A longitudinal study of immunological parameters in multiple sclerosis

Mar, Pearl; Gradl, T.; Dörner, Christa

doi:10.1016/0022-510x(79)90096-0

Cited by 13 publications

(11 citation statements)

References 23 publications

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“…Multiple sclerosis (MS) is a central nervous system (CNS) demyelinating disease that may have an autoimmune cause. Observations have been reported of abnormal cell-mediated responses to mitogens [16,21,23] and viruses [38,40] in some MS patients, while other reports have indicated the presence of elevated titers of antibody to measles virus [l, 22,241, anti-smooth muscle antibody [18], and complement-dependent rnyelinotoxic and gliotoxic factors in the serum and cerebrospinal fluid of some MS patients [ 121. Within the CNS, most MS patients exhibit abnormal de novo IgG synthesis [22, 25, 351, the presence of oligoclonal IgG demonstrated by electrophoretic techniques [9,11,151, and the presence of T cells during active disease which are stimulated in vitro by myelin basic protein [ 141.…”

mentioning

confidence: 99%

Abnormal regulation of in vitro IgG production in multiple sclerosis

Kelley

Ellison

Myers

et al. 1981

Annals of Neurology

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A pokeweed mitogen-stimulated IgG synthesis assay was used to evaluate T suppressor cell function in peripheral blood lymphocytes (PBL) obtained from multiple sclerosis (MS) patients. Autochthonous cultures of fractionated and recombined MS B and T cells exhibited less suppression of IgG synthesis than similar cultures of PBL from control subjects. No difference occurred in the levels of suppression among MS patients grouped according to disease states. When allogenic cultures of MS B and normal T cells or normal B and MS T cells were compared to autochthonous cultures of control cells, no differences were observed. The results suggest that the lower levels of suppression observed in autologous MS cell cultures are not a result of T suppressor cell dysfunction alone.

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mentioning

confidence: 99%

Abnormal regulation of in vitro IgG production in multiple sclerosis

Kelley

Ellison

Myers

et al. 1981

Annals of Neurology

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“…Active E-RFC counts have been comparatively sparingly performed in MS, nevertheless, conflicting results have been obtained: increased levels ( 1 9), normal levels (4, 6, 8, I I , 18,26) and decreased levels (10, 14). Our results are in accordance with the majority, but in our opinion the possibility remains that more extensive studies with E from several different sheep might reveal differences in active E-RFC as well as for total E-RFC counts.…”

Section: Discussionmentioning

confidence: 99%

Lymphocyte Subpopulations in Multiple Sclerosis: Variations in Rosette Tests Using Erythrocytes From Different Sheep

Naess

Nyland

1980

Acta Pathologica Microbiologica Scandinavica Section C Immunolo

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Nzss, A. & Nyland, H. Lymphocyte subpopulations in multiple sclerosis: Variations in rosette tests using erythrocytes from different sheep. Acta path. rnicrobiol. scand. Sect. C, 88: 293-297. IYXO. Lymphocytes from 34 patients with active and with stable multiple sclerosis (MS) were examined by rosetting techniques. Patients with active disease had a relative lymphopenia (35 f 9 % ). When tested with erythrocytes (E) from one out of three sheep used, patients with active MS had a decrease in Erosette forming cells (E-RFC) compared to patients with stable disease and with healthy controls. Other tests (active E-, EAET, EA-, and EAC-RFC) did not disclose any differences between patients and controls. The results suggest that the origin of the E may be of importance in E-RFC tests. Membrane marker techniques are a relatively simple method for the demonstration of lymphocyte subpopulations. T lymphocytes have receptors for sheep erythrocytes (El, and form rosettes with these (E-rosette forming cells, E-RFC). A subpopulation of E-RFC also form rosettes under suboptimal conditions (low E:lymphocyte ratio, minimal incu-

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“…At present relatively few studies of the longitudinal course of MS and CIC or complement are available. Fluctuations in the C3 level have been suggested as a possible marker of disease activity (Mar et al 1979), and the occurrence of CIC has been correlated to rapid progression of the disease ( J a m et al 1979( J a m et al , Patzold et al 1980.…”

Section: The Occurrence Of a Negative Regression Of Tnd On C4 Hnd C3-mentioning

confidence: 99%

“…Detection of immunoglobulin G and complement factor Clq deposits in brain plaques (Woyciechowska & Brzosko 1977) further suggests a decisive role of IC in MS. Previously performed studies have reported weak but promising relations between the clinical appearance of MS, the occurrence of circulating immune complexes (Jans et al 1979, Patzold et al 1980, and fluctuations in the concentration of the complement factor C3 (Mar et al 1979).…”

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confidence: 99%

Circulating immune complexes and complement in the course of multiple sclerosis

Jans

Heltberg

Raun

2009

Acta Neurologica Scandinavica

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To evaluate the reactions of the humoral immune response in the course of multiple sclerosis (MS), 21 patients were examined approximately 10 times at regular intervals for 1 year. The study included concomitant investigations of the total neurological deficit (TND) and laboratory analyses of the complement profile, detection of circulating immune complexes (CIC) and heterophilic antibodies (HPA).CIC were found in 58.7 % of the investigations, often with simultaneous activation of C4 and C3. The mean values of the complement levels of the MS patients, however, did not differ from the values in a normal population. The consecutive investigations demonstrated a negative regression of TND on C4 from one month previously, a concomitant negative regression of TND on C3 and a positive regression of CIC from one month subsequently on TND. No significant relation between the clinical type of the disease and the occurrence of CIC was demonstrated, but the occurrence of attacks seemed to correlate with development of HPA.

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A longitudinal study of immunological parameters in multiple sclerosis

Cited by 13 publications

References 23 publications

Abnormal regulation of in vitro IgG production in multiple sclerosis

Abnormal regulation of in vitro IgG production in multiple sclerosis

Lymphocyte Subpopulations in Multiple Sclerosis: Variations in Rosette Tests Using Erythrocytes From Different Sheep

Circulating immune complexes and complement in the course of multiple sclerosis

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