A long-term survey of brucellosis: Is there any marker to predict the complicated cases?

Kayaaslan, Bircan; Baştuğ, Aliye; Aydin, Emsal; Akıncı, Esragül; But, Ayşe; Aslaner, Hümeyra; Yetkin, Meltem Arzu; Bodur, Hürrem

doi:10.3109/23744235.2015.1107187

Cited by 19 publications

(38 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, there is no consensus in the literature regarding the optimal treatment approach for complicated cases. In a study carried out by Kayaaslan et al [8] , treatment duration for brucellosis patients with osteoarticular involvement ranged between four and six months. In a study by Kaptan et al [19] , patients with Brucella spondylodiscitis underwent treatment for 12-39 weeks.…”

Section: Discussionmentioning

confidence: 99%

“…Although complications vary in frequency, site of involvement, and presentation, osteoarticular complications are reported to be the most common type of complication in patients with brucellosis [8,14,27] . In a systematic review evaluating Brucellosis patients in Turkey, Calik and Gokengin [1] reported the rate of osteoarticular complications to be 43.74% (n=1839).…”

Section: Discussionmentioning

confidence: 99%

“…In a systematic review evaluating Brucellosis patients in Turkey, Calik and Gokengin [1] reported the rate of osteoarticular complications to be 43.74% (n=1839). Kayaaslan et al [8] determined the rate of osteoarticular complications as 22% in a study including 700 patients. At a rate of 19.8%, osteoarticular complications were also the most common in our study.…”

Section: Discussionmentioning

confidence: 99%

“…Osteoarticular complication: Defined as the detection of inflammation in one or more vertebrae (±discs) or in the joint region by radiological or/and scintigraphic methods [4,8] .…”

Section: Complicationmentioning

confidence: 99%

“…Relapse: Inpatients diagnosed with and treated for brucellosis, relapse was defined as the recurrence of symptoms and signs associated with brucellosis and at least one of the following findings at least six months after termination of treatment [2,8] :…”

Section: Cardiac Complicationmentioning

confidence: 99%

See 4 more Smart Citations

Osteoarticular Involvement and Inadequate Treatment of Brucellosis Are Related with Relapse

Özger¹,

Karaşahin²,

Yıldız³

et al. 2020

mjima

View full text Add to dashboard Cite

The goal of treatment in brucellosis is to control symptoms to prevent the development of complications and relapse of infection. The aim of this study was to evaluate the risk factors for relapse in brucellosis patients, including those with complications. Materials and Methods: Our study was performed retrospectively with data from three centers. Complication of brucellosis was defined as the involvement of specific anatomical regions in the disease. Recurrence of symptoms and signs of brucellosis six months after termination of treatment and increased standard tube agglutination titer under treatment or isolation of Brucella spp. in sterile body fluids was defined as relapse. Inadequate treatment duration was defined as a treatment duration of less than eight weeks in patients with osteoarticular complications and less than six weeks in other brucellosis involvement. A multivariate logistic regression model was built with the variables determined to be effective in relapse development. The logistic regression model included gender, the presence of osteoarticular complications, inadequate treatment duration, treatment combinations, and leukocyte count. The SPSS 20 statistical package program was used for statistical analysis. Results: A total of 1,296 patients were enrolled in the study. Their median age was 42 (31-54) years and 631 (48.7%) were female. One or more complications were detected in 448 (34.6%) cases. A two-drug antibiotic combination was given to 1,125 (86.8%) patients and 171 (13.2%) were treated with a three-drug antibiotic combination regimen. Three hundred sixteen (24.4%) of the patients were treated with combination therapies that included an aminoglycoside. Relapse occurred in 110 (8.5%) patients, and treatment was inadequate for 105 (8.1%) cases. Osteoarticular complications were more frequent in patients with relapse than in those without relapse (33.6% vs 18.5%, p<0.001). The presence of osteoarticular complications [odds ratio (OR): 2.413, 95% confidence interval (CI): 1.550-3.756] and inadequate treatment duration (OR: 2.861, 95% CI: 1.645-4.974) were associated with a higher rate of brucellosis relapse, while combination therapies including an aminoglycoside (OR: 0.432, 95% CI: 0.249-0.752) was associated witha lower relapse rate. Conclusion: Our results indicate that in patients with osteoarticular complications, treatment should be administered for the recommended optimal duration, and combination therapies including aminoglycosides should be chosen preferentially in order to prevent a relapse of infection.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Osteoarticular complication: Defined as the detection of inflammation in one or more vertebrae (±discs) or in the joint region by radiological or/and scintigraphic methods [4,8] .…”

Section: Complicationmentioning

confidence: 99%

Section: Cardiac Complicationmentioning

confidence: 99%

See 3 more Smart Citations