A Longitudinal Study of the Control of Renal and Uterine Hemodynamic Changes of Pregnancy

Ogueh, Onome; Clough, Angela; Hancock, Michelle Howell; Johnson, Mark R.

doi:10.3109/10641955.2010.484079

Cited by 34 publications

(24 citation statements)

References 41 publications

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“…The juxtaglomerular apparatus, which regulates afferent and efferent glomerular artery tone, may also be involved through resetting of the tubuloglomerular feedback system [57]. It seems likely that pregnancy-specific hormones, including relaxin or progesterone, play a role in these processes [58], [59].…”

Section: Discussionmentioning

confidence: 99%

Functional Vascular Changes of the Kidney during Pregnancy in Animals: A Systematic Review and Meta-Analysis

et al. 2014

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Renal vascular responses to pregnancy have frequently been studied, by investigating renal vascular resistance (RVR), renal flow, glomerular filtration rate (GFR), and renal artery responses to stimuli. Nonetheless, several questions remain: 1. Which vasodilator pathways are activated and to what extent do they affect RVR, renal flow and GFR across species, strains and gestational ages, 2. Are these changes dependent on renal artery adaptation, 3. At which cellular level does pregnancy affect the involved pathways? In an attempt to answer the questions raised, we performed a systematic review and meta-analysis on animal data. We included 37 studies (116 responses). At mid-gestation, RVR and GFR change to a similar degree across species and strains, accompanied by variable change in renal flow. At least in rats, changes depend on NO activation. At late gestation, changes in RVR, renal flow and GFR vary between species and strains. In rats, these changes are effectuated by sympathetic stimulation. Overall, renal artery responsiveness to stimuli is unaffected by pregnancy, except for Sprague Dawley rats in which pregnancy enhances renal artery vascular compliance and reduces renal artery myogenic reactivity. Our meta-analysis shows that: 1. Pregnancy changes RVR, renal flow and GFR dependent on NO-activation and sympathetic de-activation, but adjustments are different among species, strains and gestational ages; 2. These changes do not depend on adaptation of renal artery responsiveness; 3. It remains unknown at which cellular level pregnancy affects the pathways. Our meta-analysis suggests that renal changes during pregnancy in animals are qualitatively similar, even in comparison to humans, but quantitatively different.

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Section: Discussionmentioning

confidence: 99%

Functional Vascular Changes of the Kidney during Pregnancy in Animals: A Systematic Review and Meta-Analysis

et al. 2014

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“…Kidney length increases by approximately 1cm (3). Dilation of the ureters, renal pelvis and calyces occur bilaterally but to a greater degree on the right.…”

Section: The Renal System In Normal Pregnancymentioning

confidence: 97%

Disentangling the effects of climate, topography, soil and vegetation on stand-scale species richness in temperate forests

Zellweger

Braunisch

Morsdorf

et al. 2015

Forest Ecology and Management

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“…Increased uterine artery RI in Pgf À/À dams indicated an increase in downstream vascular impedance [43]. PGF is known to contribute to uterine artery vasodilation, and these effects are pronounced in pregnancy [14]; in this way, PGF contributes to uterine artery remodeling in response to pregnancy [44].…”

Section: Pgf Affects Gestational Cardiovascular Adaptationmentioning

confidence: 99%

Placental Growth Factor Influences Maternal Cardiovascular Adaptation to Pregnancy in Mice1

Aasa

Zavan

Luna

et al. 2015

Biology of Reproduction

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In healthy human pregnancies, placental growth factor (PGF) concentrations rise in maternal plasma during early gestation, peak over Weeks 26-30, then decline. Because PGF in nongravid subjects participates in protection against and recovery from cardiac pathologies, we asked if PGF contributes to pregnancy-induced maternal cardiovascular adaptations. Cardiovascular function and structure were evaluated in virgin, pregnant, and postpartum C56BL/6-Pgf(-) (/) (-) (Pgf(-) (/) (-)) and C57BL/6-Pgf(+/+) (B6) mice using plethysmography, ultrasound, quantitative PCR, and cardiac and renal histology. Pgf(-/-) females had higher systolic blood pressure in early and late pregnancy but an extended, abnormal midpregnancy interval of depressed systolic pressure. Pgf(-/-) cardiac output was lower than gestation day (gd)-matched B6 after midpregnancy. While Pgf(-) (/) (-) left ventricular mass was greater than B6, only B6 showed the expected gestational gain in left ventricular mass. Expression of vasoactive genes in the left ventricle differed at gd8 with elevated Nos expression in Pgf(-) (/) (-) but not at gd14. By gd16, Pgf(-) (/) (-) kidneys were hypertrophic and had glomerular pathology. This study documents for the first time that PGF is associated with the systemic maternal cardiovascular adaptations to pregnancy.

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A Longitudinal Study of the Control of Renal and Uterine Hemodynamic Changes of Pregnancy

Cited by 34 publications

References 41 publications

Functional Vascular Changes of the Kidney during Pregnancy in Animals: A Systematic Review and Meta-Analysis

Functional Vascular Changes of the Kidney during Pregnancy in Animals: A Systematic Review and Meta-Analysis

Disentangling the effects of climate, topography, soil and vegetation on stand-scale species richness in temperate forests

Placental Growth Factor Influences Maternal Cardiovascular Adaptation to Pregnancy in Mice1

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