A longitudinal analysis of neurocognitive function in unipolar depression

Biringer, Eva; Mykletun, Arnstein; Sundet, Kjetil; Kroken, Rune A.; Stordal, Kirsten Irene; Lund, Anders

doi:10.1080/13803390601147686

Cited by 84 publications

(67 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, in this study, HAM-D7 scores were found to be more important for predicting symptomatic improvement than DST scores used to assess verbal WM, a finding well in line with that reported by Biringer et al (2007), who showed that neurocognitive function at baseline did not predict amelioration of depressive symptoms over time in young adults. The present results, however, suggest verbal WM to be more important for predicting functional out- comes than depressive symptoms.…”

Section: Discussionsupporting

confidence: 79%

Working Memory in Patients with Major Depressive Disorder

Kaneda¹

2012

PSYCH

View full text Add to dashboard Cite

Objective: Patients with major depressive disorder (MDD) have been reported to perform less well in neurocognitive tests than normal control subjects. The author tested the hypotheses that verbal working memory (WM) is predictive of the functional outcome in patients with MDD. Methods: In this naturalistic longitudinal study, the subjects consisted of 22 adult outpatients receiving paroxetine as antidepressant therapy. Functional outcome was rated on a scale of 0 (non-impaired) to 3 (severely impaired). Results: 1) At 12 weeks, nine of the 22 patients currently experiencing MDD exhibited full remission; 2) significantly decreased 7-item Hamilton Rating Scale for Depression (HAM-D7) scores were observed during the 12-week study period, while Digit Sequencing Task (DST) scores increased significantly; 3) at baseline, functional outcomes correlated significantly with HAM-D7 scores, but, at 12 weeks, correlated significantly with both HAM-D7 and DST scores. Furthermore, when looking at only patients in full or partial remission (mild depression), functional outcome correlated more strongly with DST than with HAM-D7 scores. Conclusions: A deficit of verbal WM correlated with the functional outcome after treatment in patients with MDD. Antidepressant therapy with paroxetine might contribute to improvement of verbal WM.

show abstract

Section: Discussionsupporting

confidence: 79%

Working Memory in Patients with Major Depressive Disorder

Kaneda¹

2012

PSYCH

View full text Add to dashboard Cite

show abstract

“…This sparing concerns not only processing speed, working memory and overall executive functioning, but also episodic memory performances thought to be particularly vulnerable in the long-term evolution of EOD [5]. As already suggested in younger adults [39], this vulnerability may be related to the acute stages of the disease and be reversible. Two previous reports also challenged the deleterious effect of chronic depression in cognition [13,14].…”

Section: Discussionmentioning

confidence: 93%

Neurocognitive deficits and personality traits among euthymic patients with mood disorders in late life

Canuto

Giannakopoulos

Moy

et al. 2010

Journal of the Neurological Sciences

View full text Add to dashboard Cite

“…25 The BDI measures severity of depression and classifies results as minimal (score, 0-11), mild (score, [12][13][14][15][16][17][18][19], moderate (score, 20-35), or severe (score, 36-63).…”

Section: Instruments and Outcome Measuresmentioning

confidence: 99%

“…17 For instance, neurocognitive function at baseline was not predictive of symptom improvement in depression. 18 Although some speculate that cognition may mediate change in psychotherapy, 3 a definite statement that neurocognitive processes serve as mediators of therapeutic change would be premature, because researchers are only beginning to study the relationship between neurocognition and treatment outcome. For this reason, using neurocognitive variables as possible predictors is relevant for intervention research.…”

Section: Introductionmentioning

confidence: 99%

Predictors of response in the treatment of moderate depression

Bastos

Guimarães

Trentini

2016

Rev. Bras. Psiquiatr.

View full text Add to dashboard Cite

Objective: To identify neurocognitive and sociodemographic variables that could be associated with clinical response to three modalities of treatment for depression, as well as variables that predicted superior response to one treatment over the others. Method: The present study derives from a research project in which depressed patients (n=272) received one of three treatments -long-term psychodynamic psychotherapy (n=90), fluoxetine therapy (n=91), or a combination thereof (n=91) -over a 24-month period. Results: Sociodemographic variables were not found to be predictive. Six predictive neurocognitive variables were identified: three prognostic variables related to working memory and abstract reasoning; one prescriptive variable related to working memory; and two variables found to be moderators. Conclusions:The results of this study indicate subgroups of patients who might benefit from specific therapeutic strategies and subgroups that seem to respond well to long-term psychodynamic psychotherapy and combined therapy. The moderators found suggest that abstract reasoning and processing speed may influence the magnitude and/or direction of clinical improvement.

show abstract

A longitudinal analysis of neurocognitive function in unipolar depression

Cited by 84 publications

References 45 publications

Working Memory in Patients with Major Depressive Disorder

Working Memory in Patients with Major Depressive Disorder

Neurocognitive deficits and personality traits among euthymic patients with mood disorders in late life

Predictors of response in the treatment of moderate depression

Contact Info

Product

Resources

About