A longitudinal study of the effect of different social rearing conditions on cerebrospinal fluid norepinephrine and biogenic amine metabolites in rhesus monkeys

Kraemer, Gary W.; Ebert, Michael H.; Schmidt, Dennis E.; McKinney, William T.

doi:10.1016/0893-133x(89)90021-3

Cited by 205 publications

(122 citation statements)

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“…There was a general decrease in the mean CSF 5-HIAA concentrations of the subjects as they increased in age (from two to six years of age), consistent with findings from normal human subjects (Bowers and Gerbode 1968;Langlais et al 1985;Rogers and Dubowitz 1970). We expected to find this trend in rhesus monkeys since previous studies have shown that CSF 5-HIAA concentrations are stable across time between individuals, but decrease with age as a group (Higley et al 1992b(Higley et al , 1996aKraemer et al 1989).…”

Section: Discussionsupporting

confidence: 84%

Seasonal Variation in CSF 5-HIAA Concentrations in Male Rhesus Macaques

Zajicek¹,

Price²,

Shoaf

et al. 2000

Neuropsychopharmacology

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Section: Discussionsupporting

confidence: 84%

Seasonal Variation in CSF 5-HIAA Concentrations in Male Rhesus Macaques

Zajicek¹,

Price²,

Shoaf

et al. 2000

Neuropsychopharmacology

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“…The SIB monkeys studied had average CSF 5-HIAA concentrations similar to those of normal monkeys, which is contrary to the findings of Kraemer et al (1989), who reported high CSF 5-HIAA concentrations among monkeys exhibiting SIB that were socially deprived during rearing. Rearing history (mother-or peer-deprived) (Fittinghoff et al 1974;Kraemer and Clarke 1990) can also affect the development of self-biting and its responsiveness to 5-HT (Kraemer and Clarke 1990).…”

Section: Discussioncontrasting

confidence: 56%

Effect of Tryptophan Treatment on Self-Biting and Central Nervous System Serotonin Metabolism in Rhesus Monkeys (Macaca mulatta)

Weld

Mench

Woodward

et al. 1998

Neuropsychopharmacology

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Two studies were conducted to examine the effects of oral L-tryptophan (TRP) supplementation as a treatment for self-injurious behavior (SIB) and to investigate behavior Meyer-Holzapfel 1968;Jones and Barraclough 1978). In humans, SIB has been described as representing a continuum of behavior ranging from occasional noninjurious biting, scratching, and head banging to persistent self-biting and cutting associated with severe physical injuries (Harris 1995;Walsh and Rosen 1988). SIB also occurs in rhesus monkeys, most often as a result of self-biting (Tinklepaugh 1928;Erwin et al. 1973;Capitanio 1986). A retrospective study documenting the incidence of wounding in three primate colonies (Bayne et al. 1995) showed that, of 253 monkeys studied, 0.8% engaged in self-injurious behavior that resulted in wounds requiring veterinary treatment. Although severe self-biting in nonhuman primates is a relatively uncommon phenomenon, it nevertheless remains a serious concern, because it can lead to severe and sometimes fatal injuries.

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“…Kraemer, Ebert, Schmidt, and McKinney (1989) showed in their study of rhesus monkeys that disruption of early social attachment, an important factor in the development of vulnerability to psychopathology, produced changes in CSF measures of biogenic amine system activity. Rosenblum et al (1994) administered the noradrenergic agonist yohimbine and the serotonergic agonist m-CPP to two groups of adult primates that had been reared under conditions of normal or disrupted social development.…”

Section: Early Adverse Experiences and Their Effects On Biological Comentioning

confidence: 99%

The evidence for a neurobiological model of childhood antisocial behavior.

Goozen¹,

Fairchild²,

Snoek³

et al. 2007

Psychological Bulletin

414

393

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Children with persistent antisocial and aggressive behavior are diagnosed as having disruptive behavior disorder. The authors review evidence that antisocial children, and especially those who persist with this behavior as they grow older, have a range of neurobiological characteristics. It is argued that serotonergic functioning and stress-regulating mechanisms are important in explaining individual differences in antisocial behavior. Moreover, low fear of punishment and physiological underactivity may predispose antisocial individuals to seek out stimulation or take risks and may help to explain poor conditioning and socialization. The authors propose a theoretical model highlighting the interplay between neurobiological deficits and cognitive and emotional functioning as mediators of the link between early adversity and antisocial behavior problems in childhood. Implications for intervention programs are discussed.

show abstract

A longitudinal study of the effect of different social rearing conditions on cerebrospinal fluid norepinephrine and biogenic amine metabolites in rhesus monkeys

Cited by 205 publications

References 0 publications

Seasonal Variation in CSF 5-HIAA Concentrations in Male Rhesus Macaques

Seasonal Variation in CSF 5-HIAA Concentrations in Male Rhesus Macaques

Effect of Tryptophan Treatment on Self-Biting and Central Nervous System Serotonin Metabolism in Rhesus Monkeys (Macaca mulatta)

The evidence for a neurobiological model of childhood antisocial behavior.

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