A Longitudinal Analysis of Memory in Patients with Schizophrenia

Tyson, Philip John; Laws, Keith R.; Roberts, Kate; Mortimer, Ann

doi:10.1080/13803390490918534

Cited by 19 publications

(9 citation statements)

References 56 publications

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“…Patients had impairment in the similarity test, which differed significantly from controls. There is a negative association between memory changes and psychotic symptoms [43], which is similar to our results, which show a negative correlation between the severity of symptoms and the cognitive performance (Table 4). This may be explained by the inability of chronic schizophrenic patients for planning, abstraction, and attention.…”

Section: Discussionsupporting

confidence: 91%

The association between cognitive functions, cortisol release, and symptom severity in patients with schizophrenia

Fathy¹,

Hamed²,

Ali³

2015

Middle East Current Psychiatry

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BackgroundThe evidence for hypothalamic-pituitary-adrenal axis dysfunction in schizophrenia has been reviewed in the context of the diathesis-stress model of schizophrenia. There is an inverse relation between the cortisol level and performance on the measure of hippocampal function, especially declarative memory. Aim of the work The aim of this study was to assess the cortisol level and cognitive deficits in schizophrenia and to assess the correlation between cognitive functions, the severity of positive and negative symptoms, and the cortisol level in patients with schizophrenia. Participants and methods This is a case-control cross-sectional study. After taking approval from the Scientific and Ethical Committee in Kasr El Aini Hospital, 30 patients diagnosed to have schizophrenia according to the DSM-IV criteria from the psychiatric outpatient clinic and inpatients from Kasr El Aini University Hospitals were recruited. All patients gave consent to participate in the study. Thirty control individuals (healthy volunteers among the medical and paramedical personnel staff of Kasr El Aini University Hospitals) were also included. All the scales show an absence of psychopathology in the control group. They were matched in age and sex. The following tools were used: all participants were subjected to a designed sociodemographic data sheet, the Positive and Negative Syndrome Scale, selected subtests from the Wechsler Adult Intelligence Scale, and selected subtests from the Wechsler Memory Scale-Revised. Laboratory tests included salivary samples for cortisol level assessment. ResultsAn elevated level of cortisol was observed in the patient group. There were highly significant statistical differences between the two groups regarding the cortisol level. There was no correlation between the Positive and Negative Syndrome Scale and the salivary cortisol level. ConclusionPatients with schizophrenia have impairment in their cognitive performance. The level of cortisol was elevated in patients with schizophrenia compared with normal people. There was no correlation between the cortisol level and symptom expression and the cognitive performance. There was a negative correlation between the cognitive performance and the severity of symptoms. 22 Chaudhury PK, Deka K, Chetia D. Disability associated with mental disorders. Indian J Psychiatry 2006; 48:95-101. 23 Byrne M, Agerbo E, Eaton WW, Mortensen PB. Parental socio-economic status and risk of first admission with schizophrenia -a Danish national register based study. Soc Psychiatry Psychiatr Epidemiol 2004; 39:87-96.Cognitive function, cortisol release in schizophrenia Fathy et al. 41

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Section: Discussionsupporting

confidence: 91%

The association between cognitive functions, cortisol release, and symptom severity in patients with schizophrenia

Fathy¹,

Hamed²,

Ali³

2015

Middle East Current Psychiatry

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“…There is accumulating evidence that this overall memory impairment is one of the core symptoms of SCZ. It is present in the early course of the disease (e.g., ), before the start of medication , and remains stable during the course of the disease . Impaired memory performance in unaffected twins and even in unaffected relatives (see for meta‐analysis, ) suggests a genetic basis.…”

Section: Introductionmentioning

confidence: 99%

Emotional memory modulation in schizophrenia: an overview

Dieleman

Röder

2012

Acta Psychiatr Scand

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“…For example, SWM deficits have been shown in the whole schizophrenia spectrum, including individuals with ultra‐high risk for psychosis (Smith, Park, & Cornblatt, ; Wood et al, ), first‐episode patients (Hutton et al, ), and those with chronic schizophrenia (Conklin, Curtis, Calkins, & Iacono, ). Further, Tyson, Laws, Roberts, and Mortimer () showed that SWM deficits in patients with schizophrenia remained stable over an 18‐month interval from the first onset of the illness. Park and Gooding () also suggested that WM deficits may be largely independent of the effect of medications.…”

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confidence: 99%

Heritability estimates of spatial working memory and set‐shifting in a healthy Chinese twin sample: A preliminary study

Zhou

Xie

et al. 2018

PsyCh Journal

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Impairments in spatial working memory (SWM) and set-shifting abilities have both been consistently observed in individuals with schizophrenia and are considered to be potential endophenotypes of this illness. However, an endophenotype needs to fulfill a set of stringent criteria, including heritability. This study examined the heritability of these two functions in a healthy Chinese twin sample. Forty-five pairs of monozygotic (MZ) twins and 35 pairs of dizygotic (DZ) twins completed the SWM task and the Intra-Extra Dimensional Set-Shifting (IED) task of the Cambridge Neuropsychological Test Automated Battery (CANTAB). We found a moderate heritability for SWM, of which the familial/genetic factors accounted for 33% of the total variance. However, we failed to find any significant heritability for set-shifting ability, of which the specific environmental factor explained most of the variance (85%). The preliminary findings from this small healthy Chinese twin sample suggest that SWM is heritable, whereas the set-shifting ability may reflect "extra-genetic" influences.

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A Longitudinal Analysis of Memory in Patients with Schizophrenia

Cited by 19 publications

References 56 publications

The association between cognitive functions, cortisol release, and symptom severity in patients with schizophrenia

The association between cognitive functions, cortisol release, and symptom severity in patients with schizophrenia

Emotional memory modulation in schizophrenia: an overview

Heritability estimates of spatial working memory and set‐shifting in a healthy Chinese twin sample: A preliminary study

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