsen, Knud; Tos, Mirko

doi:10.1007/bf02439732

Cited by 55 publications

(53 citation statements)

References 16 publications

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“…When performed alone, simple polypectomy carries a very high recurrence rate, reportedly as high as 75 % in an 8-year follow-up study [28]. New techniques to allow in-office simple polypectomy, thus reducing costs in service delivery, have been suggested to offer a cost-effective alternative to ESS, despite higher recurrence rates [29].…”

Section: Nasal Polypectomy Alone Versus Adjunctive Endoscopic Sinus Smentioning

confidence: 98%

Surgical Versus Medical Interventions in CRS and Nasal Polyps: Comparative Evidence Between Medical and Surgical Efficacy

Dessouky

Hopkins

2015

Curr Allergy Asthma Rep

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CRS with nasal polyps (CRSwNP) is a subgroup of CRS, where polyps can be visualised in the middle meatus. In the general population, the prevalence is estimated to lie between 0.2 and 4 %. Up to 15 % of patients with asthma have nasal polyps and up to 45 % of patients with nasal polyps have asthma. The management of CRSwNP involves primary medical management, with surgery normally reserved for recalcitrant cases. Surgical techniques for CRSwNP range from simple polypectomy and endoscopic sinus surgery (ESS) to radical nasalisation with removal of the middle turbinates. We have reviewed the comparative literature regarding medical and surgical interventions in CRSwNP, with emphasis on outcomes, complications, cost-effectiveness and on the timing of surgery. Similar outcomes are reported for medical and surgical management, but there is sufficient evidence to support the role of surgery once symptoms have failed to adequately respond. There is insufficient evidence to define the optimal timing and extent of surgery.

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Section: Nasal Polypectomy Alone Versus Adjunctive Endoscopic Sinus Smentioning

confidence: 98%

Surgical Versus Medical Interventions in CRS and Nasal Polyps: Comparative Evidence Between Medical and Surgical Efficacy

Dessouky

Hopkins

2015

Curr Allergy Asthma Rep

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“…18). 38,39 In such cases, imaging is useful for assessing extent of disease and planning further surgery.…”

Section: Recurrent Rhinosinusitismentioning

confidence: 99%

Posttreatment Imaging of the Paranasal Sinuses Following Endoscopic Sinus Surgery

Ginat

2015

Neuroimaging Clinics of North America

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“…Nasal polyps occur more commonly in asthmatic patients, and asthma is associated with a higher rate of polyp recurrence after surgery [1,2,3,4,5]. Unfortunately, the effects of steroid treatment for recurrence after surgery are also often temporary [6,7,8].…”

Section: Introductionmentioning

confidence: 99%

Peroxisome Proliferator-Activated Receptor-γ Is Expressed in Eosinophils in Nasal Polyps

Asaka

Honda²,

Ito³

et al. 2011

Int Arch Allergy Immunol

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Background: Peroxisome proliferator-activated receptor-γ (PPARγ) is a member of the nuclear receptors, which regulate fatty acid metabolites. One of the natural ligands for PPARγ is 15-deoxy-Δ^12,14-prostaglandin J₂ (15d-PGJ₂), a major metabolite of prostaglandin D₂ (PGD₂). Recently, PPARγ has been shown to play an important role in anti-inflammatory reactions, including within-airway allergic diseases, in a mouse model. Our aim was to clarify the expression and localization of PPARγ and PGD₂ synthase, which produces ligands of PPARγ, in nasal polyps by immunohistochemical analysis. Methods: Nasal polyps of chronic rhinosinusitis patients (6 asthmatic patients and 6 nonasthmatic patients) were obtained during surgery. May-Grünwald-Giemsa staining was performed to evaluate the eosinophil infiltration of the polyps. To identify the cells expressing PPARγ protein and PGD₂ synthase, double immunostaining was performed using anti-PPARγ antibody, monoclonal antileukocyte antibodies, and PGD₂ synthase antibody. Results: The number of eosinophils and the number of PPARγ-positive cells in the nasal polyps of the asthmatic patients were significantly higher than those in the nonasthmatic patients. PPARγ was expressed on eosinophils and T cells of the infiltrating cells in the nasal polyps. PGD₂ synthase was also expressed on PPARγ-positive cells. Conclusion: PPARγ is involved in nasal polyposis pathogenesis, acting on eosinophils and T cells.

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A long-term follow-up study of nasal polyp patients after simple polypectomies

Cited by 55 publications

References 16 publications

Surgical Versus Medical Interventions in CRS and Nasal Polyps: Comparative Evidence Between Medical and Surgical Efficacy

Surgical Versus Medical Interventions in CRS and Nasal Polyps: Comparative Evidence Between Medical and Surgical Efficacy

Posttreatment Imaging of the Paranasal Sinuses Following Endoscopic Sinus Surgery

Peroxisome Proliferator-Activated Receptor-γ Is Expressed in Eosinophils in Nasal Polyps

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