A Long-Term Survival Case of Mucin-Producing Bile Duct Carcinoma Treated with Repetitive Surgical Procedure

Kurahara, Hiroshi; Shinchi, Hiroyuki; Mataki, Yuko; Maeda, Satoshi; Natsugoe, Shoji; Takao, Sonshin

doi:10.5833/jjgs.42.510

Cited by 7 publications

(3 citation statements)

References 6 publications

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“…Even if the bile duct resection stump is negative, attention should be paid to the level of atypia, and from the perspective of intraoperative implantation prevention from cancer cells in bile mucus, a care must be taken not to spill bile mucus. Literature examination in Japan showed that the recurrence of mucus-producing cholangiocarcinoma after a radical surgery exhibited cancerous peritonitis, 12 recurrence of PTCD fistula, 15 and report of recurrence in remaining bile duct, 16 and there are reports of what could be implantation or bile duct stump relapse. We examined a case of re-resection for IPNB case with high likelihood of relapse from remaining bile duct from resection 24 years ago, 17 but there still is no case of long-term survival after a surgery on solitary recurrence as in the present case.…”

Section: Discussionmentioning

confidence: 99%

Resection for a Recurrent Mucus-Producing Cholangiocarcinoma After Surgery: a Case Report

Yamada

Ajiki

Onoyama

et al. 2019

International Surgery

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Introduction Intraductal papillary neoplasm of the bile duct (IPNB) is a variant of bile duct carcinoma characterized by intraductal growth. There are few case reports and papers discussing treatment policy and prognosis for cases of postoperative relapse. Case Presentation The case subject was a female in her 40s. Due to IPNB with the primary tumor in hepatic left lobe, the patient underwent hepatic left lobe, caudate lobe, and bile duct resection, and biliary tract reconstruction at another institution. Four years later, near the cholangiojejunostomy, a localized recurrence was indicated. Though systemic metastasis was examined with CT, FDG-PET, distant metastasis was not confirmed. As it was believed that resection of the recurrent focal could lead to a long-term survival, the recurrent focal was resected. The resected specimen was a cystic mass with a film, and in a pathologic examination, lymph node tissue was not confirmed in the specimen, while intracystic papilloma of attached liver tissue without continuity was confirmed. The patient has not seen a relapse for 5 years and 5 months after the second surgery. Conclusion In a case of localized recurrence after the IPNB surgery, resection should be actively considered.

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Section: Discussionmentioning

confidence: 99%

Resection for a Recurrent Mucus-Producing Cholangiocarcinoma After Surgery: a Case Report

Yamada

Ajiki

Onoyama

et al. 2019

International Surgery

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“…Rocha et al [ 5 ] reported recurrence in 20 of 39 patients (51%) with IPNB, including 35% with locoregional, 35% with distant, and 30% with combined recurrence. Studies have suggested underlying mechanisms of recurrence in the remnant bile duct, such as multicentricity [ 1 , [6] , [7] , [8] ], persistence of atypical epithelium [ 5 , 7 ], and intrabiliary dissemination [ 8 , 9 ]. Although cases of IPNB recurrence in the remnant bile duct have previously been thought to represent multicentric recurrence, Yokode et al [ 9 ] described that true multicentric recurrence was less common than that considered initially.…”

Section: Discussionmentioning

confidence: 99%

Intraductal papillary neoplasm of the bile duct with rapidly progressive multicentric recurrence: A case report

Kageyama

Yamaguchi

Watanabe

et al. 2018

International Journal of Surgery Case Reports

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“…Although the majority of the patients had a single episode of tumor recurrence, 2 patients had multiple episodes (cases 3 and 7 in Table I ) ( 13 , 17 ). Miyata et al ( 17 ) described a case that developed recurrent IPNB twice.…”

Section: Discussionmentioning

confidence: 99%

Biliary intraductal papillary neoplasm with metachronous multiple tumors - true multicentric tumors or intrabiliary dissemination: A case report and review of the literature

Yokode

Yamashita

Zen

2017

Molecular and Clinical Oncology

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Intraductal papillary neoplasms of the bile duct (IPNBs) are recognized as a distinct type of biliary tumor. We herein discuss the possible mechanisms underlying the development of multiple tumors in patients with IPNBs through a case presentation and literature review. A 64-year-old woman initially underwent extended right hepatectomy for IPNB in the right hepatic duct. Although the surgical margin of the common bile duct was tumor-free, recurrence was detected in the intrapancreatic bile duct 26 months later. Both tumors had similar histopathological characteristics (intestinal-type IPNB with high-grade dysplasia, but no invasive cancer). A literature review identified 9 additional cases of multiple IPNBs. Unlike conventional IPNBs, which typically affect the intrahepatic or hilar bile duct, 80% of recurrent multiple tumors developed in the extrahepatic bile duct. Although multicentric tumors have been suggested in such cases, the intrabiliary dissemination of tumor cells appears to be more likely, as the majority of recurrent tumors develop in more distal parts of the bile duct compared with the primary tumor.

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A Long-Term Survival Case of Mucin-Producing Bile Duct Carcinoma Treated with Repetitive Surgical Procedure

Cited by 7 publications

References 6 publications

Resection for a Recurrent Mucus-Producing Cholangiocarcinoma After Surgery: a Case Report

Resection for a Recurrent Mucus-Producing Cholangiocarcinoma After Surgery: a Case Report

Intraductal papillary neoplasm of the bile duct with rapidly progressive multicentric recurrence: A case report

Biliary intraductal papillary neoplasm with metachronous multiple tumors - true multicentric tumors or intrabiliary dissemination: A case report and review of the literature

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