Many studies have considered that the earlier stages of addictive substance use, which normally appear in adolescence, are influenced by various psychological and personality aspects, among which the most relevant are the seeking of new sensations and impulsiveness but also antisocial behaviour, which is the subject of the present study. In this case, the main objective was to determine the differential influence of antisocial behaviour in the consumption of illegal drugs (cannabis, morphine-derived substances, stimulants, synthetic drugs, cocaine) in a sample of 1570 adolescents from the Madrid Region utilising the Antisocial Behaviour Scale (Allsopp and Feldman, 1976) and an ad hoc questionnaire designed for this study to estimate the use of the different substances. The results obtained show a close connection between a higher and more frequent use of the substances stated above and a higher presence of behaviours against social norms. Unlike the males, the females, who show a more antisocial behaviour have a significantly higher consumption of stimulants and synthetic drugs than those who show this kind of conduct less frequently.