A Longitudinal Study of Sleep Disorders in Early-Stage Chronic Kidney Disease

Santo, Rosa Maria De; Bilancio, Giancarlo; Santoro, Domenico; Vecchi, Maurizio; Perna, Alessandra F.; Santo, Natale G. De; Cirillo, Massimo

doi:10.1053/j.jrn.2010.06.003

Cited by 25 publications

(17 citation statements)

References 24 publications

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“…Another beneficial effect of exercise found in our study was the improvement in sleep quality assessed by the PSQI questionnaire. In accordance with other studies in CKD patients, we also observed a mean PSQI score indicative of poor sleep quality at baseline [41,42]. It is well known that several disturbances related to the loss of renal function as well as obesity may affect the pattern of sleep [42,43].…”

Section: Discussionsupporting

confidence: 92%

Impact of home-based aerobic exercise on the physical capacity of overweight patients with chronic kidney disease

et al. 2014

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Section: Discussionsupporting

confidence: 92%

Impact of home-based aerobic exercise on the physical capacity of overweight patients with chronic kidney disease

et al. 2014

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“…The few clinical studies that examined the relationship between sleep quality and renal failure in CKD patients with early or end-stage disease have produced conflicting results [5,6]. The association between EDS and eGFR decline reported in our study was independent of cardiovascular diseases, which failed to support the hypothesis-mediating effect of cardiovascular diseases in the relationship between EDS and eGFR in the elderly.…”

Section: Discussioncontrasting

confidence: 85%

“…One study reported that patients with various degrees of chronic renal failure had progressively worse sleep quality over a 3-year follow-up [5]. Conversely, another study reported that patients newly diagnosed with CKD improved their sleep quality over a 4-year period [6]. These inconstancies could be attributed to differences in design, sample size, clinical setting and heterogeneity in CKD stages.…”

Section: Introductionmentioning

confidence: 99%

Impact of sleep disturbances on kidney function decline in the elderly

et al. 2015

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While sleep disturbances are frequent in renal disease patients, no studies have examined prospectively the associations between sleep disturbances and kidney function decline in communitydwelling elderly subjects.Glomerular filtration rates (eGFRs) were estimated at baseline and at 11-year follow-up. A glomerular filtration decline over the follow-up period was defined as a percentage decline greater than or equal to the cut-off value of the highest tertile of kidney function decline (22%) in 1105 subjects. Excessive daytime sleepiness (EDS) and insomnia complaints were self-rated at baseline. Restless legs syndrome (RLS) and its age at onset were assessed at study end-point. An ambulatory polysomnography recording was performed during the follow-up in 277 subjects. Apnoea-hypopnoea index (AHI), periodic limb movements during sleep (PLMS) and total sleep time were analysed.An increased risk of eGFR decline was associated with EDS (OR 1.67, 95% CI 1.18-2.34) and RLS (OR 1.98, 95% CI 1.18-3.30) independently of potential confounders including cardiovascular risk factors. Among insomnia complaints, a borderline association with eGFR decline was found for early morning awakening only. High AHI (⩾30 events·h ) and short total sleep time (<6 h), but not PLMS were linked to eGFR decline in crude associations, but only AHI remained significantly associated after multi-adjustments.EDS, RLS and AHI constitute independent risk factors for kidney glomerular function decline. @ERSpublications Excessive daytime sleepiness, restless legs syndrome and AHI are risk factors for kidney glomerular function decline

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“…Although end-stage renal disease patients have been reported to have a high prevalence of OSA (10,18), OSA among nondialysis CKD patients has not been fully investigated despite the high prevalence of sleep complaints in this population (12). Iseki et al reported that the prevalence of nondialysis CKD among sleep-disordered breathing patients was significantly higher than those in general screening populations (30.5% versus 9.1%) (19).…”

Section: Discussionmentioning

confidence: 99%

“…Among end-stage renal disease patients, the high prevalence of OSA and its influence on cardiovascular events have been reported (10,11). However, the association between nondialysis CKD and OSA has not been fully investigated, although sleep complaints are highly prevalent in this population (12). We conducted this crosssectional study to estimate the prevalence of OSA among nondialysis CKD patients in Japan, wherein we also investigated the association between OSA and renal function.…”

Section: Introductionmentioning

confidence: 99%

High Prevalence of Obstructive Sleep Apnea and Its Association with Renal Function among Nondialysis Chronic Kidney Disease Patients in Japan

Sakaguchi

Tanaka

Kawabata

et al. 2011

Clinical Journal of the American Society of Nephrology

122

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SummaryBackground and objectives Obstructive sleep apnea (OSA) affects one of five adults in the general population. Although a high prevalence of OSA has been reported among dialysis patients, the association between nondialysis chronic kidney disease (CKD) and OSA has not been fully investigated. This cross-sectional study aimed to investigate the prevalence of OSA among nondialysis CKD patients in Japan and the association between renal function and OSA.Design, setting, participants, & measurements Consecutive nondialysis CKD patients hospitalized mainly for CKD educational program, regardless of their sleep complaints, were enrolled. The diagnosis of OSA and its severity were measured using a type 3 portable monitor.Results Overall (n ϭ 100, 68.0% male, median age 66.5 years, body mass index [BMI] 23.1 kg/m 2 , estimated GFR [eGFR] 28.5 ml/min per 1.73 m 2 ), 65% were diagnosed as OSA: mild OSA (apnea-hypopnea index [AHI] 5.0 to 14.9) in 32%, moderate OSA (AHI 15.0 to 29.9) in 25%, and severe OSA (AHI Ն 30.0) in 8%. Multivariate logistic regression analysis revealed that a 10-ml/min per 1.73 m 2 decrease in eGFR was associated with a 42% increased odds of OSA after adjustment for age, BMI, and diabetes mellitus. Moreover, in a generalized linear model, eGFR was inversely correlated with AHI after adjustment for covariates.Conclusions This study demonstrated a high prevalence of OSA among nondialysis CKD patients in Japan and that the increased risk of OSA was significantly associated with decreased GFR among these patients. Further investigations are warranted to determine OSA's direct influence on cardiovascular disease.

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A Longitudinal Study of Sleep Disorders in Early-Stage Chronic Kidney Disease

Cited by 25 publications

References 24 publications

Impact of home-based aerobic exercise on the physical capacity of overweight patients with chronic kidney disease

Impact of home-based aerobic exercise on the physical capacity of overweight patients with chronic kidney disease

Impact of sleep disturbances on kidney function decline in the elderly

High Prevalence of Obstructive Sleep Apnea and Its Association with Renal Function among Nondialysis Chronic Kidney Disease Patients in Japan

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