A longitudinal study of occlusal caries in Newark New Jersey school children: Relationship between initial dental finding and the development of new lesions

Markowitz, Kenneth; Fairlie, Karen; Ferrandiz, Javier; Nasri-Heir, Cibele; Fine, Daniel H.

doi:10.1016/j.archoralbio.2012.07.001

Cited by 5 publications

(4 citation statements)

References 29 publications

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“…The initial screening visit was performed in a mobile dental van and consisted of a full oral and dental examination, review of medical and dental histories, and collection of saliva and buccal epithelial cells (BECs) from each subject as described previously (5,22). Subjects were excluded if they required prophylactic antibiotics, had any bleeding disorder, were otherwise medically vulnerable, or if they had extensive dental caries as defined by decayed, missing, or filled surfaces (23).…”

Section: Methodsmentioning

confidence: 99%

A Consortium of Aggregatibacter actinomycetemcomitans, Streptococcus parasanguinis, and Filifactor alocis Is Present in Sites Prior to Bone Loss in a Longitudinal Study of Localized Aggressive Periodontitis

et al. 2013

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c Aggregatibacter actinomycetemcomitans-induced localized aggressive periodontitis (LAP) in African-American adolescents has been documented but is poorly understood. Two thousand fifty-eight adolescents aged 11 to 17 years were screened for their periodontal status and the presence of A. actinomycetemcomitans in their oral cavity. Seventy-one A. actinomycetemcomitansnegative and 63 A. actinomycetemcomitans-positive periodontally healthy subjects were enrolled, sampled, examined, and radiographed yearly for 3 years. Gingival and periodontal pocket depth and attachment levels were recorded. Disease presentation was characterized by bone loss (BL). Subgingival sites were sampled every 6 months to assess (i) the role of A. actinomycetemcomitans in BL and (ii) the association of A. actinomycetemcomitans and other microbes in their relationships to BL. Sixteen of 63 subjects with A. actinomycetemcomitans developed BL (the other 47 subjects with A. actinomycetemcomitans had no BL). No A. actinomycetemcomitans-negative subjects developed BL. Human oral microbe identification microarray (HOMIM) was used for subgingival microbial assessment. On a subject level, pooled data from A. actinomycetemcomitans-positive subjects who remained healthy had higher prevalences of Streptococcus and Actinomyces species, while A. actinomycetemcomitans-positive subjects with BL had higher prevalences of Parvimonas micra, Filifactor alocis, A. actinomycetemcomitans, and Peptostreptococcus sp. human oral taxon 113 (HOT-113). At vulnerable sites, A. actinomycetemcomitans, Streptococcus parasanguinis, and F. alocis levels were elevated prior to BL. In cases where the three-organism consortium (versus A. actinomycetemcomitans alone) was detected, the specificity for detecting sites of future BL increased from 62% to 99%, with a sensitivity of 89%. We conclude that detecting the presence of A. actinomycetemcomitans, S. parasanguinis, and F. alocis together indicates sites of future BL in LAP. A synergistic interaction of this consortium in LAP causation is possible and is the subject of ongoing research.

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Section: Methodsmentioning

confidence: 99%

A Consortium of Aggregatibacter actinomycetemcomitans, Streptococcus parasanguinis, and Filifactor alocis Is Present in Sites Prior to Bone Loss in a Longitudinal Study of Localized Aggressive Periodontitis

et al. 2013

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“…As such, detection of caries is not only an important issue for clinical research (e.g., Kumar at al., 2010;Knevel and Gussy, 2012;Markowitz et al, 2012) but also for anthropological and archaeological studies (e.g., Ezzo, 1992;Belcastro et al, 2007;Esclassan et al, 2009;Wasterlain et al, 2009;Tomczyk et al, 2013a). Their study can provide information on the dietary behavior, hygiene, and socioeconomic status of past and present human populations.…”

mentioning

confidence: 99%

“…Their study can provide information on the dietary behavior, hygiene, and socioeconomic status of past and present human populations. As such, detection of caries is not only an important issue for clinical research (e.g., Kumar at al., 2010;Knevel and Gussy, 2012;Markowitz et al, 2012) but also for anthropological and archaeological studies (e.g., Ezzo, 1992;Belcastro et al, 2007;Esclassan et al, 2009;Wasterlain et al, 2009;Tomczyk et al, 2013a).…”

