A longitudinal study of neuromelanin-sensitive magnetic resonance imaging in Parkinson’s disease

Matsuura, Keita; Maeda, Masayuki; Tabei, Ken-ichi; Umino, Maki; Kajikawa, Hiroyuki; Satoh, Masayuki; Kida, Hirotaka; Tomimoto, Hidekazu

doi:10.1016/j.neulet.2016.09.011

Cited by 65 publications

(76 citation statements)

References 19 publications

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“…Matsuura et al . , in a longitudinal study of NSMRI in PD, reported a significant reduction in area and CR of the SNc in follow‐up images of patients with PD. Additionally, in our study the UPDRS‐III OFF‐state scores (motor scores) also correlated with CRs of the central and lateral SNc.…”

Section: Discussionmentioning

confidence: 93%

Three‐dimensional neuromelanin‐sensitive magnetic resonance imaging of the substantia nigra in Parkinson's disease

Prasad

Stezin

Lenka

et al. 2018

Euro J of Neurology

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Section: Discussionmentioning

confidence: 93%

Three‐dimensional neuromelanin‐sensitive magnetic resonance imaging of the substantia nigra in Parkinson's disease

Prasad

Stezin

Lenka

et al. 2018

Euro J of Neurology

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“…A recent study has investigated longitudinal changes in the area and CR of the SNc in a small cohort of 14 patients with PD . After a follow‐up of 2.3 ± 1.1 years (range 1.0–4.9 years), both the total area and the CR of the SNc were significantly smaller compared to baseline imaging (from 33.5 ± 18.9 pixels and 6.35 ± 2.86% to 21.5 ± 16.7 pixels and 4.19 ± 2.11%).…”

Section: Neuromelanin Sensitive Mrimentioning

confidence: 99%

Nigrosome Imaging and Neuromelanin Sensitive MRI in Diagnostic Evaluation of Parkinsonism

Pavese

Tai

2018

Movement Disord Clin Pract

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Background Recent developments in magnetic resonance imaging (MRI) techniques have offered new research opportunities to visualize in vivo substantia nigra pathology in Parkinson's disease (PD). This paper summarizes the main findings of nigrosome imaging and neuromelanin sensitive MRI studies in patients with PD and other parkinsonisms. Methods The PubMed database was searched from 2005 to 2017 using the following keywords: Parkinson's disease and parkinsonism, in combination with MRI, nigrosome, neuromelanin, and iron. Only publications in English were included. Results Nigrosome or dorsal nigral hyperintensity abnormalities are studied using T2* and susceptibility weighted imaging MRI sequences in most studies, whereas Neuromelanin imaging is usually performed using T1‐weighted fast spin echo sequence. Nigrosome abnormalities have been consistently demonstrated in PD patients, and nigrosome imaging has high sensitivity and specificity in distinguishing PD from healthy controls, though it is unable to reliably separate PD from atypical parkinsonisms. Reduced neuromelanin‐related signals and/or volume loss in neuromelanin containing structures have been found in PD patients, and neuromelanin sensitive MRI imaging can also discriminate PD patients from healthy controls with high accuracy, though there is a degree of heterogeneity in the imaging findings. Preliminary findings suggested that longitudinal change of neuromelanin signal could be detected in PD, raising the possibility of using it as a marker of disease progression. Conclusion Nigrosome imaging and neuromelanin sensitive MRI are promising tools to study nigral pathology and to improve the diagnosis of PD. However, further studies are required to standardize analysis approaches, confirm longitudinal changes, and assess their generalizability.

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“…Neuromelanin chelated with ferric iron has paramagnetic properties with subsequent T1 shortening . High‐resolution short–echo time T1‐weighted MRI scans with additional magnetization transfer contrast allows reliable and sensitive detection of paramagnetic neuromelanin in the SN pars compacta and locus coeruleus . The corresponding T1 hyperintensity is considered to reflect the amount of ferric iron bound to NM .…”

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confidence: 99%

Life span pigmentation changes of the substantia nigra detected by neuromelanin‐sensitive MRI

et al. 2018

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Background : Neuromelanin is a pigment with strong iron‐chelating properties preferentially found in dopaminergic neurons of the substantia nigra pars compacta (SNpc). Parkinson's disease is characterized by pronounced, MRI‐detectable neuromelanin loss, but the neuroprotective or neurotoxic role of neuromelanin remains debated. Histological studies have demonstrated neuromelanin increases with age, but this has not been confirmed in vivo, and there is uncertainty whether neuromelanin declines, stabilizes, or increases from middle age. Methods : This study aimed to establish physiological changes of pigmentation of the SNpc using a pooled data set of neuromelanin‐sensitive 3T MRI from 134 healthy individuals aged 5‐83 years. Neuromelanin‐related brightness (regional contrast to ratio) and calibrated hyperintense volumes were analyzed using linear and nonlinear regression models to characterize age effects. Laterality, sex, and subregional effects were also assessed. Results : For brightness, age effects were best described as a quadratic trajectory explaining 81.5% of the observed variance in the SNpc showing a strong increase from childhood to adolescence, with plateauing in middle age and a decline in older age. Similar but less pronounced effects were seen in hyperintense volumes. We also show an anterior‐posterior gradient in SNpc contrast, larger normalized neuromelanin‐rich volume in women > 47 years old, but no laterality effect. Conclusions : Using optimized neuromelanin MRI in a life span sample, we demonstrate a strong age effect with inverted U‐shaped SNpc pigmentation‐related contrast from childhood to old age. This age trajectory of physiological SNpc pigmentation needs to be taken into account for diagnostic applications of depigmentation. The study also paves the way for systematic investigations of the mechanisms of neuromelanin in healthy and pathological brain development and aging. © 2018 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

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A longitudinal study of neuromelanin-sensitive magnetic resonance imaging in Parkinson’s disease

Cited by 65 publications

References 19 publications

Three‐dimensional neuromelanin‐sensitive magnetic resonance imaging of the substantia nigra in Parkinson's disease

Three‐dimensional neuromelanin‐sensitive magnetic resonance imaging of the substantia nigra in Parkinson's disease

Nigrosome Imaging and Neuromelanin Sensitive MRI in Diagnostic Evaluation of Parkinsonism

Life span pigmentation changes of the substantia nigra detected by neuromelanin‐sensitive MRI

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