A long-term survivor of undifferentiated carcinoma of the liver successfully treated with surgical treatments: A case report and literature review

Hiraki, Masatsugu; Kono, Kenji; Miyoshi, Anderson; Koga, Hiroki; Nakamura, Hiroaki; Kubo, Hiroshi; Ikeda, Osamu; Yoshioka, Wataru; Nakashita, Shunya; Nishihara, Yunosuke; Akashi, Michiaki; Azama, Shinya; Kawaguchi, Yasunori; Mori, Daisuke; Aishima, Shinichi; Aibe, Hitoshi; Tanaka, Toshiya; Sato, Seiji

doi:10.1016/j.ijscr.2018.07.047

Cited by 7 publications

(4 citation statements)

References 14 publications

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“…Masatsugu et al. described radical surgery without any chemotherapy for an undifferentiated liver tumor that achieved good results ( 31 ). According to Hood et al., a woman with recurrent OCGT of the liver was treated with 5-fluorouracil and adriamycin, external beam radiation, and radioimmune therapy (IgG, labeled with I-131) ( 11 ).…”

Section: Discussionmentioning

confidence: 99%

Undifferentiated hepatic carcinoma with osteoclast-like giant cells: A case report and literature review

et al. 2023

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Osteoclast-like giant cell tumor (OGCT) is a common bone tumor, occasionally observed in some extraosseous organs, but rarely involving the digestive system, especially the liver. Previously reported osteoclast-like giant cell carcinoma of the liver often coexists with sarcomatoid or hepatocellular carcinoma. Undifferentiated liver tumors with osteoclast-like giant cells (OGCs) are extremely rare. Due to its rarity, there is no consensus for diagnosis and treatment of undifferentiated liver tumors with OGCs. Definitive diagnosis comes from surgery, so there is often a long delay in diagnosis following the occurrence of symptoms. This case describes an extremely rare case of an undifferentiated liver tumor with OGCs in detail. It also summarizes the previously published cases based on liver tumors with OGCs from August 1980 to June 2021, providing extensive evidence to improve preoperative diagnosis and management options.

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Section: Discussionmentioning

confidence: 99%

Undifferentiated hepatic carcinoma with osteoclast-like giant cells: A case report and literature review

et al. 2023

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“…While undifferentiated carcinoma of the liver lacks a definitive treatment protocol [1][2][3], nivolumab, an immuno-checkpoint inhibitor, has shown promise for those cases classified under the 'poor prognosis group' of cancers of unknown primary [10]. These elusive cancers are bifurcated clinically and pathologically into two main categories.…”

Section: Discussionmentioning

confidence: 99%

“…Undifferentiated carcinoma of the liver is a rare malignant neoplasm [ 1 , 2 ]. The clinicopathological features and progression of this carcinoma are not well-documented, and no definitive therapeutic approach exists for inoperable instances [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Autopsy-Confirmed Undifferentiated Carcinoma of the Liver With Rapid Bone Metastasis

Kobayashi,

Shibata,

Ohmoto

et al. 2023

Cureus

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A male in his late 70s, with progressive hip pain, was diagnosed with a metastatic iliac bone tumor, initially misinterpreted as septic arthritis. Despite extensive imaging, the primary tumor site was undetected until autopsy, which confirmed undifferentiated carcinoma of the liver with secondary lung involvement. The patient's poor performance status and rapid health decline precluded aggressive treatment, leading to his demise. This case underscores the difficulties in diagnosing such carcinomas and suggests that early identification and innovative therapies like nivolumab could potentially extend life in similar cases.

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“…Owing to the relative rarity of UCDS and the lack of clinical trials, therapeutic guidelines or recommendations are not available (31). Literature reports have suggested a variety of regional and systemic treatment strategies; however, complete response and long-time survival were achieved in only a few cases (32,33). Reis Neto et al studied 287 patients with rectal adenocarcinoma treated with radiotherapy followed by surgery and reported that preoperative radiotherapy decreased the proportion of undifferentiated cells, indicating that undifferentiated rectal cancer cells were more sensitive to the radiation than differentiated cancer cells (34).…”

Section: Discussionmentioning

confidence: 99%

Incidence and prognosis of undifferentiated cancers of the digestive system: a population-based cohort study

Qiu¹,

Yan

2021

Ann Transl Med

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Background: Cases of undifferentiated cancers of the digestive system (UCDS) are occasionally encountered in clinical practice; however, no large-scale studies have described their characteristics. This study aimed to investigate the incidence, prognosis, and treatment strategies of UCDS.Methods: We used the data from the Surveillance, Epidemiology, and End Results database to evaluate clinical characteristics in UCDS patients. A cohort of 1,372 patients was included to estimate UCDS incidence; another cohort of 1,816 patients was followed up until December 31, 2017 to evaluate treatment and prognosis. The incidence, trends, treatments, overall survival, and cause-specific survival were assessed.Results: The estimated incidence of UCDS was 0.136 per 100,000 people-years [95% confidence interval (CI): 0.129-0.143] from 1975 to 2016 with respect to sex, age, year of diagnosis, race, region, site, income, and education. The age-adjusted rates of UCDS dropped from 0.567 per 100,000 people-years in 1978 to 0.031 per 100,000 people-years in 2016. The rates of surgery, beam radiation, and chemotherapy in patients with UCDS were 37.3%, 17.3%, and 30.7%, respectively. Overall, the 5-year cause-specific survival rate was 18%, with a median cause-specific survival of 4 months. Patient prognosis improved significantly over the decades; stage, site, year of diagnosis, surgery, beam radiation, and chemotherapy were independent prognostic factors for UCDS mortality. Conclusions:The incidence of UCDS has decreased in the United States over the past 40 years.Patients benefited from surgery, beam radiation, and chemotherapy. The survival of patients with UCDS has improved. Further research on developing decision-making recommendations for UCDS treatment is crucial.

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A long-term survivor of undifferentiated carcinoma of the liver successfully treated with surgical treatments: A case report and literature review

Cited by 7 publications

References 14 publications

Undifferentiated hepatic carcinoma with osteoclast-like giant cells: A case report and literature review

Undifferentiated hepatic carcinoma with osteoclast-like giant cells: A case report and literature review

Autopsy-Confirmed Undifferentiated Carcinoma of the Liver With Rapid Bone Metastasis

Incidence and prognosis of undifferentiated cancers of the digestive system: a population-based cohort study

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