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confidence: 99%

Fluorescence methods (VistaCam iX proof and DIAGNODent pen) for the detection of occlusal carious lesions in teeth recovered from archaeological context

Tomczyk

Komarnitki

Zalewska

et al. 2014

American J Phys Anthropol

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Diagnosis of occlusal enamel caries in archaeologically derived collections remains a controversial problem because the accumulation of contaminants in fissures can interfere with diagnosis. Certain novel light-induced fluorescence methods, such as the DIAGNODent pen 2190 (DD) and VistaCam iX Proof (VC), have been used to detect dental caries in clinical settings. In this study, the abilities of DD and VC to detect initial enamel caries in archaeologically derived material is determined and compared with those of other methods (visual inspection, X-ray, histology, and micro-CT). Dental material encompassing the remains of 58 individuals, including a total of 380 teeth from each of three historical periods: modern Islamic (AD 1850-1950), Islamic (AD 600-1200) and late Roman (AD 200-400), obtained from two archaeological sites (Terqa and Tell Masaikh) located in the Middle Euphrates valley (Syria), were analyzed. VC was found to have excellent sensitivity (98), while DD obtained lower sensitivity (76) in detecting dental caries in its early stages. The results obtained by VC and micro-CT, considered the most reliable imaging technique, were not statistically significant (P = 0.3068). By contrast, results obtained by DD and micro-CT results, and DD and VC results were statistically significant (P < 0.0001, P = 0.0015, respectively). However the presence of dirt, stain, calculus, and plaque in the pits and fissures of the occlusal surface compromise correct diagnosis of caries by VC and DD. Consequently, for teeth recovered from archaeological contexts where staining, calculus and plaque are present, the best solution remains micro-CT.

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“…To demonstrate the value OHRQoL can bring to caries research, we recently analyzed OHRQOL COHIP data from a sample of underserved pediatric patients who were being evaluated/treated for caries as part of a larger study [29]. The sample includes 102 school children from Newark, NJ.…”

Section: Ohrqol In Pediatric Caries Researchmentioning

confidence: 99%

An Overview of Children's Oral Health-Related Quality of Life Assessment: From Scale Development to Measuring Outcomes

Genderson¹,

Sischo²,

Markowitz³

et al. 2013

Caries Res

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The objectives of this paper are to present an overview of children's oral health-related quality of life and include specific applications for using quality of life assessment in dental research. The process of developing pediatric oral health- related quality of life measures, in particular the Child Oral Health Impact Profile, is outlined. Examples of children's oral health-related quality of life measurement in caries research are also provided. Quality of life outcomes are presented and discussed in the context of caries research. Lastly, the relevance of measuring clinically meaningful difference in the context of measuring outcomes research is highlighted with recommendations for future research.

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A longitudinal study of occlusal caries in Newark New Jersey school children: Relationship between initial dental finding and the development of new lesions

Cited by 5 publications

References 29 publications

A Consortium of Aggregatibacter actinomycetemcomitans, Streptococcus parasanguinis, and Filifactor alocis Is Present in Sites Prior to Bone Loss in a Longitudinal Study of Localized Aggressive Periodontitis

A Consortium of Aggregatibacter actinomycetemcomitans, Streptococcus parasanguinis, and Filifactor alocis Is Present in Sites Prior to Bone Loss in a Longitudinal Study of Localized Aggressive Periodontitis

Fluorescence methods (VistaCam iX proof and DIAGNODent pen) for the detection of occlusal carious lesions in teeth recovered from archaeological context

An Overview of Children's Oral Health-Related Quality of Life Assessment: From Scale Development to Measuring Outcomes

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