A Longitudinal Study of <i>Streptococcus mutans</i> Colonization in Infants after Tooth Eruption

Wan, A. K. L.; Seow, W.K.; Purdie, David M.; Bird, P. S.; Walsh, Laurence J.; Tudehope, DI

doi:10.1177/154405910308200703

Cited by 140 publications

(195 citation statements)

References 14 publications

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“…Adaptation of S. mutans to the DMBT1 SAG phenotype of different mouths reflects a more recent evolutionary time scale than adaptation of DMBT1 in humans. However, given that S. mutans colonizes the mouth in early childhood (38) and the doubling time of biofilm-attached S. mutans is in the order of hours (39), it is likely that it can adapt genetically to the oral environment. We genotyped 125 adult individuals resident in Leicester U.K., 92 of European origin, for CNV1 and CNV2, and sequenced part of the S. mutans gene spaP from DNA isolated from matched saliva.…”

Section: Resultsmentioning

confidence: 99%

Evolution of the rapidly mutating human salivary agglutinin gene ( DMBT1 ) and population subsistence strategy

Polley

Louzada

Forni

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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The dietary change resulting from the domestication of plant and animal species and development of agriculture at different locations across the world was one of the most significant changes in human evolution. An increase in dietary carbohydrates caused an increase in dental caries following the development of agriculture, mediated by the cariogenic oral bacterium Streptococcus mutans. Salivary agglutinin [SAG, encoded by the deleted in malignant brain tumors 1 (DMBT1) gene] is an innate immune receptor glycoprotein that binds a variety of bacteria and viruses, and mediates attachment of S. mutans to hydroxyapatite on the surface of the tooth. In this study we show that multiallelic copy number variation (CNV) within DMBT1 is extensive across all populations and is predicted to result in between 7-20 scavenger-receptor cysteinerich (SRCR) domains within each SAG molecule. Direct observation of de novo mutation in multigeneration families suggests these CNVs have a very high mutation rate for a protein-coding locus, with a mutation rate of up to 5% per gamete. Given that the SRCR domains bind S. mutans and hydroxyapatite in the tooth, we investigated the association of sequence diversity at the SAG-binding gene of S. mutans, and DMBT1 CNV. Furthermore, we show that DMBT1 CNV is also associated with a history of agriculture across global populations, suggesting that dietary change as a result of agriculture has shaped the pattern of CNV at DMBT1, and that the DMBT1-S. mutans interaction is a promising model of host-pathogenculture coevolution in humans.copy number variation | agriculture | DMBT1 | mutation | structural variation

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Section: Resultsmentioning

confidence: 99%

Evolution of the rapidly mutating human salivary agglutinin gene ( DMBT1 ) and population subsistence strategy

Polley

Louzada

Forni

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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“…Low birthweight, including preterm births, predisposes to high levels of streptococcal colonization, 45 in addition to favoring the development of enamel hypoplasia and salivary disorders. 30,43 In these newborns, enamel defects are associated with gestational diseases, such as maternal infection, metabolic disorders (hypoxemia, nutritional disorders, hypocalcemia) and performance of medical procedures (laryngoscopy and endotracheal intubation).…”

Section: Susceptible Hostmentioning

confidence: 99%

Aleitamento materno e cárie do lactente e do pré-escolar: uma revisão crítica

Ribeiro¹,

Ribeiro²

2004

J. Pediatr. (Rio J.)

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“…25 Subsequently, poor maternal oral hygiene and higher sugar intake per day rise the chances of transferring the disease to the child by the mother. 26 Whereas, for horizontal transmission, neonatal factors may increase the chance of acquiring SM. Infant delivery by cesarean section transmits SM earlier than through natural deliveries.…”

Section: Microbiological Risk Factorsmentioning

confidence: 99%

Early Childhood Caries: A Review

Alazmah¹

2017

The Journal of Contemporary Dental Practice

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Aim: To review and update the current knowledge about early childhood caries (ECC) and its etiology, prevalence, risk factors, management, and preventive strategies. Background:Early childhood caries is a disease affecting significantly both well-developed and industrial nations. The ECC can significantly affect the child's quality of life, as it may lead to infection, swelling, pain, and other symptoms. The ECC affects children after eruption of primary teeth until age of around 5 years. Review results:The ECC affects all parts of the tooth including the smooth surface. Upper anterior teeth and primary molars are usually affected. The lower anterior teeth are less likely affected. The risk factors for ECC are diet, bacteria, and host susceptibility. The additional factors, such as presence of enamel defect and the feeding practices also contribute to the initiation and progress of ECC. Conclusion:Dentists must focus on utilizing existing techniques to distinguish indications of right on time and propelled caries and give guidance on the best way to counteract and control caries in children. Approaches should be directed to preventive caries control strategies among children.Clinical significance: Preventing and controlling the development of ECC among children is important to maintain effective eating, speech development, and formation of a positive self-image.

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A Longitudinal Study of Streptococcus mutans Colonization in Infants after Tooth Eruption

Cited by 140 publications

References 14 publications

Evolution of the rapidly mutating human salivary agglutinin gene ( DMBT1 ) and population subsistence strategy

Evolution of the rapidly mutating human salivary agglutinin gene ( DMBT1 ) and population subsistence strategy

Aleitamento materno e cárie do lactente e do pré-escolar: uma revisão crítica

Early Childhood Caries: A Review

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