A longitudinal epidemiological study on the triglyceride and glucose index and the incident nonalcoholic fatty liver disease

Abstract

BackgroundTriglyceride and glucose (TyG) index and nonalcoholic fatty liver disease (NAFLD) both bave been related to insulin resistance (IR). The study aimed to investigate the longitudinal relationship between TyG index and NAFLD and to evaluate the ability of TyG, through comparing with the predictive value of other indexes, to identify individuals at risk for NAFLD.MethodsFour thousand and five hundred thirty nine subjects without NAFLD initially were followed up for 9 years. Cox regression models were used to analyze the risk factors of NAFLD.ResultsCox regression analyses indicated the TyG index was independently and positively associated with the risk of incident NAFLD. In receiver operating characteristic (ROC) curve analysis, the optimal cut-off level for TyG to predict incident NAFLD was 8.52 and the area under the ROC curve (AUC) was 0.76 (95% CI 0.74–0.77), which was larger than that of TG, ALT and FPG.ConclusionThis study demonstrated that the elevation of the TyG index might predict increase risk for incident NAFLD and it may be suitable as a diagnostic criterion for NAFLD.

Triglyceride and Glucose Index (TyG) is a Reliable Biomarker to Predict Non-Alcoholic Fatty Liver Disease

“…In our study, it was observed that mean age of NAFLD patients was 39 (±11.27) years and that of control group was 37 (±12.28) years, the difference of mean age between the groups was not statistically significant (p = 0.258). These finding was consistent with previous studies [15] [20] [21]. While, in a study by Lee et al the mean age of NAFLD patients was 53.11 (±8.58) years and in control group that was 52.29 (±9.70) years [5].…”

“…Zhang et al have shown that the mean TyG index was 8.8 (ranged 8.4 -9.3) in NAFLD patients and 8.2 (ranged 7.8 -8.6) in control group, which was statistically significant (p < 0.0001) [10]. was statistically significant (p < 0.0001) [15]. Simental-Mendia et al showed that the mean TyG index was 4.95 (±0.22) in NAFLD patients and 4.50 (±0.28) in control group, which was statistically significant (p < 0.001) [25].…”

“…Zhang et al found the AUC was 0.782 (0.773 -0.793) for diagnosis of NAFLD [10]. Another study by Zheng et al found the AUC to predict the development of NAFLD was 0.76 (0.74 -0.77) [15]. Yu et al found the AUC of the ROC curve for TyG index for metabolic unhealthy male was 0.863 (95% CI, 0.857 -0.869) and in female that was 0.867 (95% CI, 0.862 -0.872) [26].…”

The triglyceride-glucose index is associated with the severity of hepatic steatosis and the presence of liver fibrosis in non-alcoholic fatty liver disease: a cross-sectional study in Chinese adults

“…Additionally, the correlation of the TyG index with NAFLD has drawn interest. Two studies, one cross-sectional and the other prospective, have both shown that the TyG index is a predictor of incident NAFLD, and both concluded that it may be a good diagnostic tool for NAFLD [16,17]. However, little is known about the link between the TyG index and liver fibrosis or the severity of hepatic steatosis in NAFLD.…”

Relationship between visceral adipose tissue and triglyceride glucose index with liver status in men and women with metabolic syndrome features: sex differences

“…The TyG index is a newly described marker that has been reported as a useful screening tool for insulin resistance [21,33,34], NAFLD [35] and as an early predictor of MetS features [36]. This marker was calculated using biochemical data according to the following formula [33],…